Provisional Timetable
(Subject to change: The conference may finish slightly earlier or later than the advertised time)
Event type: Virtual/in-person hybrid
Presentation language: English
Venue: The Jarvis Doctorow Hall, St Edmund Hall, Queen’s Lane, Oxford, UK
Time zone: All times mentioned refer to British Standard/Summer Time (BST) – London/GMT+01:00.
Password and links: Registered conference delegates will be sent joining information and conference access links a few days before the conference.
World Time Converter: https://www.worldtimebuddy.com
NB: Due to the hybrid nature of the agenda and the wide geographical locations of our speakers, it may not have always been possible to group together related presentations.
Day 1: Monday 27th March 2023
1000: Registration and welcome coffee
1050: Welcome and housekeeping
Session I: Chair Professor Thomas Carell
1100: Professor Tom Brown (keynote)
Professor of Chemistry, Chemistry Department, University of Oxford, Oxford, UK
Charge neutral modifications to enhance the cell uptake and activity of exon-skipping oligonucleotides
1130: Dr Andrew Kellett
Associate Professor of Inorganic and Medicinal Chemistry, School of Chemical Sciences, Dublin City University, Dublin, Ireland
A Click Chemistry Approach to Developing Gene-Directed Metallodrugs
1200: Professor Afaf El-Sagheer
Senior Lecturer of Nucleic Acid Chemistry, Chemistry Department, University of Southampton, Southampton, UK
Simple chemical ligation for mRNA detection and quantification
1230: Dr Lucas Bethge
VP, Group Leader Chemistry, Silence Therapeutics GmbH, Berlin, Germany
Metabolic stabilization of GalNAc-conjugated siRNA: application of phosphorodithioates allow for a stereo defined mRNAi trigger
1250: Lunch, posters and networking
Session 2: Chair Dr Andrew Kellett
1350: Dr Nebojsa Janjic
Chief Science Officer, SomaLogic Inc, Boulder, CO, USA
From single-stranded nucleic acid sequences to intricate shapes: emerging insights from aptamer structures
1420: Dr Juewen Liu
Professor, Department of Chemistry, University of Waterloo, Waterloo, ON, Canada
Aptamer-enhanced ocular drug delivery and selection of new aptamers
1450: Dr Sérgio F Sousa
Group Leader, BioSIM, Dept Biomedicina, Faculdade de Medicina da Universidade do Porto, Portugal
Use of Biomolecular Simulations to Understand and Engineer Aptamer Recognition for Biomedical Applications
1510: Miss Teffanie Arputheraj
Research Associate (Aptamer Lead), Biogenes Technologies Sdn Bhd, Infrastructure University Kuala Lumpur (IUKL), Unipark Suria, Kajang, Selangor, Malaysia
Generation of in silico-based DNA aptamers targeting E6 and E7 oncoproteins of HPV using APTCAD technology
1530: Refreshments, posters and networking
Session 3: Chair Dr Nebojsa Janjic
1600: Dr Margaret Lange (V)
Assistant Professor, Department of Molecular Microbiology & Immunology, University of Missouri, Columbia, MO, USA
RNA Aptamers: modulators, potential therapeutics, and tools for better understanding molecular interactions
1630: Dr Lorenzo Di Michele (V)
Assistant Professor in Biotechnology, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
Patterning DNA-based artificial cells with reaction-diffusion
1700: Dr Mark Behlke (V)
Chief Scientific Officer, Integrated DNA Technologies, Inc, Commercial Park, Coralville, Iowa, USA
Methods to improve CRISPR HDR efficiency
1730: Dr Keith Gagnon (V)
Associate Professor, Biochemistry & Molecular Biology, School of Medicine, Southern Illinois University, Carbondale, IL, USA
Understanding the 2’-hydroxyl barrier to CRISPR RNA ribose modification
1800: Professor Larry Gold (keynote)
University of Colorado and SomaLogic Inc, Boulder, CO, USA
TBA
1830: Close of Day 1
1900: Networking dinner (by prior booking or invitation)
Day 2: Tuesday 28th March 2023
Session 4: Chair Dr Sylvain Ladame
0830: Dr Marcel Hollenstein (V)
Group Leader, Laboratory for Bioorganic Chemistry of Nucleic Acids, Department of Chemistry and Structural Biology, Institut Pasteur, Paris, France
TBA
0900: Professor Dr Thomas Carell
Chair for Organic Chemistry, Department for Chemistry, Institute for Chemical Epigenetics (ICE-M), LMU München, Munich, Germany
The prebiotic origin of RNA nucleosides and translation
0930: Professor Simon Richardson (co-presenter Dr Vineeta Tripathi)
Reader of Drug Delivery and Membrane Trafficking, Exogenix laboratory, Faculty of Engineering and Science, Greenwich University, Kent, UK & Vitraka Therapeutics Ltd, London, UK
Preliminary body distribution data characterising a recombinant siRNA delivery system “EndoPore”
1000: Dr Edward Curtis
Group Leader, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Czech Republic
Exploring sequence space using secondary structure libraries and single-step selections
1030: Refreshments, posters and networking
Session 5: Chair Dr Simon Richardson
1050: Professor Michal Hocek
Professor and Group Head, Bioorganic & Medicinal Chemistry of Nucleic Acids, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Czech Republic
Functionalized and hypermodified nucleic acids for targeting proteins
1110: Dr Marco Di Antonio
David Phillips Research Fellow, Faculty of Natural Sciences, Department of Chemistry, Imperial College London, London, UK
The C9Orf72 hexanucleotide repeat expansion transcript forms insoluble aggregates facilitated by multimolecular G-quadruplex structures
1140: Dr Sylvain Ladame
Reader in Biosensor Development & Senior Tutor for Research, Department of Bioengineering, Imperial College London, London, UK
Engineering of a screening test for early prediction of preterm birth based on the detection of miRNAs from maternal blood
1210: Dr Dana Alsulaiman
Assistant Professor, Material Science and Engineering, Physical Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia
An enzyme-free electrochemical platform for microRNA detection based on peptide nucleic acid-functionalized nanomaterials
1240: Discussion and close
