The conference promises to provide a relaxed, friendly and intellectually-stimulating discussion forum, and will feature:
o Emerging and cutting-edge topics addressing most aspects of basic and applied research on zoonotic and human influenza viruses
o Keynote addresses by world leaders in influenza research
o Distinguished faculty comprising senior and junior scientists
o Global participation by scientists from academia, industry and government organisation
o Excellent networking opportunities
The Conference will cover the following general areas of influenza research:-
o Molecular and structural virology
o Immunology and vaccination
o Host-pathogen interaction – virulence and pathogenecity
o Epidemiology and evolution
o National and international surveillance and contingency strategies
o Advances in viral detection and identification technologies
Respiratory Viruses 2015 – Serology and Sero-Surveillance
Co-located Pre-conference Symposium
7th September 2014
St Hilda’s College, Oxford
Speaker and agenda
Session 1: Public health and virus transmission
14.30: Dr Richard Pebody
Acting head, Respiratory Diseases Department, Centre of Infectious Disease Surveillance and Control, Public Health England, UK
Influenza surveillance and the challenge of evaluating the national influenza vaccine programme
15.00: Professor Jonathan Van-Tam (Keynote Speaker)
Professor of Health Protection, University of Nottingham, UK
Human challenge transmission experiments – failure of a quarantine based model
15.40: Refreshment break and networking
Session 2: Structural and molecular biology
16.10: Professor Wendy Barclay
Professor of Virology, Imperial College London, UK
Species difference in host protein ANP32A underlies influenza A polymerase host restriction host protein
16.40: Professor Ervin Fodor
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Molecular mechanisms of influenza virus replication
17.10: Dr Xiaoli Xiong
The Francis Crick Institute, Mill Hill Laboratory, London, UK
Structures of complexes formed by H5 influenza haemagglutinin and a potent human monoclonal antibody
17.40: Dr Pawel Zmora
Infection Biology Unit, German Primate Center, Germany
The stem region of type II transmembrane serine proteases is a determinant of influenza virus activation
18.00: Miss Claire Scott
St James’ University Hospital, University of Leeds, UK
Structure-guided design of novel inhibitors targeting the drug resistant M2 proton channel from pandemic swine influenza
18.20: close
Day 2: 9th September 2015, Jacqueline Du Pré Music Building (JdP)
Session 3: Vaccines, immunology, antivirals
09.00: Professor Sarah Gilbert
Professor of Vaccinology, University of Oxford, UK
Further clinical assessment of vaccines designed to boost T cell responses to conserved Influenza A antigens
09.30: Professor James Stewart
University of Liverpool, UK
The putative antimicrobial peptide BPIFA1/SPLUNC1 restricts Influenza A virus infection in the host
10.00: Professor Bernadette M Dutia
The Roslin Institute & Royal (Dick) School of Veterinary Studies, Edinburgh, UK
Acute influenza A pathogenesis is ameliorated in a murine model of latent gamma herpesvirus infection
10.30: Refreshment break and networking
11.00: Professor John Oxford
Blizard Institute, Queen Mary College, London
Serological techniques and the formulation and tests of a Universal Influenza Vaccine
11.30: Professor Alain Townsend
Weatherall Institute, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
S-FLU – A pseudotyped influenza virus vaccine that provides broad “heterotypic” protection against group 1 and 2 influenza A viruses in mice and ferrets
12.00: Dr Anthony Marriott
Public Health England, UK
Animal models for influenza
12.30: Dr Elma Tchilian
The Pirbright Institute, Woking, Surrey, UK
Distinct immune responses and viral shedding patterns in pigs following aerosol, intranasal and in contact infection with pandemic H1N1 swine influenza virus
12.50: Lunch and networking
Session 4: Zoonotic
14.10: Dr Sylvia S Reemers
MSD Animal Health, Boxmeer, The Netherlands
A potential broadly protective avian influenza vector vaccine
14.40: Professor Kristien Van Reeth
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan, Merelbeke, Belgium
Heterologous prime-boost vaccination with H3N2 influenza viruses of swine, or “going broad” with killed influenza vaccine
15.10: Professor Ian Brown (Keynote)
Director of EU/FAO/OIE Reference Laboratory for Avian & Swine Influenza, Animal and Plant Health Agency-Weybridge, United Kingdom; Visiting Professor in Avian Virology, University of Nottingham, UK
New and re-emerging challenges for the detection and control of zoonotic animal influenza
15.50: Refreshment break and networking
16.30: Professor Dr Timm Harder
Institute of Diagnostic Virology, Friedrich Loeffler Institute, Greifswald-Riems, Germany
Sessile or mobile: Why do certain lineages of HPAIV H5 show geographic mobility and others not?
17.00: Dr Sharon Brookes
Animal and Plant Health Agency, UK
An update on pandemic influenza H1N1 (A/H1N1pdm09) in pigs 2009-2014
17.30: Mrs Caroline Warren
Animal and Plant Health Agency (APHA) Virology Department, New Haw, Surrey, UK
Modelling the survival of avian influenza viruses in commercial poultry scenarios
17.50: Close
19.00: Networking Dinner (by prior booking or invitation only)
Day 3: 10th September 2015, Jacqueline Du Pré Music Building (JdP)
Session 5: Detection and assay development
Chairs: Dr Nigel Temperton and Dr Simon Scott
09.00: Professor Emanuele Montomoli
University of Siena and CSO VisMederi srl, Italy
Immunological assays for Influenza vaccines evaluation
09.30: Dr Simon Scott
Viral Pseudotype Unit, School of Pharmacy, University of Kent, Central Avenue, Chatham Maritime, UK
Development of a pseudotype virus-based neutralization assay for seal influenza virus serological screening
09.50: Dr Nigel Temperton
School of Pharmacy, University of Kent, UK
The application of pseudotypes to Influenza pandemic preparedness
10.10: Dr Scott M Reid
Animal and Plant Health Agency (APHA-Weybridge), UK
Development and validation of molecular tools for sub-typing swine influenza viruses
10.30: Miss Sahar Mahmood
Animal and Plant Health Agency (APHA-Weybridge), UK
The importance of maintaining an accurate and sensitive Real Time PCR testing capability to detect current avian influenza virus threats of diverse origins
10.50: Dr Genyan (Patrick) Yang
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
Subtyping Influenza A Virus by cDNA Hybridization and Sequence-independent Amplification
11.10: Mr Jose C Mancera-Gracia
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
A role for swine in the adaptation of H9N2 avian influenza viruses to humans?: Lessons from serial passages and transmission studies in pigs
11.30: Lunch and close
Posters
Preparation and Immunogenicity Evaluation of Influenza A/H7N9 Virus-like Particle
Chu-Yang Chien1, Ming-Tsan Liu2, Sui-Yuan Chang3, Shih-Chung Chang4, Rong-Huay Juang4, Hui-Wen Chen1
1Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
2National Influenza Center, Centers for Disease Control, Taipei, Taiwan
3Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan
4Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
Airborne spread of influenza viruses: towards quantifying emissions of virus-aerosols from infected pig and poultry farms
Jose L Gonzales1, Andre J A Aarnink2, Thomas Hagenaars1
1Department of Epidemiology, Crisis organization and Diagnostics, Central Veterinary Institute (CVI) part of Wageningen UR, P.O. Box 65, 8200 AB Lelystad, the Netherlands.
2Wageningen UR Livestock Research, Wageningen, the Netherlands
Delayed immune response in interferon regulatory factor 3 (Irf3) knock-out mice after influenza A infection
Hang TT Hoang1,2, Bastian Hatesuer1,2and Klaus Schughart1,2,3
1Helmholtz Centre for Infection Research, Department of Infection Genetics, Inhoffenstraße 7, 38124 Braunschweig, Germany
2University of Veterinary Medicine Hannover, Hannover, Germany
3University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
To Study the Effects of Autophage on H5N1 Infection of Immature Dendritic Cells
Chien-Chih Lee1, Ching-Yu Huang1, Jason C. Huang1,2
1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University
2AIDS Prevention and Research Centre, National Yang-Ming University
Modulation of antigen processing of conserved epitopes in the hemagglutinin as a rational design of a cross-protective influenza live vaccine
Young Jae Lee1, Ji Eun Yu1, Paul Kim1, Yo Han Jang1, and Baik Lin Seong1,2
1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
2Vaccine Translational Research Center, Yonsei University, Seoul, South Korea
CXCR3 ligands derived from myeloid derived suppressor cells are responsible for the recruitment of effector T cells during influenza A virus infection
Sue-Jane Lin1,2,3, Chi-Hsiang Huang1,4, Wayne CW Huang1,4 and Ching-Hwa Tsai5
1Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
2Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
3Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
4School of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
5Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Production and protective efficacy of a subunit yeast-expressed H5 vaccine against challenge with H5N1 highly pathogenic avian influenza virus
Agnieszka Maciola1, M Olszewska2, M Pietrzak1, K Zdanowski1, A Protas1, K Grzelak 1, K Śmietanka2, Z Minta2, W Zagorski-Ostoja1, E Kopera1
1Institute of Biochemistry and Biophysics, Polish Academy of Science, Pawińskiego 5A, 02-106 Warsaw, Poland
2National Veterinary Research Institute, Department of Poultry Diseases, Al. Partyzantow 57, 24-100 Pulawy, Poland
Antigenic and genetic differences relate to vaccine efficacy of avian influenza subunit but not whole inactivated vaccines
Sylvia S. Reemers1, Cornelis A. de Haan2, Jos Dortmans2, Saskia van de Zande1, Peter J. Rottier2, Ian Tarpey1, Ben Peeters3
1MSD Animal Health, Boxmeer, The Netherlands
2Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
3Central Veterinary Institute, Wageningen University and Research Centre, Lelystad, The Netherlands
Pseudotype based neutralisation assays for influenza: a systematic analysis
George W Carnell1, Francesca Ferrara1, Keith Grehan1, Craig P Thompson 1,2,3 and Nigel J Temperton 1
1Viral Pseudotype Unit, Medway School of Pharmacy, The Universities of Greenwich and Kent, Kent, UK
2Department of Zoology, University of Oxford, Oxford, UK
3The Jenner Institute Laboratories, University of Oxford, Oxford, UK
The application of pseudotypes to influenza pandemic preparedness
Francesca Ferrara, Eleonora Molesti and Nigel J Temperton
Viral Pseudotype Unit, Medway School of Pharmacy, The Universities of Greenwich and Kent, Kent, UK
The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection
Ching-Hwa Tsai1 and Sue-Jane Lin2,3,4
1Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
2Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
3Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
4Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Development of dual detection system of real-time PCR for H7 subtype HA genes of avian influenza viruses
Yuta Kuramochi, Yuhei Furuyama and Kenji Tsukamoto
Laboratory of Animal Health 2, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, JAPAN
Screening Small Molecules for Inhibition of Ebola Virus Cell Entry
Julie Xiao1, Pramila Rijal1, Beibei Wang1,2, Antony Galione3, Alain R Townsend1
1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, UK
2Beijing Ditan Hospital, Beijing
3Department of Pharmacology, University of Oxford, UK
