Speakers & agenda

Oxford Symposia - 5th Annual


Antisense & Therapeutic Nucleic Acids

1-2 April 2019, St Edmund Hall, Oxford, UK

Twitter: @LPMHealthcare, #OligoOx19

Provisional Agenda

(subject to change)

Monday 01 April 2019 | St Edmund Hall | Oxford, UK

1030-1110: Registration, welcome coffee and networking

1110: Welcome and housekeeping

Session  1:  Chemistry  and  catalysis
Chair  Dr  Simon  Richardson

1115: Professor Tom Brown and Dr Ysobel Baker, University of Oxford, Oxford, UK
Studies on Oligonucleotides with Chemically Modified backbones

1215:  Dr Alexander Taylor, MRC Laboratory of Molecular Biology, Cambridge, UK
Towards versatile RNA endonuclease XNAzymes with catalytic activity in physiological conditions

1245:  Dr Marcel Hollenstein, Institut Pasteur,  Paris, France
Modified nucleoside triphosphates: versatile tools in chemical biology

1315:  Lunch break, posters and exhibition

1400:  Mr Simon Chi-Chin Shiu, The University of Hong Kong, Hong Kong, PR China
Signal Enhancement by Aptamer-Enabled DNA Polyhedra and Lattices

1420: Miss Bahareh Amirloo, University of Manchester, Manchester, UK
Towards catalytic turnover: bulge-loop inducing peptidyl-oligonucleotide conjugates for irreversible cleavage of RNA

Session  2:  IP & Delivery
Chair  Dr  Tom  Brown

1440: Dr Alison Gallafent, Harrison Goddard Foote (HGF), York, UK
SiRNA and Patents

1500: Dr Simon Richardson, University of Greenwich, London, UK
Exosomes: A Potential siRNA, Antisense And Gene Editing Delivery Platform

1530: Networking Break, posters and exhibition

1600: Professor Rula Zain, Karolinska University Hospital, Sweden
Title TBA

1630: Dr David Evans, Sirnaomics, USA
SiRNA delivery to the liver for therapeutics to treat Fibrosis and Cancer

1700: Dr Ana Paula Pêgo, INEB & i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
Nucleic acid delivery to the nervous system: breaking barriers exploring nanobiomaterials to promote neuroprotection and neuroregeneration

1730: Dr Pedro MD Moreno, INEB & i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
In situ delivery of LNA gapmers for gene silencing in spinal cord injury

1750: Dr Patrick Baril, Centre de Biophysique Moléculaire, CNRS UPR4301, Université d’Orléans, Orléans, France
Locoregional delivery and monitoring of miRNA activity in orthotopic model of glioblastoma using a genetic switch luciferase expression system, RILES

1810: Close

1900: Networking dinner (by prior booking or invitation only)

Tuesday 02 April 2019 | St Edmund Hall | Oxford, UK

Session 3: Delivery, and Therapeutic and diagnostic applications
Chair Professor Mike Cheetham

0900: Dr Andrea Masotti, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes and bidimensional buckypapers

0930: Dr Sylvain Ladame, Imperial College London, London, UK
Early prediction and monitoring of preterm birth: Toward a new paper-based blood test based on detection of highly specific microRNA biomarkers

1000: Dr Haiyan Zhou, University College London, London, UK
Antisense oligonucleotides therapy for COL6-related congenital muscular dystrophy

1030: Networking Break, posters and exhibition

Session 4: Therapeutic and diagnostic applications (contd)
Dr Sylvain Ladame

1100: Professor Peter Zammit, King’s College London, London, UK
Use of antisense oligonucleotide-mediated exon-skipping to remove an exon containing a pathogenic missense mutation: a potential therapy for certain laminopathies?

1130: Dr Mike Cheetham, UCL Institute of Ophthalmology, London, UK
Using iPSC organoid models to develop antisense therapies for inherited retinal disease

1200: Ms Sameen Yousaf, University of Manchester, Manchester, UK
Self-assembling peptide hydrogels: development of 3D nano-biosensor for sequence specific detection of nucleic acids

1220: Close