Speakers & agenda

Oxford Symposia - 2nd Annual


Antisense & Therapeutic Nucleic Acids

06 April 2016, St Hilda's College, Oxford, UK

Twitter: @LPMHealthcare, #OligoOxford

Speakers & agenda

(subject to change)

08.30:    Registration welcome coffee, networking, exhibition

09.20:    Welcome and housekeeping

Session 1: Chair Professor Andrew Miller

09.30:    Dr Mark Edbrooke, Oncology iMED, AstraZeneca, Cambridge, UK

Therapeutic antisense oligonucleotides – significant progress towards a viable drug platform for tackling intractable targets in oncology

10.00:    Professor Tom Brown, University of Oxford, UK

Chemical ligation of DNA, biocompatibility and applications of artificial chemical linkages

10.30:    Dr Marcel Hollenstein, Pasteur Institute, Paris, France

Modified nucleoside triphosphates: synthetic tools for the development of catalytic DNAs

11.00:    Refreshment break

11.30:    Professor Francesco Muntoni, University College London, London, UK

Chronic low-dose morpholino antisense oligomer to generate SMA mice with intermediate phenotype

12.00:    Professor Peter Zammit, King’s College London, London, UK

Ameliorating pathogenesis by removing an exon containing a missense mutation: a potential exon-skipping therapy for laminopathies

12.30:    Dr Igor Vorechovsky, University of Southampton, Southampton, UK

Antisense oligonucleotides targeting intronic sequences: NMD switch exons in focus

1300:     Lunch

Session 2: Chair Professor Tom Brown

13.50:    Dr David BlakeyCSO, MiNA therapeutics, London, UK

Small activating RNA therapeutics for transcriptional gene activation

14.20:    Dr Viorel Simion, CNRS, Université d’Orléans and Inserm, France

LentiRILES : a novel cell-based bioluminescence platform for screening of miRNA formulations for miRNA-based cancer therapy

14.50:    Dr Sylvain Ladame, Imperial College London, London, UK

Engineered Peptide Nucleic Acids (PNAs) and Cancer: therapeutic and diagnostic applications

15.20:    Refreshment break

15.50:    Dr Philipp HolligerMRC Laboratory of Molecular Biology, Cambridge, UK

Synthetic genetics

16.20:    Professor Andrew Miller, King’s College London, London, UK

The opportunities for medicine presented by the chemistry and biology of dinucleoside polyphosphates

16.50:    Dr Simon Richardson, Biopharmaceutical Sciences, University of Greenwich, UK

Attenuated Anthrax Toxin: application to cytosolic antisense and siRNA delivery