Venoms 2013


  • Venoms 2013 Summary

    Making Sense of Venoms in Health and Disease

    24-26 September 2013, St Hilda's College, Oxford, UK

    Venoms offer a substantial pool of bioactive compounds with therapeutic and pharmacological potential. The 2nd Oxford World Symposium on Venoms, Venoms 2013, is aimed at providing an international platform to scientists from academia, industry and clinical settings to discuss and explore this huge reservoir of potential lead compounds for drug development.

    Venoms 2013 covered a variety of topics in toxinology, including:

    • Isolation and characterisation of bioactive lead compounds
    • Anti-venom vaccines, therapeutics and envenomation treatment strategies
    • Envenomation as a neglected tropical disease
    Distinguished keynote speakers

    Prof Dr Dietrich Mebs

    Prof Christopher Shaw

    Prof Cesare Montecucco

    Prof Dr Juan Calvete

    Professor Mebs received a Life-time Achievement Award at Venoms 2013 for his exceptional contributions to the field of toxinology.

  • Distinguished Speakers

    Professor Dr Dietrich Mebs - Keynote Address
    University of Frankfurt, Germany
    Title: Surviving toxicity: resistance, adaptations, chemical camouflage

    Professor Jan Tytgat
    Toxicology & Pharmacology, University of Leuven (KU Leuven), 3000 Leuven, Belgium
    Title: Sea anemone secretions continue to surprise us with novel bioactive peptides

    Professor Songping Liang
    College of Life Sciences , Hunan Normal University, Changsha, 410081, Hunan, China
    Title: Antimicrobial Potential of Lycosin-I, a Cationic and Amphiphilic Peptide from the Venom of the Spider Lycosa Singorensis

    Dr Mohamed A Abdel-Rahman
    Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt, and Biomedical Research Centre, Biosciences Division, Sheffield Hallam University, Sheffield, UK
    Title: Characterization of new antimicrobial peptides from the Egyptian scorpionScorpio maurus palmatus

    Professor Dr Cesare Montecucco - Keynote Address
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    Title:
    Neuromuscular junction degeneration and regeneration following snake presynaptic PLA2 neurotoxins poisoning

    Professor Alan Harvey
    University of Strathclyde, Glasgow, UK and Dublin City University, Dublin, Ireland
    Title: What can toxins provide for drug discovery?

    Professor Dr Igor Križaj
    Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia
    Title: Venomics of the Vipera a. ammodytes snake to discover innovative drugs and diagnostic tools

    Dr Eric Lingueglia
    Institute of Molecular and Cellular Pharmacology, CNRS/University of Nice-Sophia Antipolis UMR7275, Sophia Antipolis, Valbonne, France
    Title: Venom Peptides to Understand the Role of Acid-Sensing Ion Channels in the Pain Pathway

    Dr Nicholas Casewell
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, UK and School of Biological Sciences, Bangor University, Environment Centre Wales, Bangor LL57 2UW, UK
    Title: The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system

    Dr Walter Luís Garrido Cavalcante
    Department of Physics and Biophysics, Institute of Biosciences, São Paulo State University, Botucatu/SP, Brazil
    Title: Inhibition of neurotoxic effect of phospholipase A 2 from crotoxin complex by suramin in mouse neuromuscular preparation

    Professor Dr Juan Calvete - Keynote Address
    Laboratorio de Venómica y Proteinómica Estructural, Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain
    Title:
    Genus-wide venom proteomics across New World pitviper genera

    Professor Michael Eddleston
    National Poisons Information Service - Edinburgh, Royal Infirmary of Edinburgh and University of Edinburgh, UK
    Title: Plant poisoning as a neglected tropical disease

    Professor David Warrell
    Nuffield Department of Clinical Medicine, University of Oxford, UK

    Professor Julian White
    Toxinology Department, Women’s & Children’s Hospital, North Adelaide, Australia
    Title: The Australian Clinical Toxinology Experience; Are We On The Right Track?

    Professor Dr Thomas Junghanss and Dr Mauro Bodio
    Section Clinical Tropical Medicine, University Hospital, Heidelberg, Germany; and Swiss Tropical & Public Health Institute, Basle, Switzerland
    Title: VAPAGuide – The free access Emergency Guide to Venomous and Poisonous Animals

    Dr Robert Harrison
    Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, UK
    Title: Immunisation with toxin group-specific epitope strings to generate IgGs against each medically-important group of toxins in venoms of the African saw-scaled viper species

    Professor Dr Philippe Billiald
    University Paris-Sud & MNHN-CNRS UMR7245, Paris, France
    Title: Engineering of Neutralizing Recombinant Antibody Fragments Directed Against Venom Toxins

    Professor Christopher Shaw - Keynote Address
    School of Pharmacy, Queen’s University Belfast, Northern Ireland, UK
    Title:
    Too much of a good thing: therapeutic peptide mining of the amphibian skin defensome/venome

    Dr Ulrich Kuch
    Medical Biodiversity and Parasitology Biodiversity and Climate Research Centre (BiK-F) Senckenberganlage, Frankfurt, Germany

    Dr Edward Rowan
    University of Strathclyde, Glasgow, UK

    Dr John Archer
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK
    Title: Slaying the Chimera in Venom Gland Transcriptomics

    Dr Wolfgang Wüster
    School of Biological Sciences, Bangor University, Environment Centre Wales, Bangor LL57 2UW, UK
    Title: Why is snake venom so variable?

  • Posters Presented at Venoms 2013

    (Presenters in Bold)

    Toxicity and morphological changes induced by Naja pallida venom on human prostate cancer cell lines and human neuroblastoma cell line

    Basher M Abdalsaed, Alan L Harvey and Edward G Rowan

    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom

    Pancreatic beta cell compensation for insulin resistance induced by experimental scorpion snvenomation

    Aouatef AIT-LOUNIS, Fatima LARABA-DJEBARI

    USTHB, Faculty of Biological Sciences; Laboratory of Cellular and Molecular Biology, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria

    Slaying the Chimera in Venom Gland Transcriptomics

    Archer J 1, Whiteley G 1, Casewell N 1,2, Rowley P, Harrison R 1 and Wagstaff S 1

    1 Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK and 2 School of Biological Sciences, Bangor University, Deiiol Rd, Bangor, UK

    Bothropoidin, a new metalloproteinase from Bothropoides pauloensis snake venom: effect on endothelial cell adhesion and viability

    Veridiana de Melo Rodrigues Ávila 1,5; Mário Sérgio Rocha Gomes 4,; Daiana Silva Lopes 1; Dayane Lorena Naves de Sousa 1; Denise de Oliveira Guimarães 1; Ricardo Ávila Oliveira 2; Fábio de Oliveira 3,5, Kelly A. G. Yoneyama Tudini 1; Renata Santos Rodrigues 1,5

    1Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia,UFU, Brazil; 2Departamento de Cirurgia, UFU, Brazil; 3Instituto de Ciências Biomédicas UFU, Brazil; 4Universidade Estadual do Sudoeste da Bahia, UESB, Brazil; 5Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (N-Biofar), Belo Horizonte-MG, Brazil

    The use of recombinant colorimetric immunoconjugates for the detection an titration of venoms of Loxosceles intermedia, Loxosceles laeta andLoxosceles gaucho spiders

    Becker-Finco A 1, Ramada J 1, Silva S K 1, De Moura J 1, Billiald P 2, Alvarenga L M 1, 2

    1 Departamento de Patologia Básica, UFPR, Curitiba - PR, Brazil; 2 Muséum National d’Histoire Naturelle, UMR CNRS 7245, Paris, France

    Pathology in a Murine Model of Snake Envenoming

    Fiona M.S. Bolton1, David A Warrell2 and Robert A. Harrison1

    1 Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK and 2 The University of Oxford, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK

    Pathological changes induced in capillaries by CcH1, a hemorrhagic metalloproteinase isolated from Cerastes cerastes venom

    Hinda BOUKHALFA-ABIB, Fatima LARABA-DJEBARI

    USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32, El-Alia Bab Ezzouar, Algiers, Algeria

    Long-term immunoprotective effect against scorpion envenomation induced by gamma irradiated toxoid

    Lila Boussag-Abib, Rebbouh Farah, Laraba-Djebari Fatima

    USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 EL-ALIA, BAB EZZOUAR, Algiers, Algeria

    An integrated strategy to prevent poisonous animal accidents: from the university to the community

    Walter Luis Garrido Cavalcante 2 , Carlos Alberto da Silva Ribeiro 1, Fábio Florença Cardoso 2, Lauane Gonçalves de Araújo 1, André Sartori 1, Tatiana Roveran 1, Isabela França 1, Márcia Gallacci 1

    1 Department of Pharmacology and 2Department of Physics and Biophysics, Institute of Biosciences, University of São Paulo State, Botucatu, São Paulo, Brazil.

    Use of two fibrinogenases (CC3-SPase and CCSV-MPase) isolated fromCerastes cerastes venom as therapeutic tools in hemostasis

    Fatah CHERIFI, Fatima LARABA-DJEBARI

    USTHB, Faculty of Biological Sciences; Laboratory of Cellular and Molecular Biology, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria

    THE ANTIVENOMIC CHARACTERIZATION OF ANTIBODIES AGAINST ELAPID THREE FINGER TOXIN AND PLA2 MOLECULES FROM MICRURUS VENOMS

    Correa-Netto, C1,2., Garcia, E1., Machado, L. G2., , Araújo, R. T1,2., Lima L.M.T.R3., Perez-Payá. E4,5., Calvete, J. J4., Foguel, D & Zingali, R. B2

    1-Instituto Vital Brazil; 2-IBQM-UFRJ; 3-Faculdade de Farmácia-UFRJ; 4-Instituto de Biomedicina de Valencia, CSIC, Espanha; 5-CIPF, Valencia, Espanha.

    Biophysical analysis of Smp24, an antimicrobial peptide from the venom of the Egyptian scorpion Scorpio maurus palmatus

    Patrick L. Harrison 1, Mohamed A. Abdel-Rahman 1,2 , L. Barber 1, G. Heath 3, S. Evans 3, , Peter N. Strong 1, Keith Miller 1

    1 Biomedical Research Centre, Biosciences Division, Sheffield Hallam University, Sheffield, UK. 2 Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt. 3School of Physics & Astronomy, Leeds University , WY, UK

    Isolation and functional characterization of Bmoo-Agg, a new platelet-aggregation-Inhibiting factor from Bothrops moojeni snake venom

    Fábio de Oliveira 1, 3, Bruna B. de Sousa 1,3, Daiana Silva Lopes 2; Renata S. Rodrigues 2,3; Veridiana M. Rodrigues 1,3

    1 Instituto de Ciências Biomédicas UFU, Brazil; 2Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia,UFU, Brazil; 3 Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (N-Biofar), Belo Horizonte-MG, Brazil

    The National Serum Depot in the Netherlands: analysis of five years of exotic snake bites

    Dijkman MA, Van der Zwan CW, Vries de I

    National Poisons Information Center, University Medical Center, Utrecht, the Netherlands, and National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

    Parawixia bistriata: An invaluable source of neuroactive compounds

    José Luiz Liberato 1,2, Lívea Dornela Godoy 1,2 and Wagner Ferreira dos Santos 1,2

    1 Neurobiology and Venoms Laboratory, Biology department, College of Philosophy, Sciences and Literature, University of São Paulo, Ribeirão Preto, SP, Brazil; 2 Instituto de Neurociências (INEC), Ribeirão Preto, SP, Brazil

    Muscle phospholipid hydrolysis by Asp49 and Lys49 phospholipase A 2 myotoxins from Bothrops asper: distinct mechanisms of action

    Julian Fernandez 1 , Paola Caccin 1, Grielof Koster 2, Bruno Lomonte 3, Jose Maria Gutierrez 3, Anthony D. Postle 2* and Cesare Montecucco 1

    1 Dipartimento di Scienze Biomediche Sperimentali, Università degli Studi di Padova, Italia; 2 School of Medicine, University of Southampton, Southampton, United Kingdom; 3 Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica

    The effects of Bbil-TX (Asp49 PLA 2) from Bothriopsis bilineata smargadina(forest viper) venom on the mouse peripheral nervous system

    Rafael Stuani Floriano 1 , Victor Corasolla Carregari 2, Sergio Marangoni 2, Léa Rodrigues-Simioni 1 and Edward G. Rowan 3

    1 Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 13083-887, Campinas, SP, Brazil; 2 Department of Biochemistry, Institute of Biology, State University of Campinas (UNICAMP), 13083-862, Campinas, SP, Brazil; 3 Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE, Glasgow, UK

    Remote Envenomation Consultation Services (RECS) For Healthcare Providers in Malaysia

    Ahmad Khaldun Ismail 1, Anisah Adnan 2, Azhana Hassan 3, Zainal Abidin Mohamed Ismail 4, Razak Daud 5

    1 Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia; 2 Emergency & Trauma Department, Melaka Hospital, Jalan Mufti Haji Khalil, 75400 Melaka, Malaysia; 3 Emergency & Trauma Department , Tuanku Ja’afar Hospital, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia; 4 Emergency & Trauma Department, Tengku Ampuan Afzan Hospital, Jalan Tanah Putih, 25100 Kuantan, Pahang, Malaysia; 5 Emergency & Trauma Department, Raja Perempuan Zainab II Hospital, Jalan Hospital, 15000 Kota Bahru, Kelantan, Malaysia

    Anti-cancer properties of snake venoms

    Sajjad Ali Khan, Dr Valerie Fero, Dr. Edward G. Rowan

    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK

    Immunological cross-reactivity of principal toxins of Naja sumatrana venom by a Thai polyvalent antivenom (Neuro Polyvalent Snake Antivenom)

    Poh Kuan Leong, Si Mui Sim, Shin Yee Fung and Nget Hong Tan

    Department of Pharmacology and Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Antiproliferative effect and ultrastructure alterations of BnSP-7, a catalytically inactive phospholipase A 2 from Bothrops pauloensis snake venom, on Leishmania (Leishmania) amazonensis

    Daiana Silva Lopes 1; Débora C. O. Nunes 1; Márcia M. N. R. Figueira 1; Dayane L. Naves de Souza 1; Eloísa A. V. Ferro 2; Maria A. Souza 3; Renata S. Rodrigues 1,4; Veridiana M. Rodrigues 1,4; Kelly A. G. Yoneyama 1

    1 Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia; 2Departamento de Morfologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia; 3Departamento de Patologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia; 4Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica (N-Biofar), Brazil

    Regeneration of skeletal muscle after Cerastes cerastes envenomation: its enhancement with heparin

    H Oussedik-Oumehdi, F Z Nourreddine and F Laraba-Djebari

    USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32, El-Alia, Bab Ezzouar,16111, Algiers, Algeria

    Inhibition of Toxic Effects of Snake Venom Metalloproteinases by the Recombinant Pro-Domain of Jararhagin

    José A. Portes-Junior 1, Michelle T.Almeida 1, Juliana L. Bernardoni 1, Leijiane F. Sousa 1, Robson L. Melo 1, Carolina A. Nicolau 2, Richard H. Valente 2, Ana M. Moura-da-Silva 1

    1 Laboratório de Imunopatologia, Instituto Butantan, São Paulo, 2Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

    Expression and characterization of rBP-SP, a serine protease from Bothrops pauloensis and its interference on hemostasis

    Renata Santos Rodrigues 1,8 ; Johara Boldrini-França 2; Ludier Kesser Santos-Silva 3; Mário Sérgio R. Gomes 4,8; Dayane L. Naves de Souza 1,8; Lino Fernando G. de Lima 1,8; Flávio Henrique-Silva 5; Ricardo Ávila Oliveira 6; Fábio de Oliveira 7; Kelly Aparecida Geraldo Yoneyama 1; Veridiana de Melo Rodrigues 1,8; Eliane Candiani Arantes 2

    1 Instituto de Genética e Bioquímica,Universidade Federal de Uberlândia,Brazil; 2Faculdade de Ciências Farmacêuticas de Ribeirão Preto,Universidade de São Paulo, Brazil; 3Instituto de Ciências Exatas e da Terra,Universidade Federal do Mato Grosso, Brazil; 4Departamento de Química e Exatas,Universidade Estadual do Sudoeste da Bahia,Brazil; 5Departamento de Genética e Evolução,Universidade Federal de São Carlos,Brazil; 6 Departamento de Cirurgia, UFU, Brazil; 7 Instituto de Ciências Biomédicas UFU, Brazil; 8 Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica, Brazil

    Comparative pharmacological studies of Bothrops jararaca and Bothrops fonsecai snake venoms

    Rita de Cássia O. Collaço 1, Igor Rapp F. da Silva 1, Mariana L. Tamascia 1, José Carlos Cogo 2, Stephen Hyslop 1, Priscila Randazzo-Moura 3, LéaRodrigues-Simioni 1

    1 Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP. 2 Serpentário do Centro de Estudos da Natureza. Universidade do Vale do Paraíba (UNIVAP), São José dos Campos, SP. 3Laboratório de Farmacologia, Faculdade de Ciências Médicas e da Saúde, Pontifícia Universidade Católica de São Paulo (PUC-SP), Sorocaba, SP, Brazil

    Multi-organ dysfunction induced by Aah II, a neurotoxin isolated fromAndroctonus australis hector venom: Involvement of inflammatory lipid mediators

    Sassia SAMI-MERAH, Marie-France MARTIN-EAUCLAIRE, Fatima LARABA-DJEBARI

    USTHB, Faculty of Biological Sciences; Laboratory of Cellular and Molecular Biology, BP 32, El-Alia, Bab Ezzouar, Algiers, Algeria, and CNRS UMR3132 CRN2M, IFR Jean-Roche, Universit é de la M é diterran é e, Facult é de Médecine Nord, Bd Pierre Dramard, 13916, MARSEILLE, Cedex 20, France

    Protective effects of Cordia salicifolia Cham extract against the Bothrops jararacussu snake venom

    Raphael Schezaro-Ramos 1,2 , Rita de Cássia de Oliveira Collaço 1, José Carlos Cogo 3, Léa Rodrigues-Simioni 1, Priscila Randazzo-Moura 2

    1 Depto Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP, Campinas/SP, Brazil, 2 Lab. Farmacologia, Faculdade de Ciências Médicas e da Saúde, Pontifícia Universidade Católica – PUC/SP, Sorocaba/SP, Brazil, 3 Serpentário do Centro de Estudos da Natureza (CEN), Universidade do Vale do Paraíba - UNIVAP, São José dos Campos/SP, Brazil

    Purification of an antibacterial protein from the venom of the Egyptian cobraNaja haje

    Mohamed M. Tawfik 1,2, Patrick L. Harrison 2,Mohamed A. Abdel-Rahman 2,3, Keith Miller 2, Peter N. Strong 2

    1 Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt 2 Biomedical Research Centre, Biosciences Division, Sheffield Hallam University, Sheffield, UK.. 3 Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

    Next generation sequencing of the Malayan pit viper venom gland

    Whiteley G 1, Archer J 1., Casewell N 1,2, Rowley P, Wagstaff S 1 and Harrison R 1

    1 Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, and 2 School of Biological Sciences, Bangor University, Deiniol Rd, Bangor, UK

  • Organisations Represented at Venoms 2013

    The following organisations were represented at the symposium.

    • University of Science and Technology Houari Boumediene, Algeria
    • Snake Farm Czech, Czech Republic
    • IPMC-CNRS, France
    • University of Malaya, Malaysia
    • Queen’s University of Belfast, UK
    • BMRC Sheffield Hallam University, UK
    • University of Strathclyde, UK
    • Federal University of Uberlandia, Brazil
    • Universiti Kebangsaan Malaysia Medical Centre, Malaysia
    • Sao Paulo State University, Brazil
    • UMC Utrecht, The Netherlands
    • Instituto Butantan, Brazil
    • University of Padova, Italy
    • University of Frankfurt, Germany
    • Women’s & Children’s Hospital, North Adelaide, Australia
    • University Paris-Sud & MNHN-CNRS UMR7245, Paris, France
    • Liverpool School of Tropical Medicine, UK
    • Bangor University, UK
    • Hunan Normal University, Changsha, Hunan, China
    • Universidad Central de Venezuela, Caracas, Venezuela
    • University of Oxford, UK
    • University of Edinburgh, UK
    • Instituto de Biomedicina de Valencia, CSIC, Spain
    • Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS/UNS, France
    • Dublin City University, Ireland
    • Jožef Stefan Institute, Slovenia
    • University of Leuven (KU Leuven), Belgium
    • University Hospital Heidelberg, Germany
    • Biodiversity and Climate Research Centre (BiK-F), Germany
  • TBA

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