Venoms 2012

Distinguished Faculty

Professor Dr Juan Calvete
Professor and Laboratoty Head, Instituto de Biomedicina de Valencia, Valencia, Spain
Title: (Prote)omics in snake venom research-A mere academic exercise?

Dr Reto Stöcklin
President and CEO, Atheris Laboratories, Geneva, Switzerland
Title: CONCO: The first integrated venomics project

Mr Steven Trim
Director, Venomtech Ltd, UK
Title: Naturally compressed venom screening arrays

Professor Yuri Utkin
Professor and Laboratory Head, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Title: Novel toxins for nicotinic acetylcholine receptors

Dr Catherine Vulfius
Research Scientist, Institute of Cell Biophysics, Russian Academy of Sciences, Moscow, Russia
Title: Polypeptides from Viperidae snake venoms block acetylcholine-elicited current in Lymnaea stagnalis neurons

Dr Sergey Kozlov
Senior Research Scientist, Institute of Bioorganic Chemistry, Russia
Title: Natural compounds acting on ASIC3 receptor

Professor Dr Igor Križaj
Professor and Laboratory Head, Jožef Stefan Institute, Ljubljana, Slovenia
Title: Snake venom toxic phospholipases – valuable tools for dissecting activities of their mammalian orthologs

Keynote Address by Professor John B Harris
Emeritus Professor of Experimental Neurology, University of Newcastle-Upon-Tyne, UK
Title: Adventures with muscle

Dr Michela Rigoni
Research Scientist, Department of Biomedical Sciences, University of Padova, Padova, Italy
Title: Neuromuscular junction degeneration and regeneration following snake PLA2 neurotoxins poisoning

Professor Dr Frédéric Ducancel
Director, The Laboratory of Antibody Engineering for Health, CEA/iBiTecS/SPI/LIAS, France
Title: Sarafotoxins: Molecular diversity and engineering

Professor Antony Gomes
Professor, University of Calcutta, Kolkata, India
Title: Snake venom anti-cancer molecules – from folk medicine to reality

Professor Peter Strong
Professor and Laboratory Head, Sheffield Hallam University, Sheffield, UK
Title: Arthropod venom toxins: from biological tools to templates for clinical agents

Professor Dr Jan Tytgat
Professor and Laboratory Head, University of Leuven, Leuven, Belgium
Title: What can be learned from insect defensin-derived neurotoxins?

Dr Alan Wickenden
Scientific Director and Fellow, Janssen Research & Development LLC, San Diego, CA, USA
Title: The molecular basis of the interaction between Huwentoxin-IV (μ-TRTX-Hh2a) and the voltage-sensitive sodium channel, Nav1.7.

Dr Wafa Bouzid
Researcher, Centre Universitaire JFC, Toulouse, France
Title: First transcriptomic signature from ant gland venom of the speciesTetramorium bicarinatum (Myrmicinae)

Dr Vassili Lazarev
Chief of Gene Engineering Labs, Research Institute for Physico-Chemical Medicine, Moscow, Russia
Title: Arthropod venom peptides for gene therapy of intracellular bacterial infections

Dr Ulrich Kuch
Head, Biodiversity and Climate Research Centre (BiK-F), Frankfurt, Germany
Title: Snake bite diagnosis - what's the point?

Keynote Address by Professor David Warrell
Emeritus Professor of Tropical Medicine, University of Oxford, UK
Title: Making toxinological sense of the clinical effects of envenoming and poisoning

Professor David Lalloo
Professor of Tropical Medicine, Liverpool School of Tropical Medicine, UK
Title: Priorities and challenges of clinical envenoming research

Dr Anita Malhotra
Lecturer and Laboratory Head, Bangor University, Bangor, UK
Title: Exploring the treasure trove: Patterns of snake venom diversity from an evolutionary perspective

Dr Ana Mura Moura-da-Silva
Research Scientist, Instituto Butantan, SP, Brazil
Title: Processing of SVMPs: Detection of SVMP zymogens and pro-domain inBothrops jararaca venom and venom glands

Dr Nicolas Gilles
Research Scientist, Toxin, Receptor and Ion Channel Group, Institute of Biology and Technologies (iBiTEC-S), Gif sur Yvette, France
Title: G-protein-coupled receptors - an unexploited family of animal toxins targets: Exploration of green mamba venom for novel drug candidates

Miss Sanghamitra Mukherjee
Research Student, Maulana Azad College, Kolkata, India
Title : Bioactivity of a small molecular weight compound (NNSS2) from Naja najashed skin on estrous cycle of female albino mice

Poster Presented at Venoms 2012

(Presenters in Bold)

Transcriptome analysis of the venom gland of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae)

Mohamed Abdel-Rahman, Veronica Quintero Hernandez and Lourival D Possani

Comparative Functional Characterization of a Gyroxin-like Serine Protease from Crotalus durissus collilineatus in the Native and Recombinant Forms

Johara Boldrini-França; Renata Santos Rodrigues; Mário Sérgio Rocha Gomes; Dayane Lorena Naves de Souza; Karla de Castro Figueiredo Bordon; Veridiana de Melo Rodrigues; Eliane Candiani Arantes

STUDY OF MECHANISM OF ACTION OF BACTERIAL AND SCORPION NEUROTOXINS

Sadia Ashraf, Cesare Montecucco and Ornella Rossetto

Heterologous Expression of a Gyroxin Homologue Serine Protease fromCrotalus durissus collilineatus in Pichia pastoris

Johara Boldrini-França; Renata Santos Rodrigues; Ludier Kesser Santos-Silva; Flávio Henrique-Silva; Veridiana de Melo Rodrigues; Eliane Candiani Arantes

Use of gamma radiation to detoxify antigens: Safe approach to develop treatment for scorpion envenoming

Lila Boussag-Abib, Rebbouh Farah and Laraba-Djebari Fatima

The fibrinogen: A primary target of two therapeutic biomolecules newly isolated from the venom of Cerastes cerastes () and role of CC3-SPase inshortening of blood- clotting time of patient sera deficient in clotting factors

CHERIFI F, et LARABA-DJEBARI F

Neuromuscular blockade induced by Jaburetox (a recombinant peptide derived from Canavalia ensiformis urease) at In vivo cockroach nerve- muscle preparations

Cháriston André Dal Belo, Carlos Gabriel Moreira de Almeida, Paulo Marcos Pinto, Jaderson Costa DaCosta, Célia R. Carlini

Calpains are involved in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins

Duregotti E, Tedesco E, Montecucco C and Rigoni M

The PLA 2activity of myotoxins from Bothrops asper venom

Julian Fernandez, Paola Caccin, Grielof Koster, Bruno Lomonte, Jose Maria Gutierrez, Anthony D. Postle and Cesare Montecucco

VENOMICS, High-throughput peptidomics and transcriptomics of animal venoms for discovery of novel therapeutic peptides and innovative drug development

Nicolas Gilles, Gregory Upert, Alexandra Pastor, Denis Servent, Gilles Mourier

Isolation and Partial Characterization of a Hyaluronidase from Tityus serrulatus Venom

Fernanda Gobbi-Amorim; Karla de Castro Figueiredo Bordon; Eliane Candiani Arantes

The Identification and Characterisation of Antimicrobial Peptides from Snake Venom

Patrick Harrison, Thomas J Smith, Peter N Strong & Keith Miller

In vitro assessment of scorpion venom: Biochemical and morphological changes in immune cell lines

Hammoudi-Triki D, Khemili D, Bechohra L, Saidi H and Laraba-Djebari F

Involvement of Immunological markers with the severity of envenomation: Correlation with epidemiological data

Ishak Boushaki Wassila, Ladjel-Mendil Amina, Adi-Bessalem Sonia, Alamir Bouchra, Merad Rachida, Hammoudi-Triki Djalila and Fatima Laraba-Djebari

Clinical scoring system as a new device in deciding therapeutic dosage schedule for efficient use of anti-scorpion venom serum

Natu VS, Kamerkar SB, Geeta K, Vidya K, Natu V, Sane S, Kushte R, Thatte S, Uchil DA, Rege NN and Bapat RD

Investigating Ladybird Alkaloids as Potential Leads for Novel Insecticides

Richards DP, Mellor I, Duce I, Birkett M, Pickett J and Stockman R

Evaluation of the cytotoxicity and cell proliferation induced by the toxin BaPLA 2-IV on tumor cell lines

Adelia CO Cintra, Cássio P da Silva, Suely V Sampaio

Lebecin, a novel snalec from Macrovipera lebetina venom with anti-tumour activity on breast cancer cells (MDA-MB231)

Sameh Sarray, Jebali Jed, Fakhfekh Emna, Mohamed El Ayeb and Marrakchi Naziha

Hemostatic disturbances evoked by young and adult Bothrops jararaca snake venoms: Analysis of the envenoming process and the recovery after specific antivenin treatment

Luana V Senise, Sâmella S. Oliveira, Marcio Y. Yano, Savio S. Sant´Anna, Marcelo L. Santoro, Ida S. Sano-Martins

Involvement of Kaliotoxin in seizure disorders

Nesrine Sifi, Ladjel-Mendil Amina, Martin-Eauclaire Marie-France et, Laraba-Djebari Fatima

Hemostatic disorder and multiple organ failure following Echis pyramidumbite

Zdenek Stach , Jiri Valenta

Rosmarinic Acid as an Antivenom Compound in Argusia argentea and Antivenom Activity of Its Analogues

Yoshiaki Takaya, Hnin Thanda Aung, Toshiaki Nikai, Yumiko Komori, Tsunemasa Nonogaki, Masatake Niwa

Snakebites in Czech Republic - Epidemiological and clinical aspects in 12 years (2000 – 2011)

Jiri Valenta, Zdenek Stach

Do mitochondrial Alarmins released by snake envenomations trigger inflammation?

Maria Vono , Irene Zornetta, Paola Caccin, Bruno Lomonte, Josè M Gutierrez and Cesare Montecucco