Phages 2013

See you at Phages 2014
16-18 September 2014, Oxford, UK

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  • Phages 2013 Summary

    Bacteriophage in Medicine, Food and Biotechnology

    10-12 September 2013, St Hilda's College, Oxford, UK

    Welcome to the Oxford Bacteriophage Conference, Phages 2013. The conference addressed commercial and research applications of bacteriophage in medicine, food and biotechnology, and covered a variety of topic, including pharmaceutical production and formulation, medical applications, immunogenicity and toxicology, applications in biotechnology, food technology and bacteriophage molecular biology.

    Keynote Speakers:
    • Prof John McCafferty
    • Dr Herald Brüssow
    • Prof Peixuan Guo

  • Distinguished Speakers

    Professor Dr Martin J Loessner
    Professor of Microbiology, Institute of Food, Nutrition and Health, Zürich, Switzerland
    Title: Cool tools from the virus - exploiting phage for highly specific killing and diagnostics of pathogenic bacteria

    Professor Dr Andrzej Gorski
    Institute of Immunology & Experimental Therapy, Polish Academy of Sciences, Wroclaw/The Medical University of Warsaw, Poland, and Vice-President of the Polish Academy of Sciences, Poland
    Title: Clinical and immunological aspects of phage therapy

    Dr Stefan Miller
    CSO, Lisando GmbH, Germany
    Title: Artilysins: Antibacterial enzymes that attack bacterial surface structures

    Dr Harald Brüssow (Keynote Address)
    Senior Scientist, Nestle, Switzerland
    Title: Controlled treatment trial of Escherichia coli diarrhea with two phage cocktails: Experience with 100 enrolled children

    Dr Andrey Aleshkin
    Head, Clinical Microbiology and Biotechnology of Bacteriophages Laboratory, Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russia
    Title: Reducing Salmonella contamination in poultry products using phages

    Miss Patricia Perez Esteban (Short presentation)
    Graduate Research Student, University of Bath, UK
    Title: Stabilisation of bacteriophage-k in oil-in-water nano-emulsions for the treatment of burn wound infections

    Professor Dr Inger Sandlie
    Professor and Group Head, Centre for Immune Regulation, University of Oslo, Oslo, Norway
    Title: Next generation phage display by use of pVII and pIX

    Professor Dr Stefan Dübel
    Director, Technische Universität Braunschweig, Institute of Biochemistry, Biotechnology and Bioinformatics, Germany
    Title: Phage display for vaccine candidate identification coupled to rapid/high throughput Yumab generation

    Professor Dr Uwe Haberkorn
    Professor of Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    Title: Phage display methods for the identification of tumor affine peptides

    Professor John McCafferty (Keynote Address)
    Professor of Biochemistry, University of Cambridge and IONTAS Ltd, UK
    Title: Generation of antibodies for research and medicine by phage display technology

    Dr Richard Hopkins
    CSO and COO, Phylogica Ltd, Australia
    Title: Phylomer libraries as a rich source of novel cell penetrating peptides

    Mr Johan Seijsing (Short presentation)
    Graduate Research Student, Royal Institute of Technology, AlbaNova University Center, Stockholm, Sweden
    Title:
    Phage display selection of highly pH dependent fusion tags binding to the neonatal Fc receptor for extended serum circulation half-life of biopharmaceuticals in vivo

    Dr Edward Taylor
    Research Fellow, University of Lincoln, Brayford Pool, Lincoln, UK
    Title: The SF370.1 prophage of Streptococcus pyogenes and strategies for survival within the human host

    Professor Dr Grzegorz Wegrzyn
    Professor and Head, Department of Molecular Biology, and Pro-Rector of Scientific Affairs, University of Gdańsk, Gdańsk, Poland
    Title: Inhibition of development of Shiga toxin-converting bacteriophages andstx gene expression by factors inducing the stringent response in Escherichia coli

    Professor Maggie Smith
    Microbiology Chair, Department of Biology, University of York, UK
    Title: Applications of phage integrases in Streptomyces spp. and beyond

    Professor Peixuan Guo (Keynote Address)
    William Farish Endowed Chair in Nanobiotechnology,Director of Nanobiotechnology Center, University of Kentucky, KY, USA
    Title: Single Molecule Detection, Single Pore DNA Sequencing, Bioreactors and Therapeutics Delivery Using Bacteriophage Phi29 DNA-Packaging Motor that Revolves without Rotation

    Dr Shuhei Hashiguchi
    Graduate School of Science and Engineering, Kagoshima University, Japan
    Title: M13 bacteriophage as a vaccine vehicle

    Dr Heather Allison
    Senior Lecturer, School of Biological Sciences, University of Liverpool, UK
    Title: Stx phages: What are they and what can they do?

    Miss Inga Eichhorn (Short presentation)
    Graduate Research Student
    , Free University Berlin, Germany
    Title: Transduction of identical atypical enteropathogenic E. coli (aEPEC) from different hosts with a Shiga Toxin-converting bacteriophage – The role of aEPEC as pre-EHEC

    Dr Catherine Rees
    Associate Professor of Microbiology
    , University of Nottingham, UK
    Title: Progress with phage-based detection methods

    Dr Eli Keshavarz-Moore
    Professor of Bioprocess Science and Enterprise, The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, UK
    Title: Bioprocessing challenges in production of M13 phage and potential solutions

    Dr Tony Hitchcock
    Cobra Biologics, UK
    Title: Analytical requirements for clinical manufacturing programmes

    Dr Lidija Urbas
    Chief Marketing Officer, BIA Separations, Slovenia
    Title: Purification approaches for production of bacteriophages using methacrylate based monolithic columns

    Dr Marcin Los
    Phage Consultants, Poland
    Title: Commercial scale bacteriophage processes. Look before you leap!

    Dr Emma Bell
    Fixed-Phage Ltd, UK
    Title: Increasing bacteriophage robustness in hostile environments

    Professor Rimantas Daugelavičius
    Department of Biochemistry and Biotechnologies, Vytautas Magnus university, Lithuania
    Title: Express-analysis of bacteria-phage interaction

  • Posters Presented at Phages 2013

    Phage-mediated biocontrol of ground beef artificially contaminated with E. coli

    Aleshkin A.V. , Volozhantsev 2 N.V., Svetoch 2 E.A., Verevkin 2 V.V., Kiseleva 1 I.A., Popova 2 A.V., Afanas’ev 1 S.S.

    1 Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russia, 2State Research Center for Applied Microbiology & Biotechnology (Obolensk), Russia

    What bacteriophages do in a starter culture

    Maciek Spus, Svetlana Alexeeva, Judith Wolkers-Rooijackers, Tjakko Abee, Eddy J. Smid

    TI Food and Nutrition P.O. Box 557 6700 AN Wageningen, The Netherlands, Wageningen UR, Postbus 9101, 6700 HB Wageningen, The Netherlands

    Isolation of a bacteriophage cocktail effective on the eradication of Staphylococcus aureus biofilms

    Diana Alves 1,2 , David R. Harper 1, Mark C. Enright 2, Toby Jenkins 2

    1 Ampliphi Biosciences Corp., Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK, 2Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK

    Development of hydrogel burn wound dressings as triggered release platforms for lysostaphin and bacteriophage lysins

    J E Bean , ATA Jenkins

    Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

    Isolation and characterization of bacteriophages from Danish sourdough

    Dalia Cizeikiene 1,4 , Witold Kot 2, Musemma K. Muhammed 1, Horst Neve 3, Lars H. Hansen 2, Søren J. Sørensen 2, Knut J. Heller 3, Grazina Juodeikiene 4, Dennis S. Nielsen 1 and Finn K. Vogensen 1

    1,4 Department of Food Science, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark, 2 Department of Biology, University of Copenhagen, Universitetsparken 15, DK-2100 Copenhagen Ø, Denmark, 3 Department of Microbiology and Biotechnology, Max Rubner-Institut, Hermann-Weighmann-Str. 1, D-24103 Kiel, Germany, 4 Department of Food Technology, Faculty of Chemical Technology, Kaunas University of Technology, Radvilenu road 19, LT-50254 Kaunas, Lithuania

    Genomic characteristic of PS44 - a new member of Pseudomonas aeruginosa PB1-like phages

    Kamil Dąbrowski 1, Aleksandra Głowacka 1, Monika S. Hejnowicz 1, Beata Weber-Dąbrowska 2 and Małgorzata Łobocka 1,3

    1 Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland, 2 Laboratory of Bacteriophages, Hirszfeld Institute of Immunology and Experimental Therapy, PAS, Wrocław, Poland, 3Autonomous Department of Microbial Biology, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw, Poland

    Phage display affinity maturation for improved pharmacokinetics and tumor imaging of an ErBB2-targeted peptide

    Benjamin Larimer 1, Jeanne Quinn 1, Thomas P. Quinn 1, and Susan L. Deutscher 1,2

    1Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA, 2Harry S Truman Memorial Veterans Hospital, Columbia, MO 65210

    The impact of temperate bacterial viruses on the microbiota of chronic respiratory disease

    Francesca LC Everest § 1, Mohammad A Tariq § 1, Bartosz Roszniowski 2, Clare Lanyon 1, Anthony De Soyza 3, Audrey Perry 3, John Perry 3, Stephen Cummings 1 and Darren L Smith 1

    § Authors contributed evenly to the work

    1 Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK, 2Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Poland, 3Freeman Hospital, Newcastle Upon Tyne, UK and Newcastle University, Newcastle Upon Tyne, UK

    Genomic characteristic of PS9N - a new member of Pseudomonas aeruginosa phi73-like phages

    Aleksandra Głowacka 1 , Kamil Dąbrowski 1, Monika S. Hejnowicz 1, Beata Weber-Dąbrowska 2 and Małgorzata Łobocka 1,3,

    1 Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland; 2 Laboratory of Bacteriophages, Hirszfeld Institute of Immunology and Experimental Therapy, PAS, Wrocław, Poland; 3 Autonomous Department of Microbial Biology, Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw, Poland

    The effectiveness of bacteriophage therapy of inflammatory diseases of the reproductive tract

    Anatoliy P Godovalov 1 , Liliya P Bykova 1, Tatyana Yu Danielyan 2

    1 immunology and microbiology department, Acad. E.A. Wagner Perm State Medical Academy, Perm, 26, Petropavlovskaya street, 614990, Russian Federation, 2Medical studio LLC, Perm, 11, Dekabristov street, 614990, Russian Federation

    The E.6 gene as a putative player in bacteriophage T4 development

    Piotr Golec 1 , Katarzyna Kwaśnicka 2, Joanna Karczewska-Golec 2, Grzegorz Węgrzyn 2

    1 Laboratory of Molecular Biology (affiliated with the University of Gda n sk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Wita Stwosza 59, 80-308 Gdan sk, Poland, 2 Department of Molecular Biology, University of Gda n sk, Wita Stwosza 59, 80-822 Gdan sk, Poland

    Common Mechanisms of biomotors in bacteriophage, bacteria, and Cell seminar to the Earth revolves around the Sun

    Zhengyi Zhao, Chad Schwartz and Peixuan Guo

    Nanobiotechnology Center, University of Kentucky, Lexington, USA

    Bacteriophage RNA as ultras table and temperature resistant materials to build nanoparticles with defined size, structure, stoichiometry as therapeutics

    Emil Khisamutdinov, Daniel Jasinski, Farzin Haque, Dan Shu, Yi Shu, Zhengyi Zhao, Chad Schwartz and Peixuan Guo

    Nanobiotechnology Center, University of Kentucky, Lexington, USA

    The activity of Bacillus anthracis phages endolysines on other Bacillus spp. strains

    Romuald Gryko, Lidia Mizak, Aleksandra Nakonieczna, Sylwia Parasion, Magdalena Kwiatek and Marcin Niemcewic

    Military Institute of Hygiene and Epidemiology, Biological Threat Identification and Countermeasure Centre, Lubelska 2, 24-100 Pulawy, Poland

    A new rapid method for genome sequencing of bacteriophages from a single plaque

    Witold Kot 1 , Finn K. Vogensen 2, Søren J. Sørensen 1 and Lars H. Hansen 1

    1 Department of Biology, Faculty of Science, University of Copenhagen, Universitetsparken 15, DK-2100 København Ø, Denmark, 2Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark

    Characterization of the new isolated bacteriophages lytic againstPseudomonas aeruginosa clinical strains

    Magdalena Kwiatek 1 * , Lidia Mizak 1, Sylwia Parasion 1, Beata Chudzik-Rząd 2, Anna Malm 2, Romuald Gryko 1, Marcin Niemcewicz 1, Alina Olender 3

    1. Military Institute of Hygiene and Epidemiology, Biological Threat Identification and Countermeasure Centre, Lubelska 2, 24-100 Pulawy, Poland, 2. Medical University of Lublin, Department of Pharmaceutical Microbiology, dr W. Chodzki 1, 20-093 Lublin, Poland, 3. Medical University of Lublin, Department of Medical Microbiology, dr W. Chodzki 1, 20-093 Lublin, Poland

    Harnessing bacteriophages against antibiotic-resistance conferring genetic elements

    Sari Mattila, Ville Ojala, Ville Hoikkala, Jaana Bamford, Matti Jalasvuori

    Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland

    Exploitation of bacteriophage ΦCD27 for the control of Clostridium difficile

    M. J. Mayer 1 , E. Meader 1,, M.D. Webb 1, V. Garefaliki 2, R. Spoerl 2, R. Meijers 2, A. Narbad 1

    1 Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK, 2EMBL Hamburg Outstation, EMBL c/o Desy, Notkestraße 85, D-22603 Hamburg, Germany

    Metagenome Analysis of Bacteriophage Communities in European Dairies Using Defined and Undefined Mesophilic Starter Cultures

    Musemma K. Muhammed 1 , Witold Kot 2, Lars H. Hansen 2, D. S. Nielsen 1, Søren J. Sørensen 3, Horst Neve 4, Knut J. Heller 4 , Jennifer Mahony 5, Douwe van Sinderen 5, Finn K. Vogensen 1

    1 Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark, 2Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen Ø, Denmark, 3Arla Foods A/S, 4Department of Microbiology and Biotechnology, Max Rubner-Institut, Kiel, Germany, 5 Department of Microbiology, University College Cork, Cork Ireland

    Control of bacteriophage lambda development using synthetic small regulatory RNAs

    Dariusz Nowicki, Grzegorz Węgrzyn, Agnieszka Szalewska-Pałasz

    Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-822 Gdańsk, Poland

    Isolation and characterization of six lytic phages with therapeutic potential against clinical strains of A cinetobacter baumannii

    Sylwia Parasion 1, Magdalena Kwiatek 1, Beata Chudzik-Rząd 2, Lidia Mizak 1, Anna Malm 2, Romuald Gryko 1, Marcin Niemcewicz 1

    1. Military Institute of Hygiene and Epidemiology, Biological Threat Identification and Countermeasure Centre, Lubelska 2, 24-100 Pulawy, Poland, 2. Medical University of Lublin, Department of Pharmaceutical Microbiology, dr W. Chodzki 1, 20-093 Lublin, Poland

    In vivo phage display selection and characterization of a novel targeted peptide for aggressive breast cancer detection

    Thomas P. Quinn 1, Benjamin Larimer 1, and Susan L. Deutscher 1,2

    1Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA; 2Harry S Truman Memorial Veterans’ Hospital, Columbia, MO 65210

    Biolyse PB: A novel bacteriophage treatment to control soft rot development in packed vegetables

    Sarah Shrimpton, Sabina Badja, Kiri Mack & Alison Blackwell

    Advanced Pest Solutions Ltd., Prospect House Business Centre, Dundee Technology Park, Dundee, DD2 1TY, UK

    Characterization of Phage Receptor Binding and DNA Ejection via Tailspike Proteins

    Dorothee Andres 1,2, Anaït Seul 1, Nina K Broeker 1, Eva Stettner 1, Stefanie Barbirz 1, and Robert Seckler 1

    1Potsdam University, Physical Biochemistry, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany, 2 present address Harvard University, Dept. of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 02138, USA

    Fusion of the endolysin Lyt µ1/6 C-terminal domain with the GFP to visualise its binding activity

    Tisakova L 1* , Farkasovska J 1, Godany A 1, 2

    1 Institute of Molecular Biology, Slovak Academy of Sciences, SK-84551, Bratislava, Slovakia, 2University of SS. Cyril and Methodius in Trnava, Faculty of Natural Sciences, Department of Biotechnology, Nam. J. Herdu, SK-917 01, Trnava, Slovakia

    Application of phage-mediated bioprocessing in decontamination of dairy products

    Vanyan 1A.L. , Bochkareva 1 S.S., Aleshkin 2 A.V., Volozhantsev 3 N.V., Svetoch 3 E.A., Afanas’ev 2 S.S.

    1 Bphage LLC, Moscow, Russia, 2 Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russia, 3State Research Center for Applied Microbiology & Biotechnology, Obolensk, Russia

    Endolysin catalytic domains - in silico analysis of amino acid residues important for protein-substrate interaction

    Vidova B 1, Tisakova L 1, Sramkova Z 1, Godany A 1, 2

    1 Institute of Molecular Biology SAS, SK-84551 Bratislava, Slovakia, 2 Faculty of Natural Sciences, University of SS Cyril and Methodius in Trnava, SK-91701 Trnava, Slovakia

    Virus-like particles in a lab-scale anaerobic digester

    Hongyun Zhu 1 , Bärbel Kiesel 1, Gerd Hause 2, Babett Arnold 1, Sabine Kleinsteuber 1

    1 Department of Environmental Microbiology, Helmholtz Centre for Environmental Research – UFZ, Permoserstrasse 15, D-04318 Leipzig, Germany, 2Biocentre, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, D-06120 Halle, Germany

  • Who Attended Phages 2013

    The following organisations are being represented at the conference to-date. If you would like to get in touch with representative of an particular organisation before or during the conference, please let us know.

    • Advanced Pest Solutions Ltd, UK
    • Ampliphi Biosciences, UK
    • BASF - The Chemical Company, USA
    • BIA Separations, Slovenia
    • BigDNA Ltd, UK
    • Bphage LLC, Russia
    • Center for Environmental Research-UFZ, Germany
    • Cobra Biologics, UK
    • Fixed-Phage Ltd, UK
    • Free University Berlin
    • Free University Berlin, Germany
    • Argenta Discovery (Galapagos), UK
    • Gabrichevsky Moscow Research Institute of Epidemiology & Microbiology, Russia
    • German Cancer Research Center, Heidelberg, Germany
    • Institute of Food Research
    • Institute of Food, Nutrition and Health, Zürich, Switzerland
    • Institute of Hygiene & Epidemiology, Poland
    • Institute of Immunology & Experimental Therapy, Poland
    • IONTAS Ltd, UK
    • Kagoshima University, Japan
    • Kauno Technologijos Universitetas, Lithuania
    • Lisando GmbH, Germany
    • Lomonosov Moscow State University, Russia
    • Nestle, Switzerland
    • Phage Consultants, Poland
    • Phylogica Ltd, Australia
    • Polish Academy of Sciences, Poland
    • Potsdam University, Germany
    • PTC Phage Technology Center GmbH
    • Renaissance Biological Solutions, Canada
    • Rïgas Stradina Universitate, Latvia
    • Royal Institute of Technology, Sweden
    • Russian Academy of Sciences, Russia
    • School of Life Sciences, University of Warwick
    • Synthetic Genomics, USA
    • Technische Universität Braunschweig, Germany
    • Texas A&M University, USA
    • UMB SAV, Slovakia
    • University of Bath
    • University of Cambridge
    • University of Copenhagen, Denmark
    • University of Gdansk, Poland
    • University of Heidelberg, Germany
    • University of Kentucky, USA
    • University of Lincoln, UK
    • University of Liverpool, UK
    • University of Missouri, USA
    • University of Northumbria, UK
    • University of Nottingham, UK
    • University of Oslo, Norway
    • University of York, UK
    • Vytautas Magnus university, Lithuania
    • Wagner Perm State Medical Academy, Russia
    • WUR, The Netherlands

  • Exhibitor

    Cobra Biologics is a leading international contract manufacturing organisation (CMO) of biologics and pharmaceuticals for clinical and commercial supply. Cobra has three GMP approved facilities, each with expertise tailored to serving our customers across the world. We offer a broad range of integrated and stand-alone contract services, stretching from cell line and process development through to fill and finish for the supply of investigational medicinal products and commercial production. We take pride in manufacturing excellence and being a trusted provider, delivering what we promise and helping our customers to develop medicines for the benefit of patients. Cobra Biologics provides manufacturing solutions to the pharmaceutical industry covering antibodies, recombinant proteins, viruses, phage, DNA, whole cell vaccines and therapeutics as well as biologics and small molecule API lyophilisation and fill finish.


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