Guidelines  for poster preparation and presentation

Kubo IST2015 Poster

Sanz IST2015 Poster

Thank you for considering to present your work as a poster at IST 2015 Oxford. Please carefully read and follow the instructions below:

Maximum capacity: 150 Posters

>The maximum size of your poster must not exceed A0, portrait format. Further information about poster sizes can be found on: http://tinyurl.com/y7bf and http://www.papersizes.org/a-paper-sizes.htm
>Do not prepare your poster in landscape format, as it may be rejected. Posters larger than A0 or those in landscape format WILL NOT be displayed.
>Do not laminate your poster or use heavy printing material. You may print on cloth. (Where can I print my poster in Oxford?)
>Consider including your photo on the poster to help delegates identify the presenter, as well as your postal and email addresses.
>Please ensure you have appropriate permissions for the publication of your abstract from the original copyright holders. Should you wish your abstract not to be published on the website or in the congress handbook, please notify us in writing at the time of abstract submission (see copyright information).
>All posters will be displayed in the North Schools.
>See the key below for your presentation date. Please note, we are unable to change the date of your poster presentation.
>Display your poster in the morning of your presentation date on your allocated poster board ONLY, ready for viewing during the first refreshment break.
>Stay close to your poster during breaks to answer any questions.
>Remove your poster during the afternoon coffee break. Any remaining posters will be discarded.

 

Accepted Posters

Titles of accepted poster abstracts will be displayed below.

(Presenters in Bold)

If your abstract has been accepted for presentation but it does not appear in the list below, please let us know as soon as possible by email on ist2015@lpmhealthcare.com.

Session 1:  Natural toxins and drug discovery – 26th September

26-1-1: Production of human monoclonal antibodies (scFv) able to   inhibit toxic actions of crude venom, purified melittin and PLA₂ from Africanized bees

Gabriela Pessenda¹, Luciano C Silva¹, Eduardo C Roncolato¹, Lucas B Campos¹, Elenice A Macedo¹, Manuela B Pucca², José E Barbosa¹

¹Medical School of Ribeirão Preto, University of São Paulo – Ribeirão Preto, Brazil

²School of Pharmaceutical Sicences of Ribeirão Preto, University of São Paulo – Ribeirão Preto, Brazil

26-1-2: Effects of pinnatoxins and other cyclic imine phycotoxins on the mouse neuromuscular system in vivo

Evelyne Benoit^1,2, Armen Zakarian³, Jordi Molgó^1,2

¹Institut des Neurosciences Paris-Saclay, UMR 9197, CNRS, 91190 Gif-sur-Yvette, France

²Service d’Ingénierie Moléculaire des Protéines (DSV/iBiTec-S/SIMOPRO), CEA de Saclay, 91191 Gif-sur-Yvette, France

³Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA

26-1-3: Neurotoxicity of Jack Bean Urease: Investigation of its convulsive-like activity

Cháriston A. Dal Belo^1,2, Carlos G. Moreira de Almeida¹, Douglas S. Santos², Louise Wilson⁵, Paulo M. Pinto¹, Lúcia Vinadé¹,  Jaderson C. DaCosta³, Célia R. Carlini^3,4, Trevor J. Bushell⁵

¹LANETOX, Federal University of Pampa (UNIPAMPA), Campus São Gabriel, Av. Antônio Trilha, 1847, Centro, São Gabriel, 97300-000, RS, Brazil

²PPGBioTox, Universidade Federal de Santa Maria, Santa Maria, Brazil

³Laboratory of Neurosciences, Institute of Biomedical Research and Brain Institute (InsCer), Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil

⁴LaNeurotox, Brain Institute (InsCer) and Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS 90619-900, Brazil

⁵Strathclyde Institute of Pharmacy and Biomedical Sciences, Robertson Trust Wing, Strathclyde University, Glasgow UK

26-1-4: Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a

Miguel Salinas^1,2, Thomas Besson^1,2, Quentin Delettre^1,2, Sylvie Diochot^1,2, Sonia Boulakirba^1,2, Dominique Douguet^1,2, And Eric Lingueglia^1,2

¹CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France

²Université de Nice Sophia Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des Lucioles, 06560 Valbonne, France, and LabEx Ion Channel Science and Therapeutics, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS and Université de Nice Sophia Antipolis, 660 route des Lucioles, 06560 Valbonne, France

26-1-5: A prothrombin activator protein and derived peptides as promising tissue remodeling agents

Cicilia de Carvalho¹, Kerly Fernanda Mesquita Pasqualoto¹, Linda Christian Carrijo-Carvalho², Eduardo Reis³, Ana Carolina Ayupe³, Ana Marisa Chudzinski-Tavassi¹

¹Laboratory of Biochemistry and Biophisycs, Butantan Institute, São Paulo, SP, Brazil

²Department of Ophthamology, Federal University of São Paulo

³Chemistry Institute, State University of São Paulo, São Paulo, SP, Brazil

26-1-6: Ts19 Fragment II: a new long-chain potassium channel toxin from Tityus serrulatus venom

Felipe Augusto Cerni¹, Manuela Berto Pucca¹, Fernanda Gobbi Amorim¹, Karla de Castro Figueiredo Bordon¹, Julien Echterbille², Loïc Quinton², Edwin De Pauw², Steve Peigneur³, Jan Tytgat³, Eliane Candiani Arantes¹

¹Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil

²Laboratory of Mass Spectrometry, Department of Chemistry, University of Liège, Allée de la chimie 6, B6c, B-4000 Liège, Belgium

³Toxicology and Pharmacology, University of Leuven, O&N 2, Herestraat 49, P.O. Box 922, 3000, Leuven, Belgium

26-1-7: Structure and molecular mode of action of a snake toxin acting on type 2 vasopressin receptor

Laura Droctové¹, Justyna Ciolek, Enrico A. Stura¹, Laura Vera¹, Fabrice Beau¹, Jan Tytgat², Steve Peigneur², Denis Servent¹, Gilles Mourier¹, Nicolas Gilles¹

¹CEA Saclay, iBiTec-S, SIMOPRO, 91191 Gif sur Yvette, France

²Laboratory of Toxicology, University of Leuven (KU Leuven), Campus Gasthuisberg O&N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium

26-1-8: Placolin, a new inhibitor of platelet aggregation from Haementeria depressa leech

Jafia Lacerda-Alves¹, Janaina S Ventura¹, Marcelo L Santoro², Nicole C Mambelli¹, Ana M Chudzinski-Tavassi¹, Fernanda Faria¹

¹Laboratório de Bioquímica e Biofísica – Instituto Butantan, São Paulo, Brazil

²Laboratório de Fisiopatologia – Instituto Butantan, São Paulo, Brazil

26-1-9: Structural characterization of a novel peptide with antimicrobial and anticancer activities from the venom gland of the scorpion Tityus stigmurus

Edinara T Melo¹; Andréia B Estrela¹; Elizabeth C Gomes Santos¹; Paula R L Machado²; Kleber J S Farias²; Taffarel M Torres³; Enéas Carvalho⁴; João P M S Lima⁵; Arnóbio A Silva-Júnior¹; Euzébio G Barbosa⁶; Matheus F Fernandes-Pedrosa¹

¹Laboratório de Tecnologia e Biotecnologia Farmacêutica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil

²Laboratório de Imunologia Clínica, Universidade Federal do Rio Grande do Norte, RN, Brazil

³Departamento de Ciências Animais, Universidade Federal Rural do Semi-Árido, Mossoró, RN, Brazil

⁴Centro de Biotecnologia, Instituto Butantan, São Paulo, SP, Brazil e

⁵Programa de Pós-Graduação em Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil

⁶Laboratório de Química Farmacêutica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil

26-1-10: Identification of C-type isolectins in the venom of the scorpionfish Scorpaena plumieri

Filipe Andrich^1,2, Gustavo B Naumann^1,3, Michael Richardson³, Marta N Cordeiro³, Daniel M Santos⁴, Gabriela G Montandon^2,4, Alfredo M Goes⁴, Maria Elena de Lima^2,4, Suely G Figueiredo¹

¹Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

²Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

³Diretoria do Centro de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, MG, Brazil

⁴Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

26-1-11: Scorpaena plumieri VENOM AND SKIN MUCUS: BIOCHEMICAL AND PHARMACOLOGICAL FEATURES

Thiago N. Menezes¹, Pedro F.Malacarne¹,Gustavo B. Naumann^1,2, Alan B. Mendonça¹, Helena L. Gomes¹, Jaqueline Leal², Márcia H. Borges², Suely G. Figueiredo¹

¹Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

²Diretoria do Centro de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, MG, Brazil

26-1-12: Identification and characterization of a peptide with anti-nociceptive effect isolated from the skin secretion of an American veined tree frog

Francia García¹, Ligia Corrales-García², Timoteo Olamendi-Portugal¹, Ernesto Ortiz¹, Gabriel Sandoval³, Gerardo Corzo¹

¹Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, UNAM. Apartado Postal 510-3, Cuernavaca Morelos, 61500, México.

²Departamento de Alimentos, Facultad de Química Farmacéutica, Universidad de Antoquia. AA 1226 Medellín–Colombia.

³Laboratorios Silanes S.A. de C.V., Amores 1304, Col. Del Valle, México

26-1-13: Primary structure of a proteinaceous toxin from rabbitfish Siganus fuscescens

Aya Kiriake, Yuji Nagashima, Kazuo Shiomi

Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Konan-4, Minato-ku, Tokyo 108-8477, Japan

26-1-14: High-throughput approach for isolation and identification of novel peptides with anticancer activities from scorpion venoms

Bin Li¹, Xinping Xi¹, Tianbao Chen², Chris Shaw² & Hang Fai Kwok^1,2

¹Faculty of Health Sciences, University of Macau, Avenida de Universidade, Macau SAR

²School of Pharmacy, Queen’s University Belfast, UK BT9 7BL

26-1-15: Purification, isolation and partial characterization of four dimeric disintegrins from the venom of Broad-Banded and Trans-Pecos Copperheads

Sara E Lucena¹, Montamas Suntravas¹, Elyse Grilli¹, Ifunanya Ogbata¹, Robert Walls¹, Andrea Alfonso³, Amber Goins³, Alexis Rodríguez-Acosta⁴, Elda E Sanchez^1,2

 ¹National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA

²Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX 78363, USA

³Biology Department, Del Mar College, 101 Baldwin Blvd., Corpus Christi, TX 78404, USA

⁴Laboratorio de Inmunoquímica y Ultraestructura, Instituto Anatómico de la Universidad Central de Venezuela, Caracas 1041, Venezuela

26-1-16: Caspase3/7-related apoptosis induced by two synthetic disulfide bond toxins from Conus californicus in lung cancer cell lines

Irasema Oroz-Parra¹, Alexei F Licea-Navarro¹, Mario Navarro-Armenta²

¹Department of Biomedical Innovation, Center of Scientific Research and Higher Education at Ensenada. Ensenada, Baja California, México.

²Department of Cell Death and Survival Networks, Stanford Burnham Medical Research Institute. La Jolla, United States

26-1-17: Tityus serrulatus toxins as immunosuppressants: insights of a novel K⁺ channel pattern in T cells

Manuela Berto Pucca¹, Thaís Barboza Bertolini², Felipe Augusto Cerni¹, Karla de Castro Figueiredo Bordon¹, Steve Peigneur³, Jan Tytgat³, Vânia Luiza Bonato², Eliane Candiani Arantes¹

¹ Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil

²Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil

³Toxicology and Pharmacology, University of Leuven, O&N 2, Herestraat 49, P.O. Box 922, 3000, Leuven, Belgium

26-1-18: Neutralization of Naja kaouthia venom induced acute stress and cytokines response with herbal gold nano particle (VN-GNP)

Kalyani Saha and Antony Gomes

Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, APC road, Kolkata 700009, West Bengal, India

26-1-19: Endophytic Paenibacillus terrae can produce toxic effect in promastigotes forms of Leishmania infantum/chagasi nitric oxide sensitive

Débora M Lins¹, Joice M A Rodolpho¹, Luis H Romano¹, Mauricio G Zaia¹, Sergio Albuquerquev, Fernanda F Anibal¹, Cristina P Sousa¹

¹Department of Morphology and Pathology, Universidade Federal de São Carlos – São Carlos (SP) – Brazil

²Pharmaceutical Sciences Faculty, Universidade de São Paulo, Ribeirão Preto (SP), Brazil

26-1-20: Cytotoxic properties of Smp24 and Smp43, alpha-helical antimicrobial peptides from the Egyptian scorpion, Scorpio maurus palmatus

Mohamed M. Tawfik^1,2, Ranwa  A. Elrayess^1,3, Patrick L. Harrison¹, Mohamed Abdel-Rahman³, Peter N. Strong¹  and Keith Miller¹

¹Biomedical Research Centre, Biosciences Division, City Campus, Sheffield Hallam University , Howard Street, Sheffield, S1 1WB, UK

²Zoology Department, Faculty of Science, Port Said University, Port Said, Egypt

³Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

26-1-21: The research and application results of sero-therapy for snake bite patients in Vietnam

Kiem X Trinh, Quyen K Le, Long X Trinh

Vietnam Society on Toxicology (VST), Vietnam

26-1-22: Structure-function relationship of Calcins, a group of high-affinity membrane-permeable peptide ligands of Ca²⁺ release channels/Ryanodine Receptors

Héctor H. Valdivia¹, Liang-Xiao¹, Carmen R. Valdivia¹, Georgina B Gurrola^1,2, and Lourival D Possani²

¹Center for Arrhythmia Res, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

²Instituto de Biotecnología, Univ Nacional Autónoma de México, Cuernavaca, Morelos, 06910 MEXICO

26-1-23: Superantigens in sepsis: effective treatment of staphylococcal enterotoxin B intoxication in the mouse

Sarah J Whitfield, Dr Jane E Risdall, Dr Gareth Griffiths and Dr Alun Carter

DSTL Porton Down, CBR Division, Salisbury, Wiltshire, SP4 0JQ, UK

29-1-24: Effects of BaP1, a P-I haemorrhagic metalloproteinase from Bothrops asper snake venom, on cremaster muscle vasculature: a model using confocal microscopy

Cristina Herrera^1,2, Mathieu-Benoit Voisin³, Teresa Escalante², Alexandra Rucavado², Sussan Nourshargh³, José María Gutiérrez²

¹Facultad de Farmacia, Universidad de Costa Rica, San José Costa Rica

²Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José Costa Rica

³William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

 

Session 3: Proteomics, venomics, antivenomics – 28th September

28-3-1: Global profile of the venom of Grammostola Iheringi Brazilian tarantula: searching for biotechnological potential

Márcia H Borges¹; Suely G Figueiredo²; Felipe V Leprevost³; Maria Elena De Lima⁴; Marta N Cordeiro¹; Marcelo R V Diniz¹; James J Moresco⁵; Paulo C Carvalho3; John Yates⁵

¹Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil

²Federal University of Espírito Santo, Vitoria, ES, Brazil

³Oswaldo Cruz Foundation, Fiocruz, Curitiba, PR, Brazil

⁴Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

⁵The Scripps Research Institute, San Diego, CA, United States

28-3-2: Multi-analytical method to characterise Naja atra venom

Michel Degueldre, Cédric H Delvaux, Johann Far, Loïc Quinton and Edwin De Pauw

Laboratory of mass spectrometry, University of Liege, Belgium

28-3-3: High-throughput epitope identification for snakebite antivenom

Mikael Engmark¹, Federico De Masi¹, Andreas Laustsen², José María Gutiérrez³, Bruno Lomonte³, Mikael Rørdam Andersen¹, Ole Lund¹

¹Department of Systems Biology, Technical University of Denmark, Kgs. Lyngby, Denmark

²Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

³Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

28-3-4: Snake venomics of Micrurus alleni and Micrurus mosquitensis from Costa Rica: two divergent compositional patterns in New World elapids

Julián Fernández¹, Nancy Vargas¹, Davinia Pla², Mahmood Sasa¹, Paola Rey-Suárez³, Libia Sanz², José María Gutiérrez¹, Juan J. Calvete², Bruno Lomonte¹

¹Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

²Instituto de Biomedicina de Valencia, CSIC, Jaume Roig 11, 46010 Valencia, Spain

³Programa de Ofidismo y Escorpionismo, Universidad de Antioquia, Medellín, Colombia

28-3-5: Venomic characterization and bioactivity screening of Vipera anatolica, Vipera darevskii and Montivipera bulgardaghica

Paul M. N. Heiss¹, Daniel Petras¹, Bayram Göçmen², Ayse Nalbantsoy², Mert Karış², Mehmet Z. Yıldız³ and Roderich D. Süßmuth¹

¹ Technische Universität, Berlin, Germany

²Ege University, Bornova Izmir, Turkey

³Adıyaman University, Adıyaman, Turkey

28-3-6: VenomZone: a new website to unravel venom complexity

Florence Jungo¹, Edouard de Castro¹, Lydie Bougueleret¹, Ioannis Xenarios^1,2, Sylvain Poux¹

¹Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland

²Vital-IT Group, SIB Swiss Institute of Bioinformatics, Quartier Sorge – Bâtiment Génopode, 1015, Lausanne, Switzerland

28-3-7: Utilization of neurotoxin-inspired peptide libraries in in-vitro evolution, and its proved pluripotency to target GPCRs, proteases and trophic factors

Tai Kubo^{1, 2}, Mohammed Naimuddin², Seigo Ono², Takatsugu Hirokawa¹

¹Molecular Profiling Research Centre for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan

²Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan

28-3-8: Top-down Venomics: mapping intact proteoforms and protein complexes in king cobra venom

Rafael D Melani^1,2, Luca Fornelli², Owen S Skinner², Gilberto B Domont¹, Philip D Compton², Neil L Kelleher²

¹Proteomic unit, Department of Biochemistry, Chemistry Institute, Universidade Federal do Rio de Janeiro, RJ, Brazil

²Departments of Chemistry and Molecular Biosciences, the Chemistry of Life Processes Institute, and the Proteomics Center of Excellence, Northwestern University, Evanston, IL, United States

28-3-9: Proteomic and transcriptomic investigation of the venom from Australian sea anemones provides insight into venom evolution and ecology

Bruno Madio, Eivind A B Undheim, Glenn F King

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Qld, Australia

28-3-10: VENOMICS project:  Production of two and three-Disulfide-Bridges small Toxins

Grégory Upert, Denis Servent,  Nicolas Gilles, Gilles Mourier

CEA, iBiTecS, Service d’Ingénierie Moléculaire des Protéines, Laboratoire de Toxinologie Moléculaire et Biotechnologies, Gif-sur-Yvette, France

28-3-11: Monoclonal-based antivenomics and biological activities revealing conserved neutralizing epitopes across Elapidae family

Carlos Correa Netto^1,2, Ricardo Teixeira Araújo¹, Marcelo Strauch^1,3, Leonora Brazil-Más¹, Marcos Machado³, Moema Leitão-Araújo⁴, Paulo Melo³, Débora Foguel², Juan Calvete⁵, Russolina Zingali²

¹Instituto Vital Brazil, Niterói, Rio de Janeiro, Brazil

²Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Brazil

³Programa de Farmacologia e Química Medicinal- Universidade Federal do Rio de Janeiro, Brazil

⁴Fundação Zoobotânica do Rio Grande do Sul, Brazil

⁵Instituto de Biomedicina de Valencia, Spain

28-3-12: Bothrops jararaca proteopeptidome: extensive molecular characterization of samples to be assayed by the connectivity map approach

Carolina A Nicolau^1,3, Francisco Gomes-Neto¹, Paulo C Carvalho²,  Jonas Perales¹,  Ana Gisele C Neves-Ferreira¹, Jay  W Fox³, Richard H Valente¹

¹Oswaldo Cruz Foundation, IOC, Laboratory of Toxinology, Rio de Janeiro, Brazil

²Oswaldo Cruz Foundation, ICC, Laboratory for Proteomics and Protein Engineering, Paraná, Brazil

³Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, USA

28-3-13: Snake venomics of the palm-pitvipers Bothriechis bicolor, B. aurifer and B. thalassimus from Guatemala

Davinia Pla¹, Libia Sanz¹, Bruno Lomonte², Mahmood Sasa², Manuel E. Acevedo³, Alicia Pérez¹, Yania Rodriguez¹, Juan J. Calvete¹

¹Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain

²Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

³Escuela de Biologia, Universidad de San Carlos de Guatemala, Guatemala, Guatemala

28-3-14: Diversity of peptide toxins from four Conus venoms revealed by combined cutting-edge technologies of proteomics, transcriptomics and bioinformatics

Michel Degueldre¹; Marion Verdenaud², Garikoitz Legarda³, Rebeca Minambres³, Sheila Zuniga³, Mathieu Leblanc⁴, Nicolas Gilles⁵, Frederic Ducancel⁶; Edwin De Pauw¹; Loic Quinton¹

¹Laboratory of mass spectrometry GIGA-R, Department of Chemistry, University of Liège, Liege, Belgium

²IBiTecS, S/SPI Antibody Eng. For Heath, CEA, Gif-sur-Yvette, France

³Sistemas Genomicos Ltd, Valencia, Spain

⁴VenomeTech, Valbonne, France

⁵IBiTecS, SIMOPRO, CEA, Gif-sur-Yvette, France

⁶IMETI/UMR 1184, CEA, Fontenay-aux-Roses, France

28-3-15: Vipera lebetina venom nucleases

Katrin Trummal¹, Külli Tõnismägi¹, Anu Aaspõllu², Juhan Subbi¹, Jüri Siigur¹, Ene Siigur¹

¹National Institute of Chemical Physics and Biophysics, Tallinn, Estonia

²Institute of Gene Technology, Tallinn University of Technology, Tallinn, Estonia

28-3-16: Adaptive advantages of individual variation of Bothrops atrox venom from snakes collected at different phytogeographical scenarios in Brazilian Amazon

Leijiane F de Sousa¹; José A Portes-Junior¹; Juliana L Bernardoni¹; Carolina A Nicolau⁴; Diana R Amazonas¹; Luciana A F de Sousa¹; Mônica Colombini¹, Rosa H V Mourão²; Hipócrates de M Chalkidis³; Richard H Valente⁴; Ana M.  Moura-da-­Silva¹

¹Laboratório de Imunopatologia, Instituto Butantan, São­­ Paulo, Brasil

²Universidade Federal do Oeste do Pará, Pará, Brasil

³Facudades Integradas do Tapajós, Pará, Brasil

⁴Fundação Oswaldo Cruz, Rio de Janeiro, Brasil

28-3-17: High-Throughput synthesis and cloning of genes encoding venom peptides: developing a platform for the discovery of novel therapeutic molecules

Ana F. Sequeira^1,2, Joana L. A. Brás^1,2, Catarina I.P.D. Guerreiro², Renaud Vincentelli³, Carlos M.G.A. Fontes^1,2

¹CIISA-Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, 1300-477 Lisboa, Portugal

²NZYTech Lda, Estrada do Paço do Lumiar, Campus do Lumiar, Edifício E-R/C, 1649-038 Lisboa, Portugal

³Architecture et Fonction des Macromolécules Biologiques (A.F.M.B), UMR7257 CNRS, Université Aix-Marseille, Case 932, 163 Avenue de Luminy, 13288 Marseille Cedex, France

28-3-18: High Throughput Disulfide Bond Profiling of Crude Snake Venom Using Mass Spectrometry

Sheng-Yu Huang¹, Sung-Fang Chen², Hsuan-Wei Huang^3,4, Wen-Guey Wu³,  Wang-Chou Sung ⁴

¹Mithra Biotechnology Inc, New Taipei City, Taiwan

²Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan

³Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan

⁴National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli County, Taiwan

28-3-19: Venomics of Hydrophis schistosus, the beaked sea snake: a simple toxin arsenal cross-neutralised by two heterologous antivenoms

Choo Hock Tan¹, Kae Yi Tan², Shin Yee Fung², Nget Hong Tan²

¹Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

²Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

28-3-20: Geographical variations of Naja kaouthia (monocled cobra) venom from Southeast Asia: a venomic and functional study

Kae Yi Tan, Choo Hock Tan, Shin Yee Fung, Nget Hong Tan

¹Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

²Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

28-3-21: Mechanisms of production and secretion of toxins by secretory cells from Bothrops jararaca venom gland in culture: a secretome study

Luciana G. Viana¹, Richard H. Valente², Jonas Perales², Norma Yamanouye¹

¹Lab. Pharmacology, Instituto Butantan, São Paulo, SP, Brazil

²Lab. Toxinology, Instituto Oswaldo Cruz – Fiocruz, Rio de Janeiro, RJ, Brazil

Session 4: Genomics and transcriptomics – 28th September

28-4-1: An overview on the development of Bothrops jararaca genome project

Diego D Almeida¹, George WC Epamino², Milton Y Nishiyama-Jr ¹, Setubal JC², Azevedo ILMJ¹

¹Laboratório Especial de Toxinologia Aplicada/Centro de Toxinas, Resposta-Imune e Sinalização Celular (CeTICS), Instituto Butantan, São Paulo, Brazil

²Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil

28-4-2: Population genomics of Bothrops atrox in the West of Para State, Brazil: Analyses Using RADseq Genetic Markers

Diana R Amazonas¹, Michael G Sovic², Hipócrates M Chalkidis³, Rosa Helena Veras Mourão⁴, Alfredo P Santos-Jr⁴, Melissa G Martinez⁵, Plínio B Camargo⁵, Ana M Moura-da-Silva¹, H Lisle Gibbs²

¹Instituto Butantan, Laboratório de Imunopatologia, São Paulo-SP, Brazil

²Ohio State University, Department of Evolution, Ecology and Organismal Biology, Columbus-OH, USA

³Faculdades Integradas do Tapajós, Laboratório de Pesquisas Zoológicas, Santarém-PA, Brazil

⁴Universidade Federal do Oeste do Pará, Santarém-PA, Brazil

⁵Centro de Energia Nuclear na Agricultura, Universidade de São Paulo, Piracicaba-SP, Brazil

28-4-3: Transcriptome analysis of venomous glands of male and female scorpions of the species Centruroides limpidus

Jimena Cid-Uribe, Ernesto Ortiz, MariaT Romero-Gutiérrez and Lourival D. Possani

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, UNAM, Av. Universidad 2001, Cuernavaca, Morelos 62210, México

28-4-4: Testing the hypothesis that miRNAs modulate ontogenetic changes in the venom of Crotalus simus

Jordi Durban¹, Edgar Neri Castro^2,3, Alejandro Alagón², Juan J. Calvete¹

¹Instituto de Biomedicina de Valencia (CSIC), Jaume Roig 11, 46010 València, Spain

²Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México

³Centro de Ciencias Genómicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México

28-4-5: Genes Involved in Blood Coagulation: Exploring Salivary Complexes from Haementeria vizottoi leeches through Transcriptomic and Phylogenetic Studies

Fernanda Faria¹, Adriane MXP Amorim¹, Ursula C Oliveira², Inácio LM Junqueira-de-Azevedo², Kerly FM Pasqualoto¹, Ana M Chudzinski-Tavassi^{1, 3}

¹Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, SP, Brazil

²Laboratório Especial de Toxinologia Aplicada, CeTICS, Instituto Butantan, São Paulo, SP, Brazil

³Departamento de Biologia Molecular, Unifesp, São Paulo, SP, Brazil

28-4-6: In silico identification of protein disulfide isomerase genes in the de novo assembled transcriptomes of four different species of the genus Conus

Andrea Figueroa-Montiel¹, Marco A Ramos-Ibarra², Rosa E Mares-Alejandre², Salvador Dueñas-Espinoza¹, Genaro Pimienta-Rosales¹ and Alexei F Licea-Navarro¹

¹ Department of Biomedical Innovation, Center for Scientific Research and Highr Education at Ensenada, Ensenada, Baja California, Mexico.

² Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana, Baja California, Mexico

28-4-7: Deciphering the venom of the rear fanged snake Phalotris mertensi by integrative multiomics and biochemical approaches

Pollyanna F Campos¹, Débora A Silva¹, André Zelanis², Adriana Franco Paes Leme³, Solange M Serrano¹, Inácio L M Junqueira-de-Azevedo¹

¹Laboratório Especial de Toxinologia Aplicada, Instituto Butantan, Brazil

²Departamento de Ciência de Tecnologia, Universidade Federal de São Paulo, São José dos Campos, Brazil

³Brazilian Laboratory of Biosciences, Campinas, Brazil

28-4-8: Comparative transcriptomes and proteomes from medically important scorpions from the genus Tityus

Ursula C de Oliveira¹, Milton Y Nishiyama Junior¹, Denise M Candido², Norma Yamanouye³ , Valquiria AC Dorce³, Inacio LM Junqueira-de-Azevedo¹

¹Laboratório Especial de Toxinologia Aplicada, CeTICS, Instituto Butantan, Brazil

 ²Laboratório de Artrópodes, Instituto Butantan, Brazil

³Laboratório de Farmacologia, Instituto Butantan, Brazil

28-4-9: Insights on the transcriptomic analysis of the venomous gland of the scorpion Thorellius atrox

María T. Romero-Gutiérrez¹, Verónica Quintero-Hernández¹, Alejandro Sanchez-Flores², Ernesto Ortiz¹, Lourival D Possani¹

¹Departamento de Medicina Molecular y Bioprocesos

²Unidad Universitaria de Secuenciación Masiva y Bioinformática; Instituto de Biotecnología, UNAM, Av. Universidad 2001, Cuernavaca, Morelos, México

28-4-10: Genomic organization of Echis ocellatus PI- and PII-SVMP  genes

Libia Sanz and Juan J. Calvete

Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC,     Valencia, Spain

28-4-11: Transcriptomic analysis of the venom gland of the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs)

Montamas Suntravat¹, Néstor L Uzcategui², Chairat Atphaisit¹, Thomas J Helmke¹, Sara E Lucena¹, Alexis Rodriguez-Acosta², Elda E Sanchez¹

¹National Natural Toxins Research Center, Texas A&M University-Kingsville, Kingsville, USA

²Laboratorio de Inmunoquímica y Ultraestructura, Instituto Anatómico de la Universidad Central de Venezuela, Caracas, Venezuela

Session 5:  Ion channel toxins – 29th September

29-5-1: Parallel evolution of sodium channel activation inhibitors in Araneomorphae and Mygalomorphae?

Antonina A. Berkut^1,2, Steve Peigneur³, Mikhail Yu. Myshkin^1,2, Alexander S. Paramonov², Zakhar O. Shenkarev², Jan Tytgat³, Eugene V. Grishin², Alexander A. Vassilevski²

¹Moscow Institute of Physics and Technology, Moscow, Russia

²Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

³University of Leuven, Leuven, Belgium

29-5-2: Identification of Kir4.1 channel as a prospective target by the bee venom peptide tertiapin through virtual screening and computational docking

Craig A. Doupnik

Department of Molecular Pharmacology & Physiology, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

29-5-3: Modulation of Kv4. channels by pore blockers of the scorpion a-Ktx 15 subfamily

Marie-France Martin-Eauclaire, Pierre E. Bougis

Aix Marseille University, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille UMR7286, 13344, Marseille, France

29-5-4: Spider toxin distinguish between mammalian and insect sodium channels

Ana Luiza B. Paiva^1,3, Alessandra  Matavel¹, Steven Peigneur², Jan Tytgat², Marcelo R. V. Diniz¹, Maria Elena de Lima³

¹Research and Development Division, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil

²Toxicology and Pharmacology, University of Leuven (K.U. Leuven), Leuven, Belgium

²Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil

29-5-5-: Philanthotoxin analogues are potent and subtype selective inhibitors of nicotinic acetylcholine receptors

Hamid S Kachel¹, Henrik Franzyk², Denis B Tikhonov³, Ian R Mellor¹

¹School of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

²Department of Molecular Drug Research, University of Copenhagen, Denmark³Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

29-5-6: Activity-guided purification and electrophysiological characterization of a novel K_v10.1 inhibitor from the sea anemone Anthopleura elegantissima

Lien Moreels¹, Steve Peigneur¹, Diogo T Galan¹, Sandy Vandoninck ², Lászlo Béress³, Etienne Waelkens², Jan Tytgat¹

¹Toxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg, O&N2, Herestraat 49, PO Box 922, 3000 Leuven, Belgium

²Laboratory of Protein Phosphorylation and Proteomics, University of Leuven (KU Leuven), Campus Gasthuisberg, O&N1, Herestraat 49, PO Box 901, 3000 Leuven, Belgium

³Immunology and Rheumatology, Section of Peptide Chemistry, Hannover Medical School (MHH), 30625 Hannover, Germany

29-5-7: Centipede venom components and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

Neville M Ngum, David P Richards, Ian R Mellor, Ian R Duce

School of Life Sciences, University of Nottingham

29-5-8: Expression of disulfide-rich toxins in E.coli: co-expressed chaperone enzymes produce correct disulfide reticulation and folding of a scorpion β-toxin

Andrias O O’Reilly¹, Ambrose R Cole², Jose L S Lopes³, Angelika Lampert⁴ and B A Wallace²

¹School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, United Kingdom

²Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, United Kingdom.

³Department of Applied Physics, University of São Paulo, Estado de Sao Paulo, Brazil

⁴Institute of Physiology, RWTH Aachen University Hospital, 52074 Aachen, Germany

29-5-9: Investigating the inhibition of nicotinic acetylcholine receptors by ladybird alkaloids

Rohit N Patel¹, David P Richards¹, John A Pickett², Mike A Birkett², Ian R Duce¹, Ian R Mellor¹

¹School of Life Sciences, Life Sciences Building, University of Nottingham, University Park, Nottingham, NG7 2RD

²Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ

29-5-10: Mapping the residues that mediate interaction of the spider-venom peptide μ-TRTX-Hd1a with the analgesic target Na_V1.7

Jennifer J Smith and Glenn F King

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia

29-5-11: Disturbance of Intracellular Calcium Homeostasis and Cardiomyocyte Function by a protein in fraction six of Naja kaouthia Venom

Kittipong Tachampa¹, Orawan Khow², Narumon Pakmanee², Christian Barrere³, Mattia Di Francesco³, Joel Nargeot³ , Narongsak Chaiyabutr², Visith Sitprija²

¹Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand

²Queen Saovabha Memorial Institute, the Thai Red Cross Society, Bangkok, Thailand

³Institut de Genomique Fonctionnelle, Universites de Montpellier, Montpellier, France

29-5-12: Chemical synthesis of mambalgin-1 toxin and binding analysis to Acid Sensing Ion Channels using two-Photon Fluorescence Microscopy

Changlin Tian^1,2, Ming Wen¹, Xiqoqi Guo^1,2, Yao He¹, Longhua Zhang¹, Ying Xiong¹

¹School of Life Sciences, University of Science and Technology of China, Hefei, P. R. China

²High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, P. R. China

Session 6: Conotoxins and other pain-inducing toxins – 29th September

29-6-1: Natural compounds as inhibitors of acid-sensing channel ASIC3

Yaroslav A Andreev, Dmitry I Osmakov, Sergey A Kozlov, Eugene V Grishin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Miklukho-Maklaya 16/10, Moscow, Russia

29-6-2: Member of gamma-conotoxin family isolated from Conus princeps displays novel molecular target

Johanna Bernáldez¹, Samanta Jimenez¹, Luis J González², Jesús Noda², Enrique Soto³, Emilio Salceda³, Daniela Chávez¹, Manuel Aguilar⁴ and Alexei Licea¹

¹Department of Biomedical Innovation, Center of Scientific Research and Higher Education at Ensenada, Baja California, México.

²Department of Proteomics, Mass Spectrometry Laboratory, Center of Genetic Engineering and Biotechnology, La Habana, Cuba.

³Institute of Physiology, Meritorious Autonomous University of Puebla, Puebla, México.

⁴Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, México

29-6-3: Structures, functions of several novel conotoxins from Conus snails in South China Sea

Qiuyun Dai¹, Zhuguo Liu¹, Shuo Wang¹,  Rong Ding¹, Kejun Zhang¹,Ting Sun¹,  Jie Hu¹,  Na Liu¹, Cong zhao², Xuesong Wang², Weihong Du^2,*, Tianpeng Du³, Lin Jiang³

¹Beijing Institute of Biotechnology, the Academy of Military Medical Sciences, Beijing 100071, People’s Republic of China

²Department of Chemistry, Renmin University of China, Beijing, 100872, China

³Wuhan Institute of Physics and Methematics , Chinese Academy of Sciences, Wuhang, 430071,China

29-6-4: Pharmacological exploration with animal toxins of the role of Acid-Sensing Ion Channels in pain pathways

Sylvie Diochot¹, Anne Baron¹, Emmanuel Deval¹, Miguel Salinas¹, Dominique Douguet¹, Valérie Friend¹, Abdelkrim. Alloui², Alain Eschalier², Michel Lazdunski¹ & Eric Lingueglia¹

¹Institut de Pharmacologie Moléculaire et Cellulaire, LabEx Ion Channel Science and Therapeutics, CNRS/Université de Nice Sophia Antipolis UMR7275, 06560 Valbonne, France

²Neuro-Dol,, Inserm U1107, Clermont Université, Université d’Auvergne, F-63000 Clermont-Ferrand, France

29-6-5: Conus australis, an as yet unexplored Conus sp. with novel conotoxins

Eline K.M. Lebbe¹, Steve Peigneur¹, Mohitosh Maiti² Bea G. Mille¹, Prabha Devi³, Samuthirapandian Ravichandran⁴, Eveline Lescrinier², Lisette D’Souza³, Piet Herdewijn² and Jan Tytgat¹

¹Toxicology and Pharmacology, KU Leuven, O&N2-P.O. Box 922, Herestraat 49, 3000 Leuven, Belgium

²Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Dept. of Pharmaceutical & Pharmacological Sciences, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium

³CSIR-National Institute of oceanography, Dona Paula, 403 004 Goa, India

⁴Center of Advanced Study in Marine Biology, Annamalai University, Parangipettai, 608 502 Tamil Nadu, India

29-6-6: PnPP-19, a synthetic peptide representing an eptitope of the toxin PnTx2-6 from the spider Phoneutria nigriventer, shows antinociceptive effect

Ana Cristina Nogueira Freitas, Igor Dimitri Gama Duarte, Daniela Pacheco and Maria Elena de Lima

Lab Venenos e Toxinas Animais, Depto.Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG. Belo Horizonte, MG. Brazil

29-6-7: ASIC3 channel inhibitors produced by a mutagenesis of inactive homolog of peptide Ugr9-1 from the venom of sea anemone Urticina grebelnyi

Dmitry I Osmakov, Sergei G Koshelev, Yaroslav A Andreev, Sergei A Kozlov, Eugene V Grishin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

29-6-8: Complementary molecular dynamics and mutagenesis approach reveals critical interactions for PcTx1 inhibition of the therapeutic target ASIC1a

Natalie J Saez¹, Evelyne Deplazes^1,2, Ben Cristofori-Armstrong¹, Irène R Chassagnon¹, Xiaozhen Lin⁴, Mehdi Mobli³, Alan E. Mark², Lachlan D Rash¹ and Glenn F King^1,2

¹Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia

²School of Chemistry & Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, Australia

³Centre for Advanced Imaging, The University of Queensland, St. Lucia, QLD 4072, Australia

⁴Current address: Beijing Genomics Institute, Yantian District, Shenzhen, 518083, China

Session  7:  Snake venom metalloproteinases, phospholipases and other toxins mediating inflammation – 26th September

26-7-1: Purification and characterization of two platelet-aggregation inhibitors, named angustatin and H-toxin TA₂, from the venom of Dendroaspis angusticeps

Oyama Etsuko

Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

26-7-2: Biophysical studies suggest a new arrangement of crotoxin complex and provide insights into CB oligomerization

Carlos A. H. Fernandes¹, Walter L. G. Cavalcante¹, Thiago. R. Dreyer¹, Roberto M. Fernandez¹, Wallance Moreira Pazin², Renata Naporano Bicev³ Cristiano L. P. Oliveira³, Marcos R. M. Fontes¹

¹Departament of Physics and Biophysics, Institute of Biosciences, UNESP, Botucatu, Brazil

²Departament of Physics and Mathematics, FFCLRP, USP, Ribeirão Preto, Brazil

³Departament of Experimental Physics, Institute of Physics, USP, São Paulo, Brazil

26-7-3: Structural and evolutionary insights into endogenous alpha-phospholipase A₂ inhibitors of Latin American pit vipers

Maria I Estevão-Costa¹, Carlos AH Fernandes², Maurício A Mudadu¹, Glória R Franco³, Marcos RM Fontes ², Consuelo L Fortes-Dias ¹

¹ Research and Development Center, Fundação Ezequiel Dias (FUNED), Belo Horizonte, MG, Brazil

²Departament of Physics and Biophysics, Institute of Biociences, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil .

³Departament of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG),  Belo Horizonte, MG, Brazil

26-7-4: Snake venom phospholipases A₂ (MT-3 and BthTx-2) induce vascular smooth muscle foam cell formation dependent on lipid metabolism factors

Karina C Giannotti¹, Mariana N Viana¹, Elbio Leiguez¹,Thaís L  Araújo², Francisco Laurindo²,Renata H A Hernandez¹, José Maria Gutiérrez³, Bruno Lomonte³, Suely Sampaio⁴, Catarina Teixeira¹

¹Laboratório de Farmacologia, Instituto Butantan, São Paulo/SP, Brazil

²Laboratório de Biologia Vascular, Instituto do Coração (Incor), São Paulo/SP, Brazil

³Instituto Clodomiro Picado, Universidad de Costa Rica, Costa Rica,

⁴Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo (USP), São Paulo/SP, Brazil

26-7-5: Proteolytic degradation of muscle basement membrane by SVMPs: pathophysiologic implications in muscle necrosis

Alexandra Rucavado¹, Andrea Ulloa¹,  Stephany Chaves¹,  Teresa Escalante¹, Eladio Flores Sánchez²,  José María Gutiérrez¹

¹Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

²Centro de Pesquisa e Desenvolvimento, Fundaçao Ezequiel Dı́as, Belo Horizonte, Minas Gerais, Brazil

26-7-6: A new neuromuscular active fraction from Bothrops fonsecai venom

Raphael Schezaro-Ramos¹, Priscila Randazzo-Moura², Mariana Leite Matascia³, José Carlos Cogo⁴, Léa Rodrigues-Simioni¹

¹Neuromuscular Junction Lab, Dept of Pharmacology, State University of Campinas – UNICAMP, Campinas/SP, Brazil

²Pharmacology Laboratory, Pontifical Catholic University of Sao Paulo – PUC-SP, Sorocaba/SP, Brazil

³Biochemical Pharmacology Lab, Dept of Pharmacology, State University of Campinas – UNICAMP, Campinas/SP, Brazil

⁴Center of Naturel Studies, University of Paraíba Valley – UNIVAP, São José dos Campos/SP, Brazil

26-7-7: Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII-SVMP

Luciana A F Sousa^1,2, Diana R Amazonas², Leijiane F Sousa², Sávio S Sant’Anna³, Milton Y Nishiyama-Jr⁴, Solange M T Serrano⁴, Inácio L M Junqueira-de-Azevedo⁴, Hipócrates M Chalkidis⁵, Ana M Moura-da-Silva², Rosa H V Mourão¹

¹Programa de Pós-Graduação em Recursos Naturais da Amazônia, Laboratório de Bioprospecção e Biologia Experimental, Universidade Federal do Oeste do Pará – UFOPA, Rua Vera Paz, s/n, 68035-110 Santarém, PA, Brazil

²Laboratório de Imunopatologia, ³Laboratório de Herpetologia; ⁴Laboratório Especial de Toxinologia Aplicada, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, SP, Brazil

⁵Faculdades Integradas do Tapajós – FIT, Rua Rosa Vermelha, 335, 68010-200 Santarém, PA, Brazil

26-7-8: Phospholipase A₂ subunit of crotoxin inhibits expression of endothelial cell adhesion molecules involved in leukocyte diapedesis during inflammation

Marcio H Matsubara¹, Elbio Leiguez¹, Eduardo K Tamura³, Consuelo L Dias-Fortes², Catarina Teixeira¹

¹Laboratório de Farmacologia, Instituto Butantan, Sao Paulo,SP, Brazil

²Laboratório de Biologia Molecular e Bioinformática, Fundação Ezequiel Dias, Belo Horizonte, MG, Brazil

³Laboratório de Cronofarmacologia, Instituto de Biociências, Universidade de São Paulo, Sao Paulo,SP, Brazil

26-7-9: Direct Cytotoxic activity of Iranian Agkistrodon Halys Crude Venom on Endothelial Cells

Maryam Kakanj¹, Hossein Vatanpour ¹, Mahmoud Ghazi-Khansari ², Abbas Zare Mirakabadi³, Hadie Rabiei ³, Saba Vatanpour⁴ and Akram Aboutorabi ¹

¹Department of Toxicology, School of Pharmacy, Shahid-Beheshti University of Medical Sciences, Tehran, Iran

²Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

³Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Karaj, Iran

⁴Department of Sciences University of British Columbia, BC, Canada

29-7-10: Effect of serum creatine kinase in rabbits as affected by myotoxin phospholipase A₂ partially purified from Naja nigricollis venom

Kurfi, B.G.¹, Babagana, K.², Abdussamad, A.M.² and Tukur, Z.²

¹Department of Biochemistry, Faculty of Biomedical Sciences, Bayero University, Kano, Nigeria

²Department of Animal Science, Faculty of Agriculture, Bayero University, Kano, Nigeria

³Department of Biological Sciences, Faculty of Science, Bayero University, Kano, Nigeria

29-7-11: Snake venom metalloproteinases inhibit angiogenesis in a three-dimensional in vitro assay

Anrabel Araya,  Stephanie Chaves, Alexandra Rucavado, José M Gutiérrez, Teresa Escalante

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

Session 8: Antivenom-1: Innovation and commercialisation – 26th September

26-8-1: Economic analysis of the underlying causes for the snake antivenom market failure in sub-Saharan Africa: looking beyond science for explanations

Alexandra Bak Jakobsen

Department of Economics and Business Administration, Copenhagen Business School, Denmark

26-8-2: Development of equine origin lyophilized polyvalent Snake Venom Antiserum against 4 Bitis, 3 Echis, 3 Naja and 4 Dendroaspis species for Africa

Milind V Khadilkar, Anil S Yadav , Dilip G Kulkarni, Sandeep S Patil and Shyam B Dhawan

Premium Serums & Vaccines Pvt.Ltd., At & Post Narayangaon, Tal-Junnar,  Dist-Pune Pin 410504, (Maharashtra), India

26-8-3: The future of antivenoms: Oligoclonal mixtures of recombinant, human(ized) antibodies

Andreas H Laustsen

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

Session 9: Antivenom-2: Pre-clinical and clinical assessment – 26th September

26-9-1: High incidence of anaphylactic shock to horse-derived F(ab’)₂ antivenom in 99 snakebite patients treated at Savannakhet provincial hospital, Lao PDR

Inthanomchanh Vongphoumy^1,2 and Joerg Blessmann^2,3

¹Provincial Health Department Savannakhet, Lao PDR, ² Provincial Hospital Savannakhet, Lao PDR, ³Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

26-9-2: Size-exclusion chromatography on venom: antivenom binding analysis: a new perspective for F(ab’)₂ antibody fragments study

Rita C O Collaço¹, Priscila Randazzo-Moura², José C Cogo³,  Charles G Sanny⁴, Léa Rodrigues-Simioni¹

¹Departamento de farmacologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil

²Pontifical Catholic University of Sao Paulo, Sorocaba, SP, Brazil

³Serpentarium of Center for Nature Studies, Vale do Paraíba University, Sao Jose dos Campos, SP, Brazil

⁴Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA

26-9-3: Retrospective review of snakebites treated with new Snake venom Antiserum in rural Maharashtra, India

Shyam B Dhawan and Milind V Khadilkar

Premium Serums & Vaccines Pvt. Ltd. (PSVPL), At & Post Narayangaon, Tal-Junnar,  Dist-Pune Pin 410504 , (Maharashtra), India

26-9-4: The Diamond Hour

Trevor S. Cook¹, Gus A. Gross^1,2, Karen Avgush¹, Vishal Kwatra¹, Ikram Hassan¹

¹Palacios Community Medical Center, Palacios, Texas, USA

²Matagorda Regional Medical Center, Bay City, Texas, USA

26-9-5: A study to estimate the prevalence of adverse reactions to anti-snake venom therapy in a tertiary care centre in South India

Ajith Venugopalan¹, Ajith Kumar¹, Sreekrishnan¹, Sabarish Balachandran ¹, Rituna Medayil¹, Bharath Prasad¹, Naveen Mohan¹, Arun Kumar¹, Krupanidhi Karunanithi¹, Sundaram KR², Renjitha Bhaskaran², Priya R Menon¹,  Gireesh Kumar ¹, Vijay V Pillay³

¹Department of Emergency Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India

²Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India

³Poison Control Centre, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India India

29-9-6: Neutralization of Crotalus atrox venom by heterologous antivenom in experimental model

Adolfo de Roodt ^1,2,3, Néstor Lago ³, Laura Lanari ⁴, Vanessa Costa de Oliveira  ^2,4, Carlos Damin ², Ernesto de Titto ¹

¹Dirección Nacional de Determinantes de la Salud e Investigación, Ministerio de Salud, Argentina.

²Cátedra de Toxicología, Facultad de Medicina, Universidad de Buenos Aires.

³Centro de Patología Experimental y Aplicada, Facultad de Medicina, Universidad de Buenos Aires, Argentina

⁴INPB-ANLIS “Dr. Carlos G. Malbrán”, Ministerio de Salud, Argentina and Dirección Nacional de Epidemiología, Ministerio de Salud, Argentina

29-9-7: The immunochemical reactivity and the neutralizing capacity of Crotalus durissus terrificus antivenom

Federico Baudou ¹, Adolfo de Roodt ^2,3, Laura Lanari ¹, Rodrigo Laskowicz ¹, Ernesto de Titto ², Carlos Damín ³

¹INPB-ANLIS “Dr. Carlos G. Malbrán”, Ministerio de Salud, Argentina

²Dirección Nacional de Determinantes de la Salud e Investigación, Ministerio de Salud, Argentina

³Cátedra de Toxicología, Facultad de Medicina, Universidad de Buenos Aires, Argentina

29-9-8: Preclinical efficacy of four antivenoms distributed in Western sub-Saharan Africa against Echis ocellatus venom from three countries

Laura Sánchez¹, Davinia Pla²,  María Herrera¹, Juan J Calvete²,  José María Gutiérrez¹

¹Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

²Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain

Electrophysiological analysis of anti-venom efficacy against North African scorpions

Rita Restano-Cassulini¹, Jorge F Paniagua-Solís², Walter García² and Lourival D Possani¹

¹Instituto de Biotecnologia, National Autonomous University of México, Av. Univeresidad, 2001, Cuernavaca, Morelos 62210, Mexico

²Instituto Bioclón S.A. de C.V., Calz. de Tlalpan 4687, Del. Tlalpan, 14050, Mexico, D.F., MEXICO

Session 10: Clinical-1: Snake-bites – 28th September

28-10-1: Snakebites in rural northern Bihar, India – A one year, prospective study on snakebite epidemiology and risk factors for bad outcomes

Lois Armstrong¹, Taka Longkumer¹, Vishal Santra², Philip Finny¹

¹Duncan Hospital, Raxaul, East Champaran District, Bihar, India.

²Simultala Conservationists, Nalikul, Hooghly, West Bengal, India.

28-10-2: Microorganisms isolated from blisters and abscess secretions in patients bitten by Bothrops snakes

Hui Wen Fan, Ceila Maria Sant’Ana Malaque, Christina Gallafrio Novaes, Márcia Regina Franzolini, Kathleen Grego, Osvaldo Augusto Sant’Anna

Instituto Butantan, Av. Vital Brasil, 1500, Butantã, 05503-900, São Paulo/SP, Brazil

28-10-3: Severe local pain after Hump nosed viper bite alleviation with new methods: Audit in Base Hospital Elpitiya Sri Lanka

Kasun Fernando¹, S.P.K. Wathudura¹, S. A. M. Kularatne²

¹Base Hospital, Elpitiya Sri Lanka

²University of Peradeniya, Peradeniya Sri Lanka

28-10-4: Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species:  Differential Markers for Venom Mechanisms of Action and Potential for Personalized Therapeutic Intervention

Jessica K. A. Macêdo^1,2, John D. Shannon¹, Joseph K. Joseph³, Jaideep Menon⁴, Teresa Escalante⁵, Alexandra Rucavado⁵, José M. Gutiérrez⁵, Jay W. Fox¹

¹University of Virginia School of Medicine, Charlottesville, VA 22908, USA

²Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, Brasilia/DF, Brazil

³Little Flower Hospital, Angamaly, India

⁴Sree Naryana Institute of Medical Science, Kerala, India

⁵Instituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San José, Costa Rica

28-10-5: Rattlesnakes (Crotalus durissus) bites in Santarém/Pará (Brazilian Amazonia)

Pasesa P.Q.Torrez¹, Renato Said¹, Mariana M.M. Quiroga¹ Marcelo R. Duarte² Luciana P. Campos³, Emmanuel Burdmann⁴, Vidal H. Júnior⁵ Francisco O. S. França^1,6

¹Advanced Tropical Medicine Center, Santarém, PA/Department and Division of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

²Laboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil

³Municipal Hospital of São Jose dos Campos, São Paulo, SP, Brazil

⁴LIM 12, Division of Nephrology, University of São Paulo Medical School, São Paulo, SP, Brazil

⁵Departament of Dermatology and Radiotherapy, School of Medicine, Paulista State University (UNESP – Botucatu Campus)

⁶Department and Division of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

28-10-6: Forest pit viper (Bothiopsis bilineata bilineata) bite in the Brasilian Amazon with acute kidney injury and persistent thrombocytopenia

Pasesa P.Q.Torrez ¹, Renato Said¹, Mariana M.M. Quiroga¹, Marcelo R. Duarte², Francisco O. S. França^1,3

¹Advanced Tropical Medicine Center, Santarém, PA/Department and Division of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

²Laboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil

³Department and Division of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

28-10-7: From Venome to Syndrome: Using Mass Spectrometry to Understand the Correspondence of Rattlesnake Venom Composition and Clinical Symptoms of Snakebite   

William K Hayes¹, Aaron G Corbit¹, Sean P Bush², Eric C K Gren¹, Allen M Cooper¹, Chip Cochran¹, Gerad A Fox¹, Carl E Person¹, Wayne Kelln¹, Ben D Gardner¹

¹Loma Linda University School of Medicine, Loma Linda, CA, USA

²Brody School of Medicine, East Carolina University, Greenville, NC, USA

28-10-8: Classic “Depo-effect” of Crotalus Venom

Gus A Gross^1,2, Don Merrill¹, William Crowley², Katherine Lee¹, Katie Gilbert¹, Trevor S Cook¹, Christopher S Hall²

¹Palacios Community Medical Center, Palacios, Texas, USA

²Matagorda Regional Medical Center, Bay City, Texas, USA

28-10-9: “Tip of The Iceberg”

Don Merrill¹, Trevor S Cook¹, Gus A. Gross^1,2, Katherine Lee¹, Elizabeth Fun¹, Christopher Hall²

¹Palacios Community Medical Center, Palacios, Texas, USA

²Matagorda Regional Medical Center, Bay City, Texas, USA

28-10-10: Our Country’s Coral Conundrum

Trevor S. Cook¹, Gus A. Gross^1,2, Michael J. Gross¹, Katherine Lee¹, William Crowley¹ , Leigh Ann Roemer¹

¹Palacios Community Medical Center, Palacios, Texas, USA

²Matagorda Regional Medical Center, Bay City, Texas, USA

28-10-11: Venous Thrombosis Following Rattlesnake Envenomation

Nicholas B. Hurst^1,2, Stephen R. Karpen^1,2, Dan B. Brillhart³, Robert NE. French^1,2, Keith J. Boesen^1,2, Farshad M. Shirazi^1,2

¹Arizona Poison and Drug Information Center, Tucson, Arizona, United States

²Center for Toxicology Pharmacology Education and Research, Phoenix, Arizona, United States³Carl R. Darnall Army Medical Center, Fort Hood, Texas, United States

28-10-12: Six interesting cases of snake bite

Joseph K Joseph¹, Jaideep C Menon², Manoj P Jose³, Pradip P Kendre⁴ and Tarun Sebastain Joseph⁵

¹Senior Consultant Physician And Nephrologist, Little Flower Hospital And Research Centre, Angamaly, Kochi, Kerala, India

²Senior Cardiologist, MAGJ Hospital, Mookkannoor, Kochi, Kerala, India

³Senior consultant physician Little Flower Hospital And Research Centre, Angamaly, Kochi, Kerala, India

⁴Senior Resident , Little Flower Hospital And Research Centre Angamaly, Kochi, Kerala, India

⁵Senior Resident, St Johns Medical College Bangalore, India

28-10-13: A rapid, sensitive, and specific lateral-flow immunochromatographic device to detect most Asian Naja snake venom

Jing-Hua Lin^1,2, Jiunn-Wang Liao¹, Dung-Zong Hung²

1 Graduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung, Taiwan

2 Graduate Institute of Clinical Medcial Science, China Medical University, Taichung, Taiwan

28-10-14: A retrospective study of Red-necked Keelback envenomation at Cho Ray Hospital, Ho Chi Minh City, Viet Nam

Nguyen Thi Thuy Ngan¹, Tran Quang Binh¹, Hoang Lan Phuong¹, Jeremy N Day²

¹Department of Tropical diseases, Cho Ray hospital, Ho Chi Minh city, Vietnam;

²CNS Infections Research Group, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam

³Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom

28-10-15: Registration and location of Bitis Gabonica in Angola

Paula R Oliveira¹, Marisa Rocha², Sávio Sant’Anna², Arnaldo G Castro³, Iris A Betancourt¹

¹Faculty of Medicine, University Lueji A’Nkonde, Malanje, Angola

²Butantan Institute, São Paulo, Brazil

³Research and Information for Drug and Toxicology Center, Malanje, Angola

28-10-16: Medically relevant venomous snakes in Nepal

Deb P Pandey^1,2, Sanjib K. Sharma³, Chhabilal T Magar⁴, Chandra M Sharma⁵, Dietrich Mebs⁶, Gunther Köhler²

¹Department of Herpetology, Senckenberg Research Institute and Natural History Museum, Frankfurt am Main, Germany,

²Biodiversity and Climate Research Centre (BiK-F), Frankfurt am Main, Germany,

³B.P.K. Institute of Health Sciences, Dharan, Nepal

⁴District Hospital, Sindhuli, Nepal

⁵Bajra Dal Battalion Snake Bite Treatment Centre, Tribeni, Nawalparasi, Nepal

⁶Institut für Rechtsmedizin, Goethe University, Frankfurt am Main, Germany

28-10-17: A season of snakebite envenomation: presentation patterns, timing of care, anti-venom use, and case fatality from a hospital of southcentral Nepal

Deb P Pandey¹, Rais Vohra², Philip Stalcup², Bhola R. Shrestha³

¹Department of Zoology, Birendra Multiple Campus, Tribhuvan University, Bharatpur, Chitwan, Nepal (while collecting data); Department of Herpetology, Senckenberg Research Institute and Natural History Museum, Senckenberganlage 25, 60325, Frankfurt am Main, Germany

²UCSF-Fresno Medical Center, Fresno, California, USA

³Bharatpur Hospital, Bharatpur, Chitwan (while collecting data), Midwestern Regional Hospital, Surkhet, Nepal

28-10-18: 0% Mortality & 0% Renal failure in Russell’s Viper Bite patients in Rural set up

Pallavi Raut

Vighnahar Nursing Home Narayangaon, Tal Junnar pune Mah, India

Session 11:  Clinical 2: Arthropod bites and stings – 28th September

28-11-1: “VAPAGuide – The free access Emergency Guide to Venomous and Poisonous Animals”

Mauro Bodio¹ and Thomas Junghanss²

¹Swiss Tropical & Public Health Institute, Basle, Switzerland

²Section Clinical Tropical Medicine, University Hospital, Heidelberg, Germany

28-11-2: Acute cerebellar dysfunction with neuromuscular manifestations after scorpionism presumably caused by Tityus obscurus in Santarém, Pará/Brazil

Pasesa P.Q.Torrez¹, Mariana M.M. Quiroga¹, Paulo A.M. Abati¹, Melissa Mascheretti¹, Walter S. Costa², Luciana P. Campos³, Francisco O. S. França^1,4

¹Advanced Tropical Medicine Center, Santarém, Pará of the Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

²9^o Regional Center of Health Department of Pará

³Municipal Hospital of São Jose dos Campos, São Paulo, SP, Brazil

^1,4Department of Infectious and Parasitic  Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

28-11-3: Venom Allergy – Lessons from Auditing 30+ years of Fatalities in Australia

Forbes McGain^1,2 and Kenneth D Winkel²

¹Department of Anaesthetics and Intensive Care, Western Health, Melbourne, Victoria, Australia

²Australian Venom Research Unit (AVRU), Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia

29-11-4: Mortality by venomous animals in Argentina: Arachnids and Hymenoptera are responsible of the highest mortality

Adolfo de Roodt ^1,2, Laura Lanari ³, Susana García ¹, Vanessa Costa de Oliveira  ^2,4, Natalia Casas ⁴, Carlos Damin ², Ernesto de Titto ¹

¹Dirección Nacional de Determinantes de la Salud e Investigación, Ministerio de Salud, Argentina

²Cátedra de Toxicología, Facultad de Medicina, Universidad de Buenos Aires

³INPB-ANLIS “Dr. Carlos G. Malbrán”, Ministerio de Salud, Argentina

⁴Dirección Nacional de Epidemiología, Ministerio de Salud, Argentina

Session 12: Discovering new toxins in unexpected taxa mammals, amphibians, annelids, crustaceans, ticks – 29th September

29-12-1: “Tick toxins” target vertebrate host wound healing

Pavlína Bartíková¹, Iveta Štibrániová¹, Mirko Slovák², Viera Holíková¹, Valéria Hajnická¹, Patricia A. Nuttall³

¹Ecology of viruses department, Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia

²Department of Medical Zoology, Institute of Zoology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 06 Bratislava, Slovakia

³Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK

29-12-2: Amblyomma variegatum (Acari: Ixodidae) salivary glands are a rich source of antihaemostatic compounds

Mária Kazimírová¹, Cho Yeow Koh², Ladislav Roller¹, Peter Takáč¹, Janaki Krishnamoorthy Iyer², Patricia A. Nuttall³, R. Manjunatha Kini²

¹Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia

²Department of Biological Sciences, National University of Singapore, Singapore

³Department of Zoology, University of Oxford, Oxford, U.K

29-12-3: Pore-forming toxin aerolysin-like proteins (ALPs) in immunity and venoms

Yun Zhang, Yang Xiang, Shen-An Li, Xiao-Long Guo, ling-Yan Wang, Yu-Yan Zhang

Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, China

Session 13: Toxins in natural history and evolution – 29th September

29-13-1: Comparative study of venom biochemical and biological activities of captive and wild Brazilian Viperidae snakes

Karen de Morais-Zani^1,2, Caroline Serino Silva^1,2, Sávio Stefanini Sant’Anna¹, Kathleen Fernandes Grego¹, Anita Mitico Tanaka-Azevedo^1,2

¹Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brazil

²Interunidades em Biotecnolgia, Instituto de Ciências Biomédicas-Instituto de Pesquisas Tecnológicas-Instituto Butantan, Universidade de São Paulo, São Paulo, Brazil

29-13-2: Distribution of the RTS-disintegrin-coding RPLTN gene across Reptilia

Raquel Sanz-Soler, Libia Sanz, Juan J. Calvete

Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain

29-13-3: Comparative Analysis of Venoms from Brazilian Bothrops jararaca snake Born in Captivity and Bothropic Reference Venom

Iasmim Baptista de Farias^1,2, Karen de Morais-Zani^1,2, Sávio Stefanini Sant’Anna¹, Marisa Maria Teixeira da Rocha¹, Kathleen Fernandes Grego¹, Anita Mitico Tanaka-Azevedo^1,2

¹Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brazil

²Interunidades em Biotecnolgia, Instituto de Ciências Biomédicas-Instituto de Pesquisas Tecnológicas-Instituto Butantan, Universidade de São Paulo, São Paulo, Brazil

29-13-4: Transcriptomic differences in the venom of Mohave rattlesnakes (Crotalus scutulatus) are dictated by presence or absence of toxin genes

Giulia Zancolli¹, John Mulley¹, Wolfgang Wüster¹

¹School of Biological Sciences, Bangor University, Deiniol Road, Bangor LL57 2UW, UK

Session 14: Venoms as an emerging evolutionary model – 26th September

26-14-1: Gene regulatory elements and evolution of snake toxins

Summer Xia Han, and R. Manjunatha Kini

Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore

Session 15: Marine and freshwater algal and dinoflagellate toxins – 28th September

28-15-1: Effect of growth conditions over TTX-like compounds produced by Prorocentrum minimun

Amparo Alfonso¹, Ines Rodriguez¹, Eva Alonso¹, Mercedes R. Vieytes² Ana M. Botana³, and Luis M. Botana¹

¹Departamento de Farmacología. ²Departamento de Fisiología. Facultad de Veterinaria. Universidad de Santiago de Compostela. Campus de Lugo. 27002 Lugo. Spain.

³Departamento de QuimicaAnalitica. Facultad de Ciencias. Universidad de Santiago de Compostela. Campus de Lugo. 27002 Lugo. Spain

Session 16: Toxins and the haemostatic system – 28th September

28-16-1: Structural Analysis of Snake Venom Serine Proteinases

Anwar Ullah, Rehana Masood, Ricardo Mariutti, Mônika A Coronado, Raphael J Eberle, Liege Kawai, Raghuvir K Arni

Multiuser Center for Biomolecular Innovation, Department of Physics, IBILCE/UNESP, São Jose do Rio Preto-SP, Brazil

Session 18: Advances in the understanding of bacterial and fungal toxins – 29th September

29-18-1: A Novel Method of Detoxification of the Mycotoxin, Ochratoxin-a, as a Contaminant of Wine Using Yeast (Saccharomyces cerevisiae): Toxicological Studies and Current Progress

Asha Jaja-Chimedza^1,2, Aaron Welch³ and John P. Berry¹

¹Department of Chemistry and Biochemistry, Florida International University, 3000 NE 151^st Street, North Miami, FL 33181, U.S.A.

²School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, U.S.A. (current address) ³Chaplin School of Hospitality and Tourism Management, Florida International University, 3000 NE 151^st Street, North Miami, FL 33181, U.S.A.

29-18-2: Intracellular potassium leakage may directly induce the oligomerization of NLRP3

Yang Xiang, Yun Zhang

Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China

29-18-3: Probing the functional basis for pore-forming activity of cholesterol-dependent cytolysin vaginolysin

Milda Zilnyte¹, Česlovas Venclovas¹, Rima Budvytyte², Tadas Penkauskas², Gintaras Valincius², Aurelija Zvirbliene¹, Milda Pleckaityte¹

¹Institute of Biotechnology, Vilnius university, Vilnius, Lithuania

² Institute of Biochemistry, Vilnius university, Vilnius, Lithuania

Session 19: Venom and toxin pharmacology – 26th September

26-19-1: Pharmaco-modulation of Gastric Inflammatory Response by Histamine H4 Receptor and Cyclooxygenase 2 Pathway during scorpion envenomation

Sonia Adi-Bessalem, Amal Lamraoui, Fatima Laraba-Djebari

USTHB, Faculty of Biological Sciences, Laboratory Cellular and Molecular Biology, Department Cellular and Molecular Biology, Algiers, Algeria

26-19-2: TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom

Aouatef Ait-Lounis and Fatima Laraba-Djebari

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 El-Alia, Bab Ezzouar, 16111, Algiers, Algeria

26-19-3: Morphological and functional alteration of erythrocyte ghosts caused by vipers venom

Gayane Kirakosyan, Hasmik Tadevosyan, Naira Zaqaryan, Arsen Kishmiryan, Naira Ayvazyan

Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan, RA

26-19-4: Involvement of signaling pathways in the induced neuropathological disorders by Kaliotoxin

Amina Ladjel-Mendil¹, Marie-France Martin-Eauclaire² and Fatima Laraba-Djebari¹

¹USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP  32 El-Alia, Bab Ezzouar, Algiers, Algeria

²CNRS UMR 7286, CRN2M, Aix-Marseille University, Faculté de Médecine Nord, Marseille, France

26-19-5: IL-6 and TNF-α involvement in immuno-inflammatory response and oxidative stress induced by Androctonus scorpion venom

Taibi-Djennah Zahida, Ladjel-Mendil Amina and Laraba-Djebari Fatima

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology; BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria

26-19-6: Exposure of lactating rats to the Tityus bahiensis scorpion venom: Effects on behavioral development, neuronal intactness and cytokine levels

Adriana N Martins¹, Ana L C Dorce¹, Camila B P Fusco¹, Emídio B Neto¹, Jorge C Flório², Lucas A Freitas¹, Maria E F V Paulo¹, Valquiria A C Dorce¹, Ana L A Nencioni¹

¹Pharmacology Lab, Butantan Institute, São Paulo, Brazil

²Departament of Pathology, Faculty of Veterinary Medicine and Zootechny, USP, São Paulo, Brazil

26-19-7: First recombinant expression and biological characterization of an ICK toxin from Loxosceles intermedia (brown spider)

Gabriel O. Meissner^1,2, Fernando H. Matsubara¹, Volker Herzig², Glenn F. King², Silvio S. Veiga¹, Olga M. Chaim¹

¹Department of cell biology, Federal University of Paraná, Curitiba, PR, Brazil

²Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Qld, Australia

26-19-8: Cytotoxicity of Apis mellifera Bee Venom: Pharmacological interventions and treatment

Paulo A. Melo¹, Jhonatha M. Teixeira-Cruz¹; Matheus S. Tavares-Henriques¹; Marcelo A. Tomaz¹; Marcos Monteiro-Machado¹; Marcelo A. Strauch^1,2;  Luis E. R. Da Cunha²; Lucilene D. dos Santos³; Benedito Barraviera³; Rui Seabra Ferreira-Junior³

¹Farmacologia, CCS, UFRJ, Rio de Janeiro, RJ,Brazil

²Instituto Vital Brazil, Niterói, RJ, Brazil

³CEVAP, Botucatu, S.P., Brazil

26-19-9: Delineating a potassium channel blocking peptide segment from spinoxin (αKTx6.13), a Kv1 channel inhibitor from Heterometrus spinifer scorpion venom

Selvanayagam Nirthanan¹, Yoko Yamaguchi², Yuko Sugahara², Steve Peigneur³, Takeru Nose⁴, Ponnampalam Gopalakrishnakone⁵, Kazuki Sato², Jan Tytgat³

¹School of Medicine and School of Medical Science, Griffith University, Gold Coast, Queensland, Australia

²Department of Environmental Science, Fukuoka Women’s University, Fukuoka, 813-8529, Japan

³Toxicology and Pharmacology, University of Leuven (KU Leuven), 3000 Leuven, Belgium

⁴Faculty of Arts and Science, Kyushu University, Fukuoka, 819-0395, Japan

⁵Yong Loo Lin School of Medicine, National University of Singapore, Singapore

26-19-10: Investigation of cytotoxicity of Bothrops atrox venom and purified LAAO in primary keratinocytes

Fernanda C. Oliveira¹; Clara G. Duarte¹; Leticia L. de Souza¹; Eladio O. F. Sanchez²; Carlos D. C. Olortegui¹, Vania M. M. Braga³

¹Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brazil

²Fundação Ezequiel Dias, Belo Horizonte 30510-010, MG, Brazil

³Molecular Medicine Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, London SW7 2AZ, U.K.

26-19-11: The effect of Dipotassium Glycyrrhizinate to minimize the myonecrosis induced by Bothrops jararacussu snake venom and to induce muscle regeneration

Thais C. Bueno¹, Marta Gracia¹, Laís S. Nascimento¹, Jussara Ziegler¹, Maria Alice da Cruz-Höfling², Thalita Rocha^1,2

¹Multidisciplinary Research Laboratory, San Francisco University, Bragança Paulista SP, Brazil

²Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas, Campinas SP, Brazil

26-19-12: Effects of an anti-muscarinic component isolated from Micrurus lemniscatus venom on inositol phosphate and learning and memory in rats

Roberta F Santos¹, Tatiana S Satake¹,Fernando M Abdalla¹, Gilberto F Xavier², Maria R Sandoval¹

¹Lab of Pharmacology, Butantan Institute, São Paulo, Brazil

²Lab of Neuroscience and Behaviour, Institute of Biosciences/University of São Paulo, São Paulo, Brazil

26-19-13: Determination of toxic activities in Bothrops spp. snake venoms using animal-free approachs: Correlation between in vitro versus in vivo assays

Stephanie Stransky¹ ; Leticia L. de Souza¹; Clara G. Duarte¹; Ana Flor-Sá¹; Francisco S. Schneider¹; Evanguedes Kalapothakis²; Carlos Chavez- Olortegui¹

^1,2Departamentos de Bioquímica e Imunologia and Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brazil

26-19-14: Ex-vivo evaluation of the electrophysiological effects of the crude venom of Buthotus schach on rat brain neurons

Akram Aboutorabi¹, Hamid Gholamipour-Badie², Nima Naderi¹, Saba Vatanpour³, Maryam kakanj¹ and Hossein Vatanpour¹

¹Department of Toxicology and Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

²Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran

³Department of Sciences University of British Columbia, BC, Canada

26-19-15: A novel tarantula venom peptide with subtype-dependent pharmacology at voltage-gated sodium channels

Joshua S. Wingerd¹, Yanni Chin¹, Mehdi Mobli², Richard J. Lewis¹ and Lachlan D. Rash¹

¹Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia

²Centre for Advanced Imaging & School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia

29-19-16: Effect of Crotalus durissus terrificus venom, Bothrops ammodytoides venom its acidic phospholipase A₂ on leukaemic cell lines K562 and KV562

Vanessa Costa de Oliveira ^1,5, Silvina Lompardía ², Herlinda Clement ³, Gerardo Corzo ³, Silvia Hajos ², Eduardo Amantini⁴, Eduardo Gould⁴, Carlos Damín ⁵, Ernesto de Titto ⁶, Adolfo de Roodt ^1,5,6

¹LabToxpat, CPEyA, Fac. de Medicina, Universidad de Buenos Aires, Argentina

²IDEU-CONICET / Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina

³ Instituto de Biotecnología, Universidad Autónoma de México, Cuernavaca, Morelos, México

⁴Fundación de Estudios Biológicos, CABA, Argentina.

⁵Cátedra de Toxicología, Facultad de Medicina, Universidad de Buenos Aires, Argentina

⁶Ministerio de Salud de la Nación, Argentina

29-19-17: Neutralization, by two antivenoms, of the neuromuscular blocking activity of the venom of taipan (Oxyuranus scutellatus) and its neurotoxin taipoxin

María Herrera¹, Rita de Cássia O. Collaço², Mauren Villalta¹, Álvaro Segura¹, Mariángela Vargas¹, Guillermo León¹, David Williams^3,4, Léa Rodrigues-Simioni² and José María Gutiérrez¹

¹Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José  Costa Rica

²Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas SP  Brazil

³Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia

⁴School of Medicine & Health Sciences, University of Papua New Guinea, Port Moresby Papua New Guinea

29-19-18: Proteomic analysis and species specificity of the venom of the Mexican coral snake Micrurus browni

Melisa Bénard-Valle¹, Enrique Jiménez Ferrer², Edgar Neri-Castro^1,3, Bruno Lomonte⁴ and Alejandro Alagón¹

¹Instituto de Biotecnología, Universidad Nacional Autónoma de México. Av. Universidad # 2001 Col. Chamilpa. CP: 62210. Cuernavaca, Morelos. México

²Instituto de Investigación Biomédica del Sur, IMSS. Xochitepec, Morelos. México

³Centro de Ciencias Genómicas, UNAM.⁴Instituto Clodomiro Picado, Universidad de Costa Rica. San José, 11501, Costa Rica

Session 21: Marine and freshwater stings and venoms – 29th September

29-21-1: Analysis in vivo of sublethal effects of venom from the jellyfish Chrysaora sp. in zebrafish (Danio rerio)

Mayra P Becerra¹, Xochitl Guzmán³, Isabel Guerrero⁴, Saúl A López³, Misael Hernández³, Irma Hernández³, Humberto González²

¹PhD Experimental Biology student, ²Department of Health Sciences, ³Department of Hydrobiology, ⁴Department of Biotechnology, Metropolitan Autonomous University, Iztapalapa, San Rafael Atlixco 186, Vicentina, Iztapalapa, Mexico city, Federal District, Mexico

29-21-2: Tetanus after envenomations caused by freshwater stingrays

Pasesa P.Q.Torrez ¹, Mariana M. Quiroga¹,  Renato Said ¹, Paulo A.M. Abati¹, Vidal H. Júnior², Francisco O. S. França^1,3

¹Advanced Tropical Medicine Center, Santarém, Pará of the Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

²Departament of Dermatology and Radiotherapy, School of Medicine, Paulista State University (UNESP – Botucatu Campus)

³Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, SP, Brazil

29-21-3: Injuries by fish in fishing communities in the Southeast and Midwest Brazil: frequency, clinical aspects, treatment and prevention

Vidal Haddad, Junior

Department of Dermatology, Botucatu Medical School, São Paulo State, Brazil

29-21-4: Comparative study of the cytotoxic effects of Chrysaora quinquecirrha (Scyphozoa) and Chironex fleckeri (Cubozoa) venoms using cell-based assays

Dalia Ponce ^{1, 2}, Karen Luna-Ramírez ¹, Christine E. Wright ^{1, 2}, Diane L. Brinkman ³, Juan José Dorantes-Aranda ⁴

¹Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia

²Cardiovascular Therapeutics Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia

³Australian Institute of Marine Science, P. M. B. No 3, Townsville Mail Centre, Townsville, Queensland 4810, Australia

⁴Institute for Marine and Antarctic Studies, University of Tasmania, Private Bag 129 Hobart, Tasmania 7001, Australia

29-21-5: Treatment for jellyfish stings

Huahua Yu, Jinhua Feng, Rongfeng Li, WeiXue, Pengcheng Li

Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China

29-21-6: Development of realistic, quantitative and repeatable cnidarian envenomation models to standardize treatment testing

Christie L Wilcox¹, Rebecca King¹, Angel A Yanagihara^1,2

¹Pacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI, USA

²Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, Honolulu, HI, USA