Influenza 2015

The conference promises to provide a relaxed, friendly and intellectually-stimulating discussion forum, and will feature:

o Emerging and cutting-edge topics addressing most aspects of basic and applied research on zoonotic and human influenza viruses
o Keynote addresses by world leaders in influenza research
o Distinguished faculty comprising senior and junior scientists
o Global participation by scientists from academia, industry and government organisation
o Excellent networking opportunities

INF15Keynote

The Conference will cover the following general areas of influenza research:-

o Molecular and structural virology
o Immunology and vaccination
o Host-pathogen interaction – virulence and pathogenecity
o Epidemiology and evolution
o National and international surveillance and contingency strategies
o Advances in viral detection and identification technologies

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RV15-bannerRespiratory Viruses 2015 – Serology and Sero-Surveillance

Co-located Pre-conference Symposium
7th September 2014
St Hilda’s College, Oxford

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Speaker and agenda

Session 1: Public health and virus transmission

14.30: Dr Richard Pebody
Acting head, Respiratory Diseases Department, Centre of Infectious Disease Surveillance and Control, Public Health England, UK
Influenza surveillance and the challenge of evaluating the national influenza vaccine programme

15.00: Professor Jonathan Van-Tam (Keynote Speaker)
Professor of Health Protection, University of Nottingham, UK
Human challenge transmission experiments – failure of a quarantine based model 

15.40: Refreshment break and networking

Session 2: Structural and molecular biology

16.10: Professor Wendy Barclay
Professor of Virology, Imperial College London, UK
Species difference in host protein ANP32A underlies influenza A polymerase host restriction host protein

16.40: Professor Ervin Fodor
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Molecular mechanisms of influenza virus replication

17.10: Dr Xiaoli Xiong
The Francis Crick Institute, Mill Hill Laboratory, London, UK
Structures of complexes formed by H5 influenza haemagglutinin and a potent human monoclonal antibody
 

17.40: Dr Pawel Zmora
Infection Biology Unit, German Primate Center, Germany
The stem region of type II transmembrane serine proteases is a determinant of influenza virus activation

18.00: Miss Claire Scott
St James’ University Hospital, University of Leeds, UK
Structure-guided design of novel inhibitors targeting the drug resistant M2 proton channel from pandemic swine influenza

18.20: close

Day 2: 9th September 2015, Jacqueline Du Pré Music Building (JdP)
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Session 3: Vaccines, immunology, antivirals

09.00: Professor Sarah Gilbert
Professor of Vaccinology, University of Oxford, UK
Further clinical assessment of vaccines designed to boost T cell responses to conserved Influenza A antigens

09.30: Professor James Stewart
University of Liverpool, UK
The putative antimicrobial peptide BPIFA1/SPLUNC1 restricts Influenza A virus infection in the host

10.00: Professor Bernadette M Dutia
The Roslin Institute & Royal (Dick) School of Veterinary Studies, Edinburgh, UK
Acute influenza A pathogenesis is ameliorated in a murine model of latent gamma herpesvirus infection

10.30: Refreshment break and networking

11.00: Professor John Oxford
Blizard Institute, Queen Mary College, London
Serological techniques and the formulation and tests of a Universal Influenza Vaccine

11.30: Professor Alain Townsend
Weatherall Institute, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
S-FLU – A pseudotyped influenza virus vaccine that provides broad “heterotypic” protection against group 1 and 2 influenza A viruses in mice and ferrets

12.00: Dr Anthony Marriott
Public Health England, UK
Animal models for influenza

12.30: Dr Elma Tchilian
The Pirbright Institute, Woking, Surrey, UK
Distinct immune responses and viral shedding patterns in pigs following aerosol, intranasal and in contact infection with pandemic H1N1 swine influenza virus

12.50: Lunch and networking

Session 4: Zoonotic

14.10: Dr Sylvia S Reemers
MSD Animal Health, Boxmeer, The Netherlands
A potential broadly protective avian influenza vector vaccine

14.40: Professor Kristien Van Reeth
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan, Merelbeke, Belgium
Heterologous prime-boost vaccination with H3N2 influenza viruses of swine, or “going broad” with killed influenza vaccine

15.10: Professor Ian Brown (Keynote)
Director of EU/FAO/OIE Reference Laboratory for Avian & Swine Influenza, Animal and Plant Health Agency-Weybridge, United Kingdom; Visiting Professor in Avian Virology, University of Nottingham, UK
New and re-emerging challenges for the detection and control of zoonotic animal influenza

15.50: Refreshment break and networking

16.30: Professor Dr Timm Harder
Institute of Diagnostic Virology, Friedrich Loeffler Institute, Greifswald-Riems, Germany
Sessile or mobile: Why do certain lineages of HPAIV H5 show geographic mobility and others not?

17.00: Dr Sharon Brookes
Animal and Plant Health Agency, UK
An update on pandemic influenza H1N1 (A/H1N1pdm09) in pigs 2009-2014

17.30: Mrs Caroline Warren
Animal and Plant Health Agency (APHA) Virology Department, New Haw, Surrey, UK
Modelling the survival of avian influenza viruses in commercial poultry scenarios

17.50: Close

19.00: Networking Dinner (by prior booking or invitation only)

Day 3: 10th September 2015, Jacqueline Du Pré Music Building (JdP)
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Session 5: Detection and assay development

Chairs: Dr Nigel Temperton and Dr Simon Scott

09.00: Professor Emanuele Montomoli
University of Siena and CSO VisMederi srl, Italy
Immunological assays for Influenza vaccines evaluation 

09.30: Dr Simon Scott
Viral Pseudotype Unit, School of Pharmacy, University of Kent, Central Avenue, Chatham Maritime, UK
Development of a pseudotype virus-based neutralization assay for seal influenza virus serological screening

09.50: Dr Nigel Temperton
School of Pharmacy, University of Kent, UK
The application of pseudotypes to Influenza pandemic preparedness

10.10: Dr Scott M Reid
Animal and Plant Health Agency (APHA-Weybridge), UK
Development and validation of molecular tools for sub-typing swine influenza viruses

10.30: Miss Sahar Mahmood
Animal and Plant Health Agency (APHA-Weybridge), UK
The importance of maintaining an accurate and sensitive Real Time PCR testing capability to detect current avian influenza virus threats of diverse origins

10.50: Dr Genyan (Patrick) Yang
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
Subtyping Influenza A Virus by cDNA Hybridization and Sequence-independent Amplification

11.10: Mr Jose C Mancera-Gracia
Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
A role for swine in the adaptation of H9N2 avian influenza viruses to humans?: Lessons from serial passages and transmission studies in pigs

11.30: Lunch and close


Posters

Preparation and Immunogenicity Evaluation of Influenza A/H7N9 Virus-like Particle

Chu-Yang Chien1, Ming-Tsan Liu2, Sui-Yuan Chang3, Shih-Chung Chang4, Rong-Huay Juang4, Hui-Wen Chen1

1Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan

2National Influenza Center, Centers for Disease Control, Taipei, Taiwan

3Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan

4Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan

Airborne spread of influenza viruses: towards quantifying emissions of virus-aerosols from infected pig and poultry farms

Jose L Gonzales1,  Andre J A Aarnink2,  Thomas Hagenaars1

1Department of Epidemiology, Crisis organization and Diagnostics, Central Veterinary Institute (CVI) part of Wageningen UR, P.O. Box 65, 8200 AB Lelystad, the Netherlands.

2Wageningen UR Livestock Research, Wageningen, the Netherlands

Delayed immune response in interferon regulatory factor 3 (Irf3) knock-out mice after influenza A infection

Hang TT Hoang1,2, Bastian Hatesuer1,2and Klaus Schughart1,2,3

1Helmholtz Centre for Infection Research, Department of Infection Genetics, Inhoffenstraße 7, 38124 Braunschweig, Germany

2University of Veterinary Medicine Hannover, Hannover, Germany

3University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA

To Study the Effects of Autophage on H5N1 Infection of Immature Dendritic Cells

Chien-Chih Lee1, Ching-Yu Huang1, Jason C. Huang1,2

1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University

2AIDS Prevention and Research Centre, National Yang-Ming University

Modulation of antigen processing of conserved epitopes in the hemagglutinin as a rational design of a cross-protective influenza live vaccine

Young Jae Lee1, Ji Eun Yu1, Paul Kim1, Yo Han Jang1, and Baik Lin Seong1,2

1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University

2Vaccine Translational Research Center, Yonsei University, Seoul, South Korea

CXCR3 ligands derived from myeloid derived suppressor cells are responsible for the recruitment of effector T cells during influenza A virus infection

Sue-Jane Lin1,2,3, Chi-Hsiang Huang1,4, Wayne CW Huang1,4 and Ching-Hwa Tsai5

1Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

2Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

3Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

4School of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

 5Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

Production and protective efficacy of a subunit yeast-expressed H5 vaccine against challenge with H5N1 highly pathogenic avian influenza virus

Agnieszka Maciola1, M Olszewska2, M Pietrzak1, K Zdanowski1, A Protas1, K Grzelak 1, K Śmietanka2, Z Minta2, W Zagorski-Ostoja1, E Kopera1

1Institute of Biochemistry and Biophysics, Polish Academy of Science, Pawińskiego 5A, 02-106 Warsaw, Poland

2National Veterinary Research Institute, Department of Poultry Diseases,  Al. Partyzantow 57, 24-100 Pulawy, Poland

Antigenic and genetic differences relate to vaccine efficacy of avian influenza subunit but not whole inactivated vaccines

Sylvia S. Reemers1, Cornelis A. de Haan2, Jos Dortmans2, Saskia van de Zande1, Peter J. Rottier2, Ian Tarpey1, Ben Peeters3

1MSD Animal Health, Boxmeer, The Netherlands

2Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

3Central Veterinary Institute, Wageningen University and Research Centre, Lelystad, The Netherlands

Pseudotype based neutralisation assays for influenza: a systematic analysis

George W Carnell1, Francesca Ferrara1, Keith Grehan1, Craig P Thompson 1,2,3 and Nigel J Temperton 1

1Viral Pseudotype Unit, Medway School of Pharmacy, The Universities of Greenwich and Kent, Kent, UK

2Department of Zoology, University of Oxford, Oxford, UK

3The Jenner Institute Laboratories, University of Oxford, Oxford, UK

The application of pseudotypes to influenza pandemic preparedness

Francesca Ferrara, Eleonora Molesti and Nigel J Temperton

Viral Pseudotype Unit, Medway School of Pharmacy, The Universities of Greenwich and Kent, Kent, UK

The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection

Ching-Hwa Tsai1 and Sue-Jane Lin2,3,4

1Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

2Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

3Graduate institute of Medical Biotechnology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

4Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Development of dual detection system of real-time PCR for H7 subtype HA genes of avian influenza viruses

Yuta Kuramochi, Yuhei Furuyama and Kenji Tsukamoto

Laboratory of Animal Health 2, School of Veterinary Medicine, Azabu University, Kanagawa 252-5201, JAPAN

Screening Small Molecules for Inhibition of Ebola Virus Cell Entry

Julie Xiao1, Pramila Rijal1, Beibei Wang1,2, Antony Galione3, Alain R Townsend1

1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, UK

2Beijing Ditan Hospital, Beijing

3Department of Pharmacology, University of Oxford, UK



The conference promises to provide a relaxed, friendly and intellectually-stimulating discussion forum, and will feature:

o Emerging and cutting-edge topics addressing most aspects of basic and applied research on zoonotic and human influenza viruses
o Keynote addresses by world leaders in influenza research
o Distinguished faculty comprising senior and junior scientists
o Global participation by scientists from academia, industry and government organisation
o Excellent networking opportunities

INF15Keynote

The Conference will cover the following general areas of influenza research:-

o Molecular and structural virology
o Immunology and vaccination
o Host-pathogen interaction – virulence and pathogenecity
o Epidemiology and evolution
o National and international surveillance and contingency strategies
o Advances in viral detection and identification technologies 

HozBox500x3

RV15-bannerRespiratory Viruses 2015 - Serology and Sero-Surveillance

Co-located Pre-conference Symposium
7th September 2014
St Hilda's College, Oxford

HozBox500x3

Get involved

o Ask a question
o Leave your feedback
o Suggest a speaker or an oral session
 
Email:FluOxford@gmail.com

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