Influenza 2013

See you at Influenza 2014
9-11 September 2014, Oxford, UK

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Summary of Influenza 2013

One Influenza, One World, One Health

17-19 September 2013, St Hilda’s College, Oxford, UK

Influenza2013 addressed basic and applied research on zoonotic and human influenza viruses and covered the following general areas if influenza research:-

Molecular virology and immunology
Antiviral drug development and treatment strategies, including vaccination
Host-pathogen interaction – virulence and pathogenecity
Epidemiology and evolution
Mathematical models
National and international surveillance and contingency strategies
Advances in viral detection and identification technologies

Distinguished Keynote Speakers

Prof David Swayne
Prof Maria Zambon
Prof Yoshi Kawaoka

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Distinguished Faculty

Professor John S Oxford
President and Scientific Director, Retroscreen Virology Ltd (UK), and Professor of Virology at St Bartholomew’s and the Royal London Hospital, Queen Mary’s School of Medicine and Dentistry, London, UK
Title: The Origin of the 1918 influenza pandemic: field studies pathology samples and exhumations

Professor Maria Zambon BSc BM BCh PhD FRCPath FMedSci (Keynote Address)
Director, Reference Microbiology Services, Microbiology Services Division: Colindale, UK Public Health England, London, UK
Title: Clinical and public health challenges of influenza

Professor Giovanni Maga
Head, DNA Enzymology & Molecular Virology Section, Institute of Molecular Genetics IGM-CNR, National Research Council, Pavia, Italy, and Contract Professor in Molecular Biology, University of Pavia, Italy
Title: The different substrate specificities of human influenza virus PA and PA-X endonucleases support distinct roles in the viral life cycle

Professor Paul Digard
Chair of Virology, The Roslin Institute, University of Edinburgh, Edinburgh, UK
Provisional Title: Molecular virology of influenza virus assembly and replication

Dr Catherine Isel
Architecture et Réactivité de l’ARN, Université de Strasbourg, CNRS, IBMC, 15 rue Descartes, 67084 Strasbourg, France
Title: Inter-molecular RNA interactions involved in the co-packaging of the influenza A virus genomic segments

Dr Rupert Beale
MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH
Title: A LIR motif in Influenza M2 is required for virion stability

Dr Roger Thomas
Professor of Family Medicine, University of Calgary, Alberta, Canada
Title: What is the evidence that influenza vaccines are effective?

Professor Yoshihiro Kawaoka DVM MS PhD (2nd WG Laver Lecture)
Professor of Virology, Department of Pathobiological Science, University of Wisconsin (Madison), USA, and the University of Tokyo, Japan

Dr Bernadette M Dutia
The Roslin Institute and R(D)SVS, University of Edinburgh, UK
Title: Macrophages and the early response to influenza virus infections

Dr Nigel Temperton
Principal Scientist, Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK
Title: The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach

Dr Yannick Gardin
Director, Biology Innovation Strategy, Ceva Animal Health, France
Title: Interest of rHVT-HA(H5) vector vaccine in the control of Avian Influenza

Dr Stephane Lemiere
Technical Director, Merial, France
Title: Control by vaccination of low pathogenic avian influenza in commercial poultry

Dr Richard Sugrue
Division of Molecular and Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore
Title: Systems-based approach to analyse the host response to avian influenza viruses

Dr Qibo Zhang
Principal Investigator and Lecturer in Immunology, Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, UK
Title: 2009 H1N1 infection primes for immunological memory in human nasal-associated lymphoid tissue that offers cross-reactive immunity to H1N1 and avian H5N1 viruses

Dr Matthew Scotch
Assistant Professor, Department of Biomedical Informatics, Arizona State University, Arizona, USA
Title: Phylogeography of avian and human influenza in the Southwest United States

Professor David Swayne DVM MSC PhD (Keynote Address)
Laboratory Director, Southeast Poultry Research Laboratory, USDA/Agricultural Research Service, Georgia, USA
Title: Understanding the 2013 H7N9 avian influenza outbreak in poultry: field epidemiology and experimental pathogenesis studies

Professor Ian Brown
Director, International Reference Laboratory for Avian Influenza, Virology Department, Animal Health and Veterinary Laboratories Agency (AHVLA), Surrey, UK
Title: Global activity with animal influenza and challenges for surveillance

Dr Munir Iqbal
Principal Investigator, Avian Influenza Group, Avian Viral Diseases Programme, The Pirbright Institute, Compton, UK
Title: Infectivity and transmissibility of H9N2 avian influenza virus in chickens and wild terrestrial birds

Dr Guus Koch
Wageningen University & Research Centre, The Netherlands
Provisional Title: Avian influenza epidemiology and immunology

Dr Hugo Gomes da Silva
Global Medical Affairs Leader, GalaxoSmithKline, Belgium

Dr Anthony Marriott
Public Health England, Porton Down, Salisbury, UK
Title: Refinement of the ferret model of influenza infection

Dr Beffagna Giorgia
Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy
Title: Establishment of a mouse model to evaluate pancreatic colonization by influenza A viruses and its metabolic consequences

Dr Bastian Hatesuer
Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
Title: Tmprss2 deficient mice are resistant to spreading and pathology after H1N1 influenza A virus infection

Dr Camilla Benfield
The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK
Title: The Antiviral Potential of Interferon-Induced Transmembrane Protein 3 (IFITM3) in Pigs and Bats

Dr Solvej Bruem
National Veterinary Institute, Technical University of Denmark, Frederiksberg, Denmark
Title: Novel reassortant swine influenza viruses are circulating in Danish pigs

Dr Sarah Gildea
Virology Unit, The Irish Equine Centre, Johnstown, Naas, Ireland
Title: Over half a decade of equine influenza virus surveillance in Ireland – it’s international importance

Miss Kristina Fobian
National Veterinary Institute, Technical University of Denmark, Frederiksberg, Denmark
Title: Genetic and antigenic characterization of influenza A virus circulating in Danish swine during the past decade

Professor James Wood
Alborada Professor of Equine and Farm Animal Science, University of Cambridge, UK
Title: TBA

Mr Himanshu Manchanda
Leibniz Institute for Natural Product Research and Infection Biology –Hans Knöll Institute, Beutenbergstrasse 11a, 07745 Jena, Germany, and Jena University Hospital, Department of Virology and Antiviral Therapy, Hans-Knoell-Strasse 2, 07745 Jena, Germany
Title: Mathematical modeling of pandemic Influenza A virus-induced disease in mice

Dr Kim Roberts
Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Ireland
Title: The short stalk length of HPAI H5N1 influenza neuraminidase limits virus transmission in ferrets

Dr Holly Shelton
Avian Infectious Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, Berkshire, UK
Title: Mutations in hemagglutinin that affects receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

Miss Samantha Kasloff
Department of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’Università, Italy
Title: Susceptibility of Human-Origin Pancreatic Tumour Cell Lines to Influenza A Virus Infection

Miss Nora Seidel
Jena University Hospital, Department of Virology and Antiviral Therapy, Hans-Knoell-Strasse 2, 07745 Jena, Germany
Title: Drug susceptibility of swine influenza A viruses isolated in Germany

Ms Miriam Klausberger
Institute of Applied Microbiology, University of Natural Resources and Life Sciences, Vienna, AUSTRIA
Title: Efficacy and immunogenicity of an insect cell-derived virus-like particle vaccine for the novel Chinese H7N9 influenza virus in mice

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Posters Presented at Influenza 2013

(Presenters in Bold)

Aptamers for the diagnosis of avian influenza viruses infecting poultry

Beata Adamiak 1, Thao Le 2, Sanjiv Sharma 2 , Christopher Johnson 2, Rob Fenton 2, John W McCauley 3, Anthony EG Cass 2, Munir Iqbal 1,

1 Avian Viral Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, UK, 2 Department of Chemistry and Institute of Biomedical Engineering, Imperial College London, 3 Division of Virology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

SimFlu: a simulation tool for predicting the variants of influenza A viruses

Insung Ahn 1, and Hyeon S. Son 2

1 High-performance Biocomputing Team, National Institute of Supercomputing and Networking, Korea Institute of Science and Technology Information, 245 Daehak-Ro, Yuseong-Gu, Daejeon 305-806, Korea, 2 Laboratory of Computational Biology & Bioinformatics, Institute of Health and Environment, Graduate School of Public Health, Seoul National University, 599 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Korea

Influenza Vaccination using Dissolvable Microneedle Transcutaneous Patches in Pre-clinical Models Induces a Broad Antibody Response

E. Allen 1, A. Crean 1, F. Ferrara 2, N. Temperton 2 and A. Moore 1

1 School of Pharmacy, University College Cork, Cork, Ireland, 2 Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Chatham, Kent, UK

Morphological differences between influenza A viruses grown in avian host cells

Al-Mubarak FT, Daly JM, Dunham SP

School of Veterinary Medicine and Science, University of Nottingham, College Road, Sutton Bonington, LE12 5RD, UK

Coordinated surveillance of influenza viruses in European pigs: Enhanced virological and epidemiological analysis from the European Surveillance Network for Influenza in Pigs (ESNIP3)

Ian H. Brown 1 * , Scott M. Reid 1, Gaëlle Simon 2, Willie Loeffen 3, Lars E. Larsen 4, Paul Kellam 5, Nicola Lewis 6, Sharon M. Brookes 1 and ESNIP3 Consortium 7

1 Virology Department, Animal Health and Veterinary Laboratories Agency–Weybridge, Addlestone, United Kingdom, KT15 3NB, 2 Anses, Ploufraga n-Plouzané Laboratory, Swine Virology Immunology Unit, Ploufragan, France. 3 Central Veterinary Institute of Wageningen UR (CVI-Lelystad), The Netherlands, 4 Technical University of Denmark, National Veterinary Institute, Copenhagen, Denmark. 5Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA. 6 University of Cambridge, Centre for pathogenic evolution, Downing Street, Cambridge, CB2 1TN. 7 FP7-INFLUENZA-2010, Grant #259949, Coordinated Action ESNIP3.

The detection of a low pathogenicity avian influenza virus subtype H9 infection in breeder turkeys in the United Kingdom

Vanessa Ceeraz 1, William J Cox 1, Scott M Reid 1, Wendy A Howard 1 , Anita Puranik 1 , Susan Collins 1 , Ruth Manvell 1 , Richard M Irvine 1 , Ian H Brown 1

1 Department of Avian Virology, Animal Health and Veterinary Laboratories Agency-Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB

Genetic Diversity of Avian Influenza A virus in Free-Grazing Ducks Surveillance in 2010-2013 in Thailand

Supassama Chaiyawong 1,2, Supanat Boonyapisitsopa 1,2, Waleemas Jairak 1,2, Nutthawan Nonthabenjawan 1,2, Ratanaporn Tangwangvivat 1,2, Kirana Noradechanon 1,2, Napawan Bunpapong 1, Alongkorn Amonsin 1,2

1 Center of Excellence Emerging and re-emerging Infectious Diseases in Animals, Faculty of Veterinary Science, Chulalongkorn University; 2Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Thailand

SOCS3 -knockdown in porcine primary respiratory epithelial cells reduces influenza virus replication through activation of STAT3

Chang Pengxiang 1 , Suresh V Kuchipudi 1 , Kin-Chow Chang 2

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, College Road, Loughborough, Leicestershire LE12 5RD, UK

A SEROLOGICAL SURVEY OF INFLUENZA A VIRUS INFECTION IN DOGS IN BANGKOK

Sunicha Chanvatik1, Ratanaporn Tangwangvivat1, Duangduean Prakairungnamthip2, Aunyaratana Thontiravong2, Alongkorn Amonsin1

1Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330 Thailand, 2Virology Unit, Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand

Assessment of Influenza-associated Excess Mortality in Taiwan

Hung-Wei Kuo 1, Yi-chen Tsai 1, Chiu-Hsiang Lin 1, Chiu-Mei Chen 1 , Shiang-Lin Yang 1, Jen-Hsiang Chuang 2

1 Epidemic Intelligence Center, Centers for Disease Control, R.O.C., 2 Director of Epidemic Intelligence Center, Centers for Disease Control, R.O.C.

Emergence of multiple H5N1 clade 2.3.2.1 subgroups in Vietnam and detection of novel reassortants

Todd Davis 1, Adrian Creanga 1,2, Diep Thi Nguyen 3,4, Nancy Gerloff 1, Hoa Thi Do 3, Amanda Balish 1, Hoang Dang Nguyen 3, Yunho Jang 1, Vui Thi Dam 3, Sharmi Thor 1, Joyce Jones 1, Natosha Simpson 1, Bo Shu 1, Shannon Emery 1, LaShondra Berman 1, Steve Lindstrom 1, Alexander Klimov 1, Ruben O. Donis 1, Tung Nguyen 3,5

1 Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA USA, 2 Battelle Memorial Institute, Atlanta, GA, USA, 3 National Centre for Veterinary Diagnostics, Department of Animal Health, Hanoi, Vietnam, 4 Centre for Tropical Medicine, Nuffield Dept. of Medicine, University of Oxford, Oxford, UK, 5 Graduate School, Hanoi University of Agriculture, Hanoi, Vietnam

Molecular Pathogenesis of Avian Influenza Virus in Avian Hosts

Donna Fountain 1 , Dr Marek J Slomka 2, Dr Stephen P Dunham 1

1 School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, UK, 2 Virology Department, Animal Health & Veterinary Laboratories Agency, Weybridge, Addlestone, UK

Increased risk of swine influenza in pig industry workers compared to the general population in the UK

E Fragaszy 1,2, D Ishola 1, I Brown 3, J Enstone 4, JS Nguyen-Van-Tam 4, R Simons 3, D Tucker 5, B Wieland 6, S Williamson 3, COSI Consortium, AC Hayward 1, J Wood 5

1 UCL, Research Department of Infection and Population Health, London, UK, 2 London School of Hygiene and Tropical Medicine, Department of Infectious Disease Epidemiology, London, UK, 3 Animal Health and Veterinary Laboratories Agency (AHVLA), Weybridge, UK, 4 Health Protection and Influenza Research Group, Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK, 5 Cambridge University, Department of Veterinary Medicine, Cambridge, UK, 6 Royal Veterinary College, North Mymms, UK

Genetic requirements that support H7N7 HPAI phenotype

Amanda Hanna 1,2 , Wendy A. Howard 1, Alejandro Núñez 1, Wendy S. Barclay 2 and Jill Banks 1

1 Avian Influenza, Animal Health & Veterinary Laboratories Agency (AHVLA-Weybridge), UK, 2 Section of Virology, St. Mary’s Campus, Imperial College, London, UK

Prosite discovery: A novel approach for surveillance, prediction and control of highly pathogenic avian influenza (HPAI) outbreaks

Farhid Hemmatzadeh 1, Esmaeil Ebrahimie 1, Simson Tarigan 2, Risa Indriani 2, Sumarningsih 2,NLP Indi Dharmayanti 2 Jagoda Ignjatovic 3

1 School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, Australia, 2 Indonesian Research Centre for Veterinary Science, Bogor, Indonesia, 3 School of Veterinary Science, The University of Melbourne, Melbourne, Australia

Continuous evolution of avian influenza H5N1 clade 2.2.1 sub-lineage C in commercial poultry in Egypt 2013

Hussein.A.Hussein and Mohamed Rohiam

Department of Virology, Faculty of Veterinary Medicine, Cairo University, Egypt

PB1-F2 modulates polymerase activity of Influenza in avian cells but not mammalian cells

W. Howard 1, J. James 2, M. Mura 3, O. Moncorg é 3 , H. Shelton 2 & W. Barclay 3

1 Department of Virology, Animal Health and Veterinary Laboratories Agency-Weybridge, Addlestone, Surrey, UK, 2 Avian Infectious Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, Berkshire, UK, 3 Division of Infectious Diseases, Imperial College London, St Marys Campus, London, UK

Identification of PR8 Genes Imparting High Influenza Hemagglutinin Yield in Eggs

Adam Johnson 1 , Wanda Santana 2, Guaniri Mateu-Petit 1, Carrie Pierce 2, Jaber Hossain 1, Emily Winne 2, Tracie Williams 2, Li-Mei Chen 1, Julie Villanueva 1, Alexander Klimov 1, Jim Pirkle 2, Nancy Cox 1, John Barr 2, Ruben Donis 1

1 Influenza Division, National Center for Immunization and Respiratory Diseases, 2 Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, USA

Development of RP-HPLC Method for Quantification of Haemagglutinin in Influenza Vaccine

Hyunkyung Kang, Hyemin Song, Seung-Tae Chung, Chiyoung Ahn, Shin-jung Kang, Sang Ja Ban

MFDS, 187, Osongsaengmyeong 2-ro, Osong-eup, Cheongwon-gun, Chungcheongbuk-do, 363-700, Korea

Influenza epidemics in northern Sweden and temperature

Urban Kumlin ¹, Joacim Rocklöv², Anders Johansson¹, Niklas Arnberg¹, ¹

Department of Clinical Microbiology; ² Umeå Center for Global Health Research, Umeå University, Sweden

Selective Pressure in the Influenza A H3 Stalk – A Problem for Broad-Spectrum Vaccines?

W.D. Lees 1, D.S. Moss 1, A.J. Shepherd 1

1 Department of Biological Sciences and Institute of Structural and Molecular Biology, Birkbeck College, University of London, Malet Street, London WC1E 7HX UK

Therapeutic efficacy of a novel anti-influenza peptide

Yvonne Ligertwood, Marlynne Q. Nicol, Mathew Bacon, Bernadette M. Dutia and Anthony A. Nash

The Roslin Institute and R(D)SVS, University of Edinburgh, Edinburgh, Scotland, UK

H13 and H16 influenzavirus infections in Finnish gulls

Lindh E 1 , Alasaari J 1, Isomursu M 2, Ek-Kommonen C 3, Väänänen VM 4, Vaheri A 1, Vapalahti O 1, 5, 6, Huovilainen A 3

1 Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, 2 Research and Laboratory Department, Production Animal and Wildlife Health Research Unit , Finnish Food Safety Authority Evira, 3 Research and Laboratory Department, Veterinary Virology, Finnish Food Safety Authority Evira, 4 Department of Forest Sciences, Faculty of Agriculture and Forestry, University of Helsinki, 5 Department of Virology and Immunology, Helsinki University Central Hospital Laboratory, HUSLAB, 6 Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Finland

Genetic and phylogeographic origin of highly pathogenic avian influenza H7N3 in Mexico

Lu Lu, Samantha J Lycett 1 , and Andrew J. LEIGH BROWN 1

1 University of Edinburgh, Institute of Evolutionary Biology, Ashworth Laboratories, Edinburgh, United Kingdom

Swine Influenza Surveillance in Thailand, during 2011-2013

Nutthawan Nonthabenjawan 1,2 , Sunicha Chanvatik 1,2, Kirana Noradechanon 1,2, Ranida Tuanudom 1, Supassama Chaiyawong 1,2, Duangduean Prakairungnamthip 1, Suphot Wattanaphansak 3, Pornchalit Assavacheep 3, Alongkorn Amonsin 1, 2

Host cell protease TMPRSS4 show a minor role in hemagglutinin cleavage in vivo

Nora Mehnert 1 ,Bastian Hatesuer 1, Stephanie Bertram 2, Edith Hummler 3, Stefan Pöhlmann 2, Klaus Schughart 1

1 Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, and University of Tennessee Health Science Center, 38124 Braunschweig, Germany, 2 Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany, 3 Department of Pharmacology and Toxicology, University of Lausanne, 1005 Laussane, Switzerland

Estimating Parameter of Influenza Transmission using Regularized Least Square

Nuning Nuraini 1, Yenie Syukriah 1 , Sapto W. Indratno 1

1 Mathematics Department, Bandung Institut of Technology, Jl. Ganesa 10, Bandung, Indonesia

Distinct replication and shedding trajectories of Low Pathogenic Avian Influenza Virus (LPAI) in inbred lines of chickens

Raul Ruiz-Hernandez , Marylene Peroval, Devanand Balkissoon, Karen Staines, Amy Boyd, Jean-Remy Sadeyen and Colin Butter

The Pirbright Institute, Compton Laboratory, High Street, Compton, RG20 7NN, UK

Investigation of anomalous H1N2 serology results from pigs on farms in Great Britain infected with swine influenza virus

Christine Russell 1, Jayne Cooper 1, Scott Reid 1, Viv Coward 1 , Wendy Howard 1 , Susanna Williamson 2 , Catriona Gaudie 3 , Alex Holland 1 , Ian Brown 1

1 Animal Health and Veterinary Laboratories Agency-Weybridge, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB 2 AHVLA, Rougham Hill, Bury St Edmunds, Suffolk IP30 9AN 3 AHVLA, West House, Station Road, Thirsk, Y07 1PZ

Serological detection of influenza virus in Antarctic penguins, between years 2010 and 2011

Marina Maria Moraes de Seixas1 , Jansen de Araújo1, Tatiana Ometto1, Renata Hurtado1, Lucas Kruger2, Maria Virginia Petry2, Edison Luiz Durigon1

1 Laboratory of Clinical and Molecular Virology, Biomedical Science Institute, São Paulo University, 2 Laboratory of Ornithology and Marine Animals, Vale do Rio do Sinus University

An assessment of H17 HA species tropism

F. Ryrie 1, E. Robinson 2, I. M. Jones 2, H. Shelton 1

1 Avian Infectious Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, Berkshire, UK, 2 School of Biological Sciences, University of Reading, Reading, UK

Cellular RNA editing enzyme ADAR1 interacts with Influenza A virus proteins during infection and enhances virus replication

Nikki Smith 1, Artur A Arikainen 2, Helen Wise 1, Julian Hiscox 3, Paul Digard1

1 The Roslin Institute, The University of Edinburgh, Easter Bush, Edinburgh, UK, 2 University of Cambridge, Cambridge, UK, 3 Institute of Infection and Global Health, University of Liverpool, Liverpool, UK

In vitro evolution of low pathogenic avian influenza H5N1 virus under strong antiviral (oseltamivir) selection pressure studied by next-generation sequencing

Mieke Steensels 1 , Toon Rosseel 2,Thu Giang Nguyen 1, Bénédicte Lambrecht 1, Steven Van Borm 2

1 Veterinary and Agrochemical research Centre, Avian virology and Immunology, Groeselenberg 99, 1180 Ukkel, Belgium, 2 Veterinary and Agrochemical research Centre, Molecular Platform, Groeselenberg 99, 1180 Ukkel, Belgium

Comparison of the pathogenicity of closely related H1N1 influenza A virus PR8 variants

Ruth Stricker 1, Klaus Schughart 1

1 Department of Infection Genetics, Helmholtz Center for Infection Research, University of Veterinary Medicine Hannover, University of Tennessee Health Science Center; Inhoffenstrasse 7, 38124 Braunschweig, Germany

Canine influenza surveillance in animal shelters in Thailand

Ratanaporn Tangwangvivat 1,2, Nutthawan Nonthabenjawan 1,2, Supassama Chaiyawong 1,2, Waleemas Jairak 1,2, Sunicha Chanvatik 1,2, Ranida Tuanudom 1, Duangduean Prakairungnamthip 1, Supanat Boonyapisitsopa 1, Napawan Bunpapong 1, Alongkorn Amonsin 1,2

1 Center of Excellence Emerging and re-emerging Infectious Diseases in Animals, Faculty of Veterinary Science, Chulalongkorn University; 2 Department of Veterinary Public Health, Faculty of Veterinary Science, Chulalongkorn University, Thailand

Development and use of LPAI and HPAI H7 avian influenza pseudotypes for serological studies

Nigel Temperton 1, Eleonora Molesti 1, Francesca Ferrara 1, Giovanni Cattoli 2 and Eva Böttcher-Friebertshäuser 3

Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK, 2 FAO, OIE and National Reference Laboratory for Newcastle Disease and Avian Influenza, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy, 3 Institute of Virology, Philipps University, Marburg, Germany

Development of a pseudotype-based neutralisation assay kit for in-field vaccine evaluation and sero-surveillance of highly pathogenic viruses

Nigel Temperton 1, Stuart Mather 1, Simon Scott 1 and Edward Wright 2

1 Viral Pseudotype Unit, School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK, 2 Business address School of Life Sciences, University of Westminster, London, UK

Are influenza-like illness (ILI) and all-cause mortality appropriate outcome measures to test influenza vaccine effectiveness?

Roger E Thomas

Department of Family Medicine, University of Calgary, Health Sciences Centre 3330 Hospital Drive NW Calgary Alberta Canada T2M 1M1

Use of intravenous peramivir for treatment of seasonal influenza infection s in Taiwan, 2010-2012

Hsiao-Yun Tsai, Yi-Chien Chih, Shu-Mei Chou, Chin-Hui Yang

Centers for Disease Control, R.O.C. (Taiwan) No.6, Linsen S. Rd., Jhongjheng District, Taipei 10050, Taiwan (R.O.C.)

The Role of the Avian Allele of the Influenza A Virus NS1 Protein in Setting Host Range and Pathogenicity

Matt Turnbull 1, Helen Wise 1, Marlynne Quigg-Nicol 1, Rebecca Dunfee 2, Jeff Taubenberger, Bernadette Dutia 1, Paul Digard 1

Department of Infection and Immunity, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda

Detection of antibodies directed towards H5 and H7 in birds

Wallerström S 1,2 , Lagerqvist N 1,2, Temperton N.J 3, Cassmer M 2, Moreno A 4, Karlsson M 2, Olsen B 5, Leijon M 6, Lundkvist Å 1,2,7, Falk K.I 1,2

1 Karolinska Institutet, SE-171 77 Stockholm, Sweden, 2 Swedish Institute for Communicable Disease Control, SE-171 82 Solna, Sweden, 3 Viral Pseudotype Unit, University of Kent, ME4 4TB Kent, United Kingdom, 4 Reparto di Virologia, Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, 25124 Brescia, Italy, 5 Infectious Diseases, Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden, 6 National Veterinary Institute and Swedish University of Agricultural Sciences, SE-751 89 Uppsala, Sweden, 7 IMBIM, BMC, Uppsala University , SE- 751 05 Uppsala, Sweden

Please consider this abstract for a short oral presentation

Intermolecular Interactions in Hemagglutinin subunits HA1 and HA2 Affect Hemagglutinin Stability and Influenza Virus Infectivity

Wei Wang, Esmeralda Alvarado, Christopher J. DeFeo, Russell Vassell, and Carol D.Weiss*

Laboratory of Immunoregulation, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892-4555, USA

The survival of highly pathogenic avian influenza H5N1 and H7N1 viruses in different environmental matrices

Caroline J. Warren 1 ; Chad M. Fuller 1*; David A. Sutton 1; James M. Seekings 1; Elizabeth W. Aldous 1,2; Richard M. Irvine 1; Ian H. Brown 1

1 Virology department, Animal Health and Veterinary Laboratories Agency-Weybridge, KT15 3NB, UK, 2 Now at The Pirbright Institute , Ash Road, Pirbright. UK

Recoding the influenza glycoprotein genes with 618 synonymous mutations lead to a novel live attenuated vaccine

Chen Yang 1 , Steven Skiena 2, Bruce Futcher 1, Steffen Mueller 1*, Eckard Wimmer 1

Departments of 1Molecular Genetics and Microbiology, and 2Computer Science, Stony Brook University, Stony Brook, NY 11794

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Organisations Represented at Influenza 2013

The following organisations are being represented at the conference to-date.

Animal Health Veterinary Laboratories Agency (ahVLA), UK
Arizona State University, USA
AstraZeneca, UK
Bandung Institut of Technology, Indonesia
Baxter Bioscience, Austria
Cairo University, Egypt
Center for Disease Control, Taiwan
Centers for Disease Control and Prevention, USA
Chulalongkorn University, Thailand
CPF (Thialand)
Finnish Food Safety Authority EVIRA, Finland
Food & Drug Administration, USA
Health Science Centre (Calgary), Canada
Helmholtz Center for Infection Research, Germany
INSERM/IBMC, France
Institute of Applied Microbiology, Austria
Institute of Microbiology, China
Institute of Molecular Genetics IGM-CNR, Italy
Iowa State University, USA
Irish Equine Centre, Ireland
Janssen Infectious Diseases-Diagnostics BvBa, Belgium
Janssen Research and Development, Belgium
Jena University Hospital, Germany
Korea Inst of Sci & Tech Information, Korea
MedImmune, UK
MRC Laboratory of Molecular Biology (Cambridge)
Nanyang Technological University, Singapore
Osong Health Technology Administration Complex, Korea
Public Health England, UK
Retroscreen Virology Ltd, UK
Royal Free Hospital, UK
Royal Veterinary College, UK
Stony Brook University, USA
Swedish Institute for Communicable Disease Control, Sweden
Taiwan Center for Disease Control, Taiwan
Technical University of Denmark, Denmark
The Pirbright Institute, UK
Trinity College Dublin, Ireland
Umea University, Sweden
Universidade de São Paulo, Brazil
University College Cork, Ireland
University of Adelaide, Australia
University of Cambridge, UK
University of Edinburgh, UK
University of Helsinki, Finland
University of Kent, UK
University of Liverpool, UK
University of London, UK
University of Nottingham, UK
University of Oxford, UK
University of Padova, Italy
University of Padua, Italy
University of Tokyo, Japan
University of Veterinary Medicine Hannover, Germany
Vet and Agri Res Center, Belgium