Influenza 2012

See you at Influenza 2014
9-11 September 2014, Oxford, UK


  • Summary of Influenza 2012

    One Influenza, One World

    11-13 September 2012, St Hilda's College, Oxford, UK

    Influenza2012 addressed basic and applied research on zoonotic and human influenza viruses and covered the following general areas if influenza research:-

    • Molecular virology and immunology
    • Antiviral drug development and treatment strategies, including vaccination
    • Host-pathogen interaction - virulence and pathogenecity
    • Epidemiology and evolution
    • Mathematical models
    • National and international surveillance and contingency strategies
    • Advances in viral detection and identification technologies
    Distinguished Keynote Speakers
    • Prof Robert Webster
    • Prof Hans-Dieter Klenk
    • Prof ADME Osterhaus

  • Distinguished Faculty

    Professor Adrian Hill
    Jenner Institute, University of Oxford, UK

    Professor Dr Hans-Dieter Klenk (Keynote Address)
    Professor, Institute of Virology, Philipps University, Marburg, Germany
    Title: Determinants of host specificity and pathogenicity of influenza viruses

    Professor Dr Thomas C Mettenleiter
    Präsident, Friedrich-Loeffler-Institut, Germany
    Title: Molecular basis of AIV pathogenicity–polybasic cleavage site revisited

    Dr Mikhail Matrosovich
    Professor, Institute of Virology, Philipps University, Marburg, Germany
    Title: Receptor specificity and interspecies transmission of influenza viruses

    Dr Giovanni Maga
    Head, DNA Enzymology & Molecular Virology Section, Institute of Molecular Genetics IGM-CNR, National Research Council, Italy
    Title: Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus

    Dr Roland Marquet
    Research Director, Université de Strasbourg, CNRS IBMC, Strasbourg, France
    Title: RNA/RNA interactions and the selective packaging of influenza A genomic segments

    Dr Patrick C Reading
    NHMRC RD Wright Fellow, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Title: Glycans on the hemagglutinin of influenza A virus are a target for recognition by soluble and cell-surface C-type lectins

    Dr Solvej Ø Breum
    Division of Veterinary Diagnostics and Research, Technical University of Denmark,National Veterinary Institute, Copenhagen, Denmark
    Title: New influenza A virus reassortments have been found in Danish swine in 2011

    Dr Shu-Ming Kuo
    Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan
    Title: Elongation factor Tu is a host restriction factor in influenza A virus infection

    Professor Wendy Barclay
    Professor, Imperial College London, UK
    Title: Different effects of influenza polymerase mutations in different viruses and in different hosts

    Dr Munir Iqbal
    Principal Investigator, Avian Influenza Group , Avian Viral Diseases Programme,Institute for Animal Health, Compton, UK
    Title: Effect of different glycosylation patterns of the haemagglutinin glycoprotein of H7N1 avian influenza viruses on virus replication and transmission in chickens and turkeys

    Professor Robert Webster FRS
    Rose Marie Thomas Chair, Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA
    Title: Crystallizing the origins of influenza

    Dr El-Sayed M Abd El-Whab
    Friedrich Loeffler Institute, Germany
    Title: Epidemiology and evolution of H5N1 avian influenza virus in Egypt: Lessons learned

    Dr Sharon Brookes
    Animal Health and Veterinary Laboratories Agency (AHVLA), UK
    Title: H9N2 interspecies infection and pandemic preparedness (avian, swine and human)

    Dr Marius Gilbert
    Universite Libre de Bruxelles, Bruxelles, Belgium
    Title: Spatial epidemiology of Highly Pathogenic Avian Influenza H5N1 in poultry: What have we learned?

    Dr Mariya V Sivay
    Novosibirsk State University, Novosibirsk, Russia
    Title: Surveillance for avian influenza viruses in the Western Siberia (Russia), 2008-2011

    Miss Jennifer Summers
    Department of Public Health, University of Otago, Wellington, New Zealand
    Title: Comparison of 1918-19 and 2009 H1N1 influenza pandemics: Epidemiology and lessons learnt

    Dr Guillaume Fournié
    Veterinary Clinical Sciences Department, Royal Veterinary College, University of London, UK
    Title: The potential of live bird markets to maintain and spread avian influenza A (H5N1) virus: a survey of markets in northern Vietnam and Cambodia and mathematical models of transmission

    Miss Denise Kuehnert
    Department of Computer Science, University of Auckland, New Zealand
    Title: Phylodynamic analysis of Influenza virus from structured populations

    Dr Nuning Nuraini
    Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia
    Title: Simulation for optimal vaccination strategy of bird flu

    Dr Laurence Tiley
    Senior Lecturer in Molecular Virology, University of Cambridge, UK
    Title: Designer chickens for combating avian influenza

    Dr Nigel Temperton
    Senior Lecturer and Principal Scientist, Viral Pseudotype Unit (VPU), Medway School of Pharmacy, University of Kent, UK
    Title: Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies

    Dr Francesca Ferrara
    Viral Pseudotype Unit (VPU), Medway School of Pharmacy, University of Kent, UK
    Title: The human Transmembrane Protease Serine 2 (TMPRSS2) cleaves the haemagglutinins of all Group 2 Influenza viruses in a lentiviral pseudotype production system: Application to pandemic risk assessment

    Professor Shawn Smallman
    Professor, Portland State University, OR, USA
    Title: Biopiracy and vaccines: The new pandemic influenza plan

    Professor Ian Brown
    Head, Avian Virology and Mammalian Influenza, AHVLA, UK
    Title: Strengths and weaknesses of surveillance in the animal sector informing veterinary public health risk

    Professor John Oxford
    Professor of Virology, St Barts & The Royal London QMW, and Scientific Director and President, Retroscreen Virology Ltd
    Title: Infection of volunteers with influenza in quarantine gives insight into transmission and correlates of protection

    Professor Sarah Gilbert
    Professor of Vaccinology, Jenner Institute, Old Road Campus Research Building, Oxford, UK
    Title: MVA-NP+M1: an influenza vaccine with potent immunogenicity in older adults

    Professor Dr Albert DME Osterhaus (Keynote Address)
    Head, Department of Virology, Erasmus MC, The Netherlands
    Title: From zoonosis to pandemic: What next

    Professor Dr Ron Fouchier
    Professor of Molecular Virology, Department of Virology, Erasmus MC, The Netherlands
    Title: Transmission of influenza A/H5N1 virus via aerosol or respiratory droplets between ferrets

    Dr Colin Butter
    Institute for Animal Health, UK
    Title: One Influenza One Vaccine: Towards a universal vaccine for influenza: Protective efficacy of Modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved NP influenza antigens in chickens challenged with low pathogenic avian influenza virus

    Dr Rossella Sgarbanti
    San Raffaele Pisana Scientific Institute for Research, Rome, Italy
    Title: Influenza virus and intracellular redox state: characterization of redox sensitive molecular targets for innovative antiviral strategies

    Miss Dhivya Rajasekaran
    Swinburne University of Technology, Faculty of Life & Social Sciences, Victoria, Australia
    Title: Identification of traditional medicinal plant extracts with novel anti-influenza activity

    Dr Teagan Guarnaccia
    WHO Collaborating Centre for Reference & Research on Influenza, Melbourne, Victoria, Australia
    Title: Antigenic drift of the A(H1N1)pdm09 virus in the ferret model of vaccination and infection

  • Posters Presented at Influenza 2012

    (Presenters in Bold)

    Transmission dynamics of the 2009 H1N1 pandemic in India: The impact of school holidays

    Sheikh Taslim Ali, A S Kadi and Neil M Ferguson

    Molecular differences between avian influenza viruses grown in chicken and duck cells, a comparative study

    Al-Mubarak FT, Daly J, Dunham SP

    Socially indicated variability of the Spanish influenza (1918-1920) sex and age mortality rates

    Nikola Anusic

    Construction of a chicken lung cDNA library and interaction with Highly Pathogenic Avian Influenza (HPAIV) H5N1 Nucleoprotein

    Vinod Rmt Balasubramaniam ; Abdul Rahman Omar; Iekhsan Othman and Sharifah Syed Hassan

    The influenza virus and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed in permissive cells at multiple sites in the human respiratory and gastrointestinal tracts

    Stephanie Bertram, Adeline Heurich, Hayley Lavender, Stefanie Gierer, Simon Danisch, Paula Perin, Jared M Lucas, Elizabeth J Soilleux, Stefan Pöhlmann

    Co-packaging of influenza viral RNAs into virus particles as shown by FISH analysis at single-virus particle resolution

    Yi-ying Chou, Qinshan Gao, Reza Vafabakhsh, Sultan Doğanay, Taekjip Ha and Peter Palese

    TRIM22 restricts Influenza A Virus Infection

    A Di Pietro, A Kajaste-Rudnitski, G Towers, A Oteiza, N Mechti, E Vicenzi

    Genetic drift of HA and NA in Danish swine influenza virus from the period 2003-2012

    Kristina Fobian, Solvej Ø Breum, Charlotte Hjulsager, Ramona Trebbien, Karoline Bragstad, Lars E Larsen

    Influence of D222G mutation in the haemagglutinin (HA) of A(H1N1)pdm09 virus on its transmissibility and pathogenicity in pigs

    F Garcon, SM Brookes, A Nunez, V Coward, R Cordero, D Hicks, T Matrosovich, M Matrosovich, IH Brown

    High-potential transmission of highly-pathogenic form of avian influenza H5N1 in several areas of the Java Region in Indonesia

    Triwibowo Ambar Garjito, Jastal, Mujiyanto, Yusran Udin, Widoretno, Ridwan, Wahyu Purbowasito, Barandi Sapta Widartono, NLPI Dharmayanti, Misriah and Rita Kustriastuti

    Emergence of HPAI from LPAI using the H7N7 HPAI Oxfordshire, UK 2008 outbreak as a model

    Amanda Hanna, Wendy A Howard, Christine Russell, Alejandro Núñez, Wendy S Barclay and Jill Banks

    Pathogenicity of the Egyptian 2008 and 2010 challenge viruses of AI (H5N1)

    Marden NA, Omer LM, El Ebiary EA and HA Hussein

    First reported detection of a low pathogenicity avian influenza virus subtype H9 infection in domestic fowl in England

    Richard M Irvine, C Daniel Parker, Scott M Reid, Allan Ball, William J Cox, Steve C Essen, Amanda Hanna, Marek J Slomka, Ian H Brown

    Scanning surveillance and investigative diagnosis of a mixed APMV-1 and low pathogenicity avian influenza virus infection in a poultry flock in Great Britain

    Richard M Irvine, Scott M Reid, William J Cox, Vanessa Ceeraz, Ruth Manvell, Steve C Essen, Helen Errington, Ian H Brown

    First reported detection of pandemic (H1N1) 2009 virus in turkeys in the United Kingdom

    Richard M Irvine, Scott M Reid, William J Cox, Vanessa Ceeraz, David Sutton, Steve C Essen, Wendy A Howard, Marek J Slomka, Ian H Brown

    Rational design and evaluation of bioshields for the control of avian influenza virus

    Seema Jasim, Mark P Stevens, Anthony A Nash

    Natural infection of Eurasian eagle owls (Bubo bubo) with highly pathogenic avian Influenza in the Republic of Korea

    Woo-Jin Jeon, Young-Jun Kim, Jun-Gu Choi, Kang-Seok Choi, Youn-Jeong Lee, Su-Youn Jung, Kyung-Hyun Lee, Eun-Kyoung Lee, Jun-Hun Kwon

    Isolation of a reassortant H13N2 virus from a mallard fecal sample in South Korea

    Hyun-Mi Kang, Jun-Gu Choi, Min-Chul Kim, Hye-Ryoung Kim, Jae-Ku Oem, You-Chan Bae, Mi-Ra Paek, Jun-Hun Kwon and Youn-Jeong Lee

    Development of reverse –phased HPLC Method for Quantitation of Haemagglutinin in Influenza Vaccine and its correlation with SRID method

    Hyunkyung Kang, Hyemin Song, Seung-Tae Chung, Kwangmoon Lee, Sinjung Kang, Donghee Kim, Min Seok Bae, Yejin Choi, Jeongnam Woo, Chiyoung Ahn

    Knowledge and awareness related to avian influenza (H5N1) among small and medium-sized poultry farm owners in Bangladesh

    Md Sakirul Islam Khan, Sheikh Mohammad Fazle Akbar, Shaikh Tanveer Hossain, Mamun-Al-Mahatab

    In vitro culture of Influenza A virus alters the evolutionary trajectories of viral populations

    N Renzette, P Liu, D Caffrey, K Zeldovich, C Palmiotti, T Spain, J Camolli, J Borenstein, C Schiffer, J Wang, R Finberg and T Kowalik

    Phylodynamic analysis of Influenza virus from structured populations

    Denise Kühnert, Tim Vaughan, Alexei Drummond

    Role of cholesterol in cell susceptibility to 2009 pandemic influenza A virus infection

    Hao-Wei Wang, Chun-Nan Lee, Sui-Yuan Chang and Chuan-Liang Kao

    Diverse reassortment patterns of avian influenza viruses among different subtypes in internal segments

    Lu Lu, Samantha Lycett, Andrew J Leigh Brown

    Phylodynamics and Signatures of Selection in A(H1N1)pdm09 Human Influenza Viruses

    SJ Lycett, JA Hedge, AJ Leigh Brown, A Rambaut

    Retroviral pseudotype-based antibody neutralization assays for the accurate serological profiling of H5N1 clade 2.2 A/chicken/Egypt/1709-1/07 and the antigenic drift variant A/chicken/Egypt/1709-6/08. A case study demonstrating the utility of this assay as a sensitive tool for the study of the antigenic evolution of avian influenza viruses

    Eleonora Molesti, Adelaide Milani, Giovanni Cattoli and Nigel Temperton

    Spatial model of avian influenza risk areas in major cities of Indonesia

    Mujiyanto, Triwibowo AG, Widoretno, Yusran Udin, Jastal, Mohammad Sudomo, Hari Kusnanto, Lutfan Lazuardi

    Pathology of Whooper Swans (Cygnus cygnus) and Chickens Infected with H5N1 Avian Influenza Virus in Akita, Japan in 2008

    Kikuyasu Nakamura, Yu Yamamoto and Manabu Yamada

    Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies

    Shigefumi Okmoto, Takeshi Tanimoto, Ahmad M Haredy, Shin-ichi Tamura, Yoshinobu Okuno, Yasuko Mori , Koichi Yamanishi

    Amino-acid signature L226 in the receptor binding site of the hemagglutinin enhances the replication efficiency of an H9N2 Avian Influenza virus in swine respiratory explants

    Patrono LV, Van Poucke SG, Beato MS, Terregino C, Van Reeth K and Capua I

    Continuous genotypic evolution and antigenic drift of H9N2 influenza viruses in China since 2010

    Juan Pu, Guozhong Zhang, Min Wang, Guanlong Xu, Yandi Wei, Chu Wen, Qian Du, Meng Sun, Wuyun Gaowa, Jinliang Wang, Yipeng Sun, Jinhua Liu

    In vitro antiviral activity of the nasal decongestant xylometazoline

    Michael Robinson, Lori Andrews, Kathryn Vanderlaag, Karen Wolff, Douty Bamba, Kelli Kuhen, Vincent Leonard, Alexandre Rey, Nathalie Hasler-Nguyen

    Deep Panning: Steps Towards Probing the IgOme

    Arie Ryvkin, Haim Ashkenazy, Tal Pupko, Jonathan M Gershoni

    Identification and characterization of different ligands targeting Influenza virus entry

    Schmier S, Haarmann T, Pleschka S, Hust M, Wolff T, Tanasa R, Dietrich U

    Use of equine influenza pseudotyping for serological screening

    Simon Scott, Eleonora Molesti, Nigel Temperton, Janet Daly

    Genetic characterisation of Vietnamese and Nepalese H5N1 highly-pathogenic avian influenza viruses isolated during 2009-2012

    Amanda Hanna, Thanh L To, Hien H Tong, Sahar Mahmood, Wendy Howard, Susan E Collins, Anita S Puranik, Jill Banks, Ian H Brown and Marek J Slomka

    Risk factors for Death from Influenza Pandemic in 1918-19: A Case-Control Study

    Jennifer A Summers, Michael G Baker, James Stanley, Nick Wilson

    Mortality Differences between Australian and New Zealand Soldiers during the 1918-19 Influenza Pandemic

    Jennifer A Summers, Nick Wilson, G Dennis Shanks

    Historical Approaches in Studying Past Influenza Pandemics: The Value of Military Archival Sources

    Jennifer A Summers, Michael G Baker, Nick Wilson

    Compensatory evolution of net-charge in influenza A virus hemagglutini

    Yuki Suzuki and Yoshiyuki Suzuki

    Positive selection for gains of N-linked glycosylation sites in hemagglutinin during evolution of H3N2 human influenza A virus

    Yoshiyuki Suzuki and Yuki Kobayashi

    Down-regulation of importin-α3 levels in the lung correlates with influenza virus systemic spread and pathogenicity in mice

    Swantje Thiele, Debby van Riel, ADME Osterhaus, Gülsah Gabriel

    Broader Neutralizing Antibodies against H5N1 Viruses Using Prime-boost Immunization of Hyperglycosylated Hemagglutinin DNA and Virus-like Particles

    Shih-Chang Lin, Yu-Fen Lin, Pele Chong, Suh-Chin Wu

    Is the drug resistance in swine influenza influenced by epistatic interactions between viral segments?

    Mojca Zelnikar, Samantha J Lycett, Andrew J Leigh-Brown reviews .