Summary of Influenza 2012
One Influenza, One World
11-13 September 2012, St Hilda’s College, Oxford, UK
Influenza2012 addressed basic and applied research on zoonotic and human influenza viruses and covered the following general areas if influenza research:-
- Molecular virology and immunology
- Antiviral drug development and treatment strategies, including vaccination
- Host-pathogen interaction – virulence and pathogenecity
- Epidemiology and evolution
- Mathematical models
- National and international surveillance and contingency strategies
- Advances in viral detection and identification technologies
Distinguished Keynote Speakers
- Prof Robert Webster
- Prof Hans-Dieter Klenk
- Prof ADME Osterhaus
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Distinguished Faculty
Professor Adrian Hill
Jenner Institute, University of Oxford, UK
Professor Dr Hans-Dieter Klenk (Keynote Address)
Professor, Institute of Virology, Philipps University, Marburg, Germany
Title: Determinants of host specificity and pathogenicity of influenza viruses
Professor Dr Thomas C Mettenleiter
Präsident, Friedrich-Loeffler-Institut, Germany
Title: Molecular basis of AIV pathogenicity–polybasic cleavage site revisited
Dr Mikhail Matrosovich
Professor, Institute of Virology, Philipps University, Marburg, Germany
Title: Receptor specificity and interspecies transmission of influenza viruses
Dr Giovanni Maga
Head, DNA Enzymology & Molecular Virology Section, Institute of Molecular Genetics IGM-CNR, National Research Council, Italy
Title: Novel host-pathogen interactions between human proteins and NS1 of epidemic avian influenza virus
Dr Roland Marquet
Research Director, Université de Strasbourg, CNRS IBMC, Strasbourg, France
Title: RNA/RNA interactions and the selective packaging of influenza A genomic segments
Dr Patrick C Reading
NHMRC RD Wright Fellow, Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Title: Glycans on the hemagglutinin of influenza A virus are a target for recognition by soluble and cell-surface C-type lectins
Dr Solvej Ø Breum
Division of Veterinary Diagnostics and Research, Technical University of Denmark,National Veterinary Institute, Copenhagen, Denmark
Title: New influenza A virus reassortments have been found in Danish swine in 2011
Dr Shu-Ming Kuo
Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan
Title: Elongation factor Tu is a host restriction factor in influenza A virus infection
Professor Wendy Barclay
Professor, Imperial College London, UK
Title: Different effects of influenza polymerase mutations in different viruses and in different hosts
Dr Munir Iqbal
Principal Investigator, Avian Influenza Group , Avian Viral Diseases Programme,Institute for Animal Health, Compton, UK
Title: Effect of different glycosylation patterns of the haemagglutinin glycoprotein of H7N1 avian influenza viruses on virus replication and transmission in chickens and turkeys
Professor Robert Webster FRS
Rose Marie Thomas Chair, Division of Virology, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN, USA
Title: Crystallizing the origins of influenza
Dr El-Sayed M Abd El-Whab
Friedrich Loeffler Institute, Germany
Title: Epidemiology and evolution of H5N1 avian influenza virus in Egypt: Lessons learned
Dr Sharon Brookes
Animal Health and Veterinary Laboratories Agency (AHVLA), UK
Title: H9N2 interspecies infection and pandemic preparedness (avian, swine and human)
Dr Marius Gilbert
Universite Libre de Bruxelles, Bruxelles, Belgium
Title: Spatial epidemiology of Highly Pathogenic Avian Influenza H5N1 in poultry: What have we learned?
Dr Mariya V Sivay
Novosibirsk State University, Novosibirsk, Russia
Title: Surveillance for avian influenza viruses in the Western Siberia (Russia), 2008-2011
Miss Jennifer Summers
Department of Public Health, University of Otago, Wellington, New Zealand
Title: Comparison of 1918-19 and 2009 H1N1 influenza pandemics: Epidemiology and lessons learnt
Dr Guillaume Fournié
Veterinary Clinical Sciences Department, Royal Veterinary College, University of London, UK
Title: The potential of live bird markets to maintain and spread avian influenza A (H5N1) virus: a survey of markets in northern Vietnam and Cambodia and mathematical models of transmission
Miss Denise Kuehnert
Department of Computer Science, University of Auckland, New Zealand
Title: Phylodynamic analysis of Influenza virus from structured populations
Dr Nuning Nuraini
Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Indonesia
Title: Simulation for optimal vaccination strategy of bird flu
Dr Laurence Tiley
Senior Lecturer in Molecular Virology, University of Cambridge, UK
Title: Designer chickens for combating avian influenza
Dr Nigel Temperton
Senior Lecturer and Principal Scientist, Viral Pseudotype Unit (VPU), Medway School of Pharmacy, University of Kent, UK
Title: Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies
Dr Francesca Ferrara
Viral Pseudotype Unit (VPU), Medway School of Pharmacy, University of Kent, UK
Title: The human Transmembrane Protease Serine 2 (TMPRSS2) cleaves the haemagglutinins of all Group 2 Influenza viruses in a lentiviral pseudotype production system: Application to pandemic risk assessment
Professor Shawn Smallman
Professor, Portland State University, OR, USA
Title: Biopiracy and vaccines: The new pandemic influenza plan
Professor Ian Brown
Head, Avian Virology and Mammalian Influenza, AHVLA, UK
Title: Strengths and weaknesses of surveillance in the animal sector informing veterinary public health risk
Professor John Oxford
Professor of Virology, St Barts & The Royal London QMW, and Scientific Director and President, Retroscreen Virology Ltd
Title: Infection of volunteers with influenza in quarantine gives insight into transmission and correlates of protection
Professor Sarah Gilbert
Professor of Vaccinology, Jenner Institute, Old Road Campus Research Building, Oxford, UK
Title: MVA-NP+M1: an influenza vaccine with potent immunogenicity in older adults
Professor Dr Albert DME Osterhaus (Keynote Address)
Head, Department of Virology, Erasmus MC, The Netherlands
Title: From zoonosis to pandemic: What next
Professor Dr Ron Fouchier
Professor of Molecular Virology, Department of Virology, Erasmus MC, The Netherlands
Title: Transmission of influenza A/H5N1 virus via aerosol or respiratory droplets between ferrets
Dr Colin Butter
Institute for Animal Health, UK
Title: One Influenza One Vaccine: Towards a universal vaccine for influenza: Protective efficacy of Modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved NP influenza antigens in chickens challenged with low pathogenic avian influenza virus
Dr Rossella Sgarbanti
San Raffaele Pisana Scientific Institute for Research, Rome, Italy
Title: Influenza virus and intracellular redox state: characterization of redox sensitive molecular targets for innovative antiviral strategies
Miss Dhivya Rajasekaran
Swinburne University of Technology, Faculty of Life & Social Sciences, Victoria, Australia
Title: Identification of traditional medicinal plant extracts with novel anti-influenza activity
Dr Teagan Guarnaccia
WHO Collaborating Centre for Reference & Research on Influenza, Melbourne, Victoria, Australia
Title: Antigenic drift of the A(H1N1)pdm09 virus in the ferret model of vaccination and infection
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Posters Presented at Influenza 2012
(Presenters in Bold)
Transmission dynamics of the 2009 H1N1 pandemic in India: The impact of school holidays
Sheikh Taslim Ali, A S Kadi and Neil M Ferguson
Molecular differences between avian influenza viruses grown in chicken and duck cells, a comparative study
Al-Mubarak FT, Daly J, Dunham SP
Socially indicated variability of the Spanish influenza (1918-1920) sex and age mortality rates
Nikola Anusic
Construction of a chicken lung cDNA library and interaction with Highly Pathogenic Avian Influenza (HPAIV) H5N1 Nucleoprotein
Vinod Rmt Balasubramaniam ; Abdul Rahman Omar; Iekhsan Othman and Sharifah Syed Hassan
The influenza virus and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed in permissive cells at multiple sites in the human respiratory and gastrointestinal tracts
Stephanie Bertram, Adeline Heurich, Hayley Lavender, Stefanie Gierer, Simon Danisch, Paula Perin, Jared M Lucas, Elizabeth J Soilleux, Stefan Pöhlmann
Co-packaging of influenza viral RNAs into virus particles as shown by FISH analysis at single-virus particle resolution
Yi-ying Chou, Qinshan Gao, Reza Vafabakhsh, Sultan Doğanay, Taekjip Ha and Peter Palese
TRIM22 restricts Influenza A Virus Infection
A Di Pietro, A Kajaste-Rudnitski, G Towers, A Oteiza, N Mechti, E Vicenzi
Genetic drift of HA and NA in Danish swine influenza virus from the period 2003-2012
Kristina Fobian, Solvej Ø Breum, Charlotte Hjulsager, Ramona Trebbien, Karoline Bragstad, Lars E Larsen
Influence of D222G mutation in the haemagglutinin (HA) of A(H1N1)pdm09 virus on its transmissibility and pathogenicity in pigs
F Garcon, SM Brookes, A Nunez, V Coward, R Cordero, D Hicks, T Matrosovich, M Matrosovich, IH Brown
High-potential transmission of highly-pathogenic form of avian influenza H5N1 in several areas of the Java Region in Indonesia
Triwibowo Ambar Garjito, Jastal, Mujiyanto, Yusran Udin, Widoretno, Ridwan, Wahyu Purbowasito, Barandi Sapta Widartono, NLPI Dharmayanti, Misriah and Rita Kustriastuti
Emergence of HPAI from LPAI using the H7N7 HPAI Oxfordshire, UK 2008 outbreak as a model
Amanda Hanna, Wendy A Howard, Christine Russell, Alejandro Núñez, Wendy S Barclay and Jill Banks
Pathogenicity of the Egyptian 2008 and 2010 challenge viruses of AI (H5N1)
Marden NA, Omer LM, El Ebiary EA and HA Hussein
First reported detection of a low pathogenicity avian influenza virus subtype H9 infection in domestic fowl in England
Richard M Irvine, C Daniel Parker, Scott M Reid, Allan Ball, William J Cox, Steve C Essen, Amanda Hanna, Marek J Slomka, Ian H Brown
Scanning surveillance and investigative diagnosis of a mixed APMV-1 and low pathogenicity avian influenza virus infection in a poultry flock in Great Britain
Richard M Irvine, Scott M Reid, William J Cox, Vanessa Ceeraz, Ruth Manvell, Steve C Essen, Helen Errington, Ian H Brown
First reported detection of pandemic (H1N1) 2009 virus in turkeys in the United Kingdom
Richard M Irvine, Scott M Reid, William J Cox, Vanessa Ceeraz, David Sutton, Steve C Essen, Wendy A Howard, Marek J Slomka, Ian H Brown
Rational design and evaluation of bioshields for the control of avian influenza virus
Seema Jasim, Mark P Stevens, Anthony A Nash
Natural infection of Eurasian eagle owls (Bubo bubo) with highly pathogenic avian Influenza in the Republic of Korea
Woo-Jin Jeon, Young-Jun Kim, Jun-Gu Choi, Kang-Seok Choi, Youn-Jeong Lee, Su-Youn Jung, Kyung-Hyun Lee, Eun-Kyoung Lee, Jun-Hun Kwon
Isolation of a reassortant H13N2 virus from a mallard fecal sample in South Korea
Hyun-Mi Kang, Jun-Gu Choi, Min-Chul Kim, Hye-Ryoung Kim, Jae-Ku Oem, You-Chan Bae, Mi-Ra Paek, Jun-Hun Kwon and Youn-Jeong Lee
Development of reverse –phased HPLC Method for Quantitation of Haemagglutinin in Influenza Vaccine and its correlation with SRID method
Hyunkyung Kang, Hyemin Song, Seung-Tae Chung, Kwangmoon Lee, Sinjung Kang, Donghee Kim, Min Seok Bae, Yejin Choi, Jeongnam Woo, Chiyoung Ahn
Knowledge and awareness related to avian influenza (H5N1) among small and medium-sized poultry farm owners in Bangladesh
Md Sakirul Islam Khan, Sheikh Mohammad Fazle Akbar, Shaikh Tanveer Hossain, Mamun-Al-Mahatab
In vitro culture of Influenza A virus alters the evolutionary trajectories of viral populations
N Renzette, P Liu, D Caffrey, K Zeldovich, C Palmiotti, T Spain, J Camolli, J Borenstein, C Schiffer, J Wang, R Finberg and T Kowalik
Phylodynamic analysis of Influenza virus from structured populations
Denise Kühnert, Tim Vaughan, Alexei Drummond
Role of cholesterol in cell susceptibility to 2009 pandemic influenza A virus infection
Hao-Wei Wang, Chun-Nan Lee, Sui-Yuan Chang and Chuan-Liang Kao
Diverse reassortment patterns of avian influenza viruses among different subtypes in internal segments
Lu Lu, Samantha Lycett, Andrew J Leigh Brown
Phylodynamics and Signatures of Selection in A(H1N1)pdm09 Human Influenza Viruses
SJ Lycett, JA Hedge, AJ Leigh Brown, A Rambaut
Retroviral pseudotype-based antibody neutralization assays for the accurate serological profiling of H5N1 clade 2.2 A/chicken/Egypt/1709-1/07 and the antigenic drift variant A/chicken/Egypt/1709-6/08. A case study demonstrating the utility of this assay as a sensitive tool for the study of the antigenic evolution of avian influenza viruses
Eleonora Molesti, Adelaide Milani, Giovanni Cattoli and Nigel Temperton
Spatial model of avian influenza risk areas in major cities of Indonesia
Mujiyanto, Triwibowo AG, Widoretno, Yusran Udin, Jastal, Mohammad Sudomo, Hari Kusnanto, Lutfan Lazuardi
Pathology of Whooper Swans (Cygnus cygnus) and Chickens Infected with H5N1 Avian Influenza Virus in Akita, Japan in 2008
Kikuyasu Nakamura, Yu Yamamoto and Manabu Yamada
Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies
Shigefumi Okmoto, Takeshi Tanimoto, Ahmad M Haredy, Shin-ichi Tamura, Yoshinobu Okuno, Yasuko Mori , Koichi Yamanishi
Amino-acid signature L226 in the receptor binding site of the hemagglutinin enhances the replication efficiency of an H9N2 Avian Influenza virus in swine respiratory explants
Patrono LV, Van Poucke SG, Beato MS, Terregino C, Van Reeth K and Capua I
Continuous genotypic evolution and antigenic drift of H9N2 influenza viruses in China since 2010
Juan Pu, Guozhong Zhang, Min Wang, Guanlong Xu, Yandi Wei, Chu Wen, Qian Du, Meng Sun, Wuyun Gaowa, Jinliang Wang, Yipeng Sun, Jinhua Liu
In vitro antiviral activity of the nasal decongestant xylometazoline
Michael Robinson, Lori Andrews, Kathryn Vanderlaag, Karen Wolff, Douty Bamba, Kelli Kuhen, Vincent Leonard, Alexandre Rey, Nathalie Hasler-Nguyen
Deep Panning: Steps Towards Probing the IgOme
Arie Ryvkin, Haim Ashkenazy, Tal Pupko, Jonathan M Gershoni
Identification and characterization of different ligands targeting Influenza virus entry
Schmier S, Haarmann T, Pleschka S, Hust M, Wolff T, Tanasa R, Dietrich U
Use of equine influenza pseudotyping for serological screening
Simon Scott, Eleonora Molesti, Nigel Temperton, Janet Daly
Genetic characterisation of Vietnamese and Nepalese H5N1 highly-pathogenic avian influenza viruses isolated during 2009-2012
Amanda Hanna, Thanh L To, Hien H Tong, Sahar Mahmood, Wendy Howard, Susan E Collins, Anita S Puranik, Jill Banks, Ian H Brown and Marek J Slomka
Risk factors for Death from Influenza Pandemic in 1918-19: A Case-Control Study
Jennifer A Summers, Michael G Baker, James Stanley, Nick Wilson
Mortality Differences between Australian and New Zealand Soldiers during the 1918-19 Influenza Pandemic
Jennifer A Summers, Nick Wilson, G Dennis Shanks
Historical Approaches in Studying Past Influenza Pandemics: The Value of Military Archival Sources
Jennifer A Summers, Michael G Baker, Nick Wilson
Compensatory evolution of net-charge in influenza A virus hemagglutini
Yuki Suzuki and Yoshiyuki Suzuki
Positive selection for gains of N-linked glycosylation sites in hemagglutinin during evolution of H3N2 human influenza A virus
Yoshiyuki Suzuki and Yuki Kobayashi
Down-regulation of importin-α3 levels in the lung correlates with influenza virus systemic spread and pathogenicity in mice
Swantje Thiele, Debby van Riel, ADME Osterhaus, Gülsah Gabriel
Broader Neutralizing Antibodies against H5N1 Viruses Using Prime-boost Immunization of Hyperglycosylated Hemagglutinin DNA and Virus-like Particles
Shih-Chang Lin, Yu-Fen Lin, Pele Chong, Suh-Chin Wu
Is the drug resistance in swine influenza influenced by epistatic interactions between viral segments?
Mojca Zelnikar, Samantha J Lycett, Andrew J Leigh-Brown
