Please note the following speaker identities, presentation sequence, sessions and dates are not final and may change.
Session 1: Natural toxins and drug discovery
26th September AM
Session Chairs/Organisers: Glenn King | Yara Cury | Ray Norton
Rationalizing Toxinology with Species-specific Biology: Fish-hunting Cone Snails and other Conoideans
Baldomero M Olivera (Plenary)
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah, 84112 USA
Bunodosine 391 (BDS 391) – a novel sea anemone compound that induces peripheral analgesia mediated by 5-HT3 and TRPV1 ion channels
Wilson A. Ferreira Jr.1, Elisangela Bressan4, Luiza G.C. Nascimento1, André J. Zaharenko2, Gisele Picolo1, KatsuhiroKonno5, Peter W. Reeh4, Yara Cury1
1Laboratory of Pain and Signaling, and 2Laboratory of Genetics, Butantan Institute, 1500 Vital Brazil Av., São Paulo, Brazil
3Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194 Japan
4Dept of Physiology & Pathophysiology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany
Potassium channel blocking toxins as treatments for autoimmune diseases: design, synthesis, stability & delivery
Raymond S Norton
Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia
Venoms to drugs: spider-venom peptides for the treatment of chronic pain and epilepsy
Glenn F King
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
Neuroprotective mechanisms of Losac in B27-deprived cortical neurons involve the expression of monocarboxilate transporter 2
Miryam P Alvarez-Flores1,2, Audrey Hebert1, Ana M. Chudzinski-Tavassi2,3, Luc Pellerin1
1Department of Physiology, University of Lausanne, Lausanne, Switzerland
2Center of Toxins, Immune Response and Cell Signaling-CeTICS, Instituto Butantan, São Paulo, Brazil
3Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil
Snake venom phospholipase A2 as a novel dual acting modulator of human F508del-CFTR and regulator of the prokaryotic pentameric proton-gated ion channel
Grazyna Faure1, Frederick Saul2, Maciej Ostrowski1,3, Maria Stankiewicz4, Pierre-Jean Corringer1, Aleksander Edelman5
1Unité Récepteurs – Canaux, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris, France
2Plate-Forme de Cristallographie, Institut Pasteur, Paris, France
3Nicolaus Copernicus University, Department of Biochemistry, Torun, Poland
4Nicolaus Copernicus University, Faculty of Biology and Environmental Protection, Torun, Poland
5Université Paris Descartes, INSERM U1151, INEM, Paris, France
Prediction of immunogenicity: an in silico approach applied to the recombinant protein Amblyomin-X, a promising antitumor agent
Bárbara Athayde Vaz Galvão da Silva, Ana Marisa Chudzinski Tavassi and Kerly Fernanda Mesquita Pasqualoto
Biochemistry and Biophysics Laboratory, Butantan Institute, São Paulo – SP, Brazil
Venom analytics for discovery of peptide biopharmaceutical candidates
Marija Mladic1, Janaki Iyer2, Reka Otvos1, Martine J Smit3, Wilfried M A Niessen1, Richard Lewis4, Govert W Somsen2, Manjunatha R Kini3 and Jeroen Kool1
1Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
2Protein Science Lab, Dept of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
3Div of Med Chem, Amsterdam Inst for Molecules Medicines & Systems, VU Univ Amsterdam, Amsterdam, The Netherlands
4The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4072, Australia
Mambaquaretin, a green mamba toxin as a new therapeutic agent for polycystic kydney diseases
Justyna Ciolek, 1 Helen Reinfrank , 2 Denis Servent, 1 Gilles Mourier, 1 Bernard Mouillac,3 Loic Quinton,4 Christiane Mendre,3 Ralph Witzgall, 2 Nicolas Gilles1
1CEA-Saclay iBiTecS Gif-sur-Yvette France
2IMCA university Regensburg Germany
3CNRS Montpellier France
4Dépt de Chimie- GIGA Liège Belgium
A novel antitumor protein from Calloselasma rhodostoma venom
Kiem X Trinh1, Khanh B. Nguyen1, Francis S Markland, Jr2, Steve Swenson2, Radu Minea2
1Professor of Vietnam Society on Toxicology (VST), Vietnam
2Keck School of Medicine, Univ of Southern California and USC/Norris Comprehensive Cancer Center, USA
Session 2: Toxins and their derivatives in clinical use or in development
26th September PM
Session Chairs/Organisers: Baldomero (Toto) Olivera | Carl-W Vogel
Molecular basis for the therapeutic efficacy of botulinum neurotoxins and new recombinant variants (Plenary)
J Oliver Dolly1, Jianghui Meng1,2, Thomas Zurawski1, Laura Casals-Diaz1,2, Gary Lawrence1, Ahmed Al-Sabi1, Charles Metais1 and Jiafu Wang1
1International Centre for Neurotherapeutics, Faculty of Science and Health, Dublin City University, Dublin, Ireland
2Present address: Charles Institute of Translational Dermatology, University College Dublin, Dublin, Ireland
Ant venom as a source of bioinsecticide and antimicrobial drug leads
Samira R. Aili1, Axel Touchard2, Matthew P. Padula4, Alain Dejean3, Jérôme Orivel3, Pierre Escoubas2, Graham M. Nicholson1
1Neurotoxin Research Group, School of Life Sciences, University of Technology Sydney, Australia
2VenomeTech, 473 Route des Dolines, Valbonne, France
3CNRS, UMR Ecologie des Forêts de Guyane (EcoFoG), 97379 Kourou Cedex, France
4Proteomics Core Facility, Faculty of Science, University of Technology Sydney, Australia
Exploitation of spider venom peptide toxins for the development of novel molluscicides
Elaine C. Fitches1,2, Michelle Powell2, Katherine Robinson2 , Prashant Pyati1, J.A. Gatehouse1
1School of Biological and Biomedical Sciences, Durham Univ, Durham DH1 3LE, United Kingdom
2Food and Environment Research Agency, Sand Hutton, York YO41 1LZ
Rational Design of a Snake Venom Derived Anti-invasive Agent: A Novel Recombinant Disintegrin as Cancer Therapeutic
Francis S Markland1, Steven Swenson1, Radu Minea2
1Dept of Biochem & Mol Biol, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
2Department of NeuroSurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Synthesis and biological characterization of insecticidal toxin LaIT2, a two-domain peptide isolated from the Liocheles australasiae scorpion venom
Masahiro Miyashita, Ryo Ando, Takafumi Ishido, Yoshiaki Nakagawa and Hisashi Miyagawa
Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
Ion Channel Activity and Neurotoxicity of Jaburetox in Insect Models
Célia R Carlini1,2
1Brain Institute – Inst do Cérebro (InsCer), Pontifícia Univ Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
2Deptt of Biophysics and Center of Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Analgesic and side-effects in rodents of Phα1β a spider venom toxin calcium channel blocker
Marcus V. Gomez1, Celio J. Castro Jr.1, Alessandra H. Souza2, Flavia K. Rigo3, Marta N. Cordeiro4, Danuza M. Diniz1, Claudio A. Silva Jr.1, N. Binda3, Elizete M. R. Pereira3. Juliana F. Silva3and J. Ferreira5
1Medicine and Biomedicine, Inst of Education and Res, Grupo Santa Casa de Belo Horizonte, Belo Horizonte/MG, Brazil
2Graduate Program in Genetics and Applied Toxicology, Lutheran University of Brazil, Canoas/RS, Brazil
3Institute of Education and Research, Grupo Santa Casa de Belo Horizonte, MG, Brazil
4Department of Biochemistry, Ezequiel Dias Foundation, Belo Horizonte, MG, Brazil
5Department of Pharmacology, Biological Sciences Centre, Federal University of Santa Catarina, SC, Brazil
Session 3: Proteomics, venomics, antivenomics
28th September AM
Session Organisers/Chairs: Juan Calvete | Bruno Lomonte
The bright future of venomics
Juan J Calvete1, Davinia Pla1, Libia Sanz1, Jordi Durban1, Alicia Pérez1, Yania Rodríguez1, José Maria Gutiérrez2, Bruno Lomonte2
1Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain
2Instituto Clodomiro Picado, Facultad de Microbiología, Univ de Costa Rica, San José, Costa Rica
‘Toxicovenomics’ – towards an integrative view of compositional and functional aspects of snake venoms
Bruno Lomonte
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
Venom variation, taxon-specific toxins and biological roles of venoms
Stephen P Mackessy
School of Biological Sciences, University of Northern Colorado, Greeley, CO 80639-0017 USA
Making antivenoms for the developing world: is there a place for high quality venomic and antivenomic technologies?
David J Williams1,2, Davinia Pla3, Christine E Wright1, Simon D Jensen1,2, Owen K Paiva2, David A. Warrell4, Juan J Calvete3, José-María Gutiérrez5
1Australian Venom Res Unit, Dept of Pharmacology & Therapeutics, University of Melbourne, Parkville, VIC, Australia
2Charles Campbell Toxinology Centre, University of Papua New Guinea, Port Moresby, NCD, Papua New Guinea
3Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, 46010 Valencia, Spain
4Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
5Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
VenomZone: a new web-portal to unravel venom complexity
Florence Jungo1, Edouard de Castro1, Lydie Bougueleret1, Ioannis Xenarios1,2, Sylvain Poux1
1Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland
2Vital-IT Group, SIB Swiss Institute of Bioinformatics, Quartier Sorge – Bâtiment Génopode, 1015, Lausanne, Switzerland
High-throughput sequencing of toxins with pharmacological interest: proof of concept and first applications
Julien Echterbille1, Michel Degueldre1, Madeleine Boulanger1, Nicolas Gilles2, Loïc Quinton1, Edwin De Pauw1
1Laboratory of Mass Spectrometry – GIGA-R- University of Liege – Belgium
2CEA- IBiTecS, SIMOPRO- Gif Sur Yvette – France
Pushing the limits – Integrating Top-down mass spectrometry into snake venomics
Daniel Petras1, Roderich D Süssmuth1 and Juan J Calvete2
1Technische Universität Berlin, Institut für Chemie, Berlin, Germany2Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain
Session 4: Genomics and transcriptomics
28th September PM
Session Chairs/Organisers: Rob Harrison | Nick Casewell
The Neuromuscular Junction: a primary site of attack of protein neurotoxins
Cesare MONTECUCCO (Plenary)
Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, 35121 Padova, Italy
Genomic and transcriptomic insights in to the origin and evolution of snake venom toxin genes
Nicholas R. Casewell1, Inacio L. Junqueira-de-Azevedo2, Michael K. Richardson3, Robert A. Harrison1, Jacobo Reyes-Velasco4, Todd A. Castoe4, Freek J. Vonk5
1Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
2Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Instituto Butantan, São Paulo, Brazil
3Institute of Biology Leiden (IBL), Leiden University, 2333 BE, Leiden, The Netherlands
4Department of Biology, University of Texas at Arlington, Arlington, USA
5Naturalis Biodiversity Center, 2333 CR, Leiden, The Netherlands
What can we learn from snake genomics?
Michael K. Richardson1, R. Manjunatha Kini2, Nicholas Casewell3, Harald M. E. Kerkkamp1,4 and Freek J. Vonk4
1Institute of Biology, Leiden University, 2333BE Leiden, The Netherlands
2Department of Biological Science, National University of Singapore, Singapore
3Alistair Reid Venom Research Unit Liverpool School of Tropical Medicine, UK
4Naturalis Center for Biodiversity, Leiden, The Netherlands
Transcriptional activation of venom gland-specific genes by epithelium specific ETS transcription factor ESE-3 homolog in Protobothrops flavoviridis snake venom gland
Hitomi Nakamura1, Tatsuo Murakami2, Shosaku Hattori3, Yoshiyuki Sakaki4, Takatoshi Ohkuri1, Takahito Chijiwa2, Motonori Ohno2, Naoko Oda-Ueda1
1Dept of Pharma Sciences, Faculty of Pharmaceutical Sciences, Sojo University, Ikeda, Nishi-ku, Kumamoto, Japan
2Dept of Applied Life Science, Faculty of Bioscience and Biotechnology, Sojo University, Ikeda, Nishi-ku, Kumamoto, Japan
3Institute of Medical Science, University of Tokyo, Oshima-gun, Kagoshima 894-1531, Japan
4Genomic Sciences Center, RIKEN, 1-7-22 Suehiro-chou, Tsurumi-ku, Yokohama 230-0045, Japan
Characterizing venom composition in the enigmatic genus Aspidelaps: genes, proteins and pathology
Gareth Whiteley1, Rhiannon A. E. Logan1, Kam-Yin D. Leung1, Juan J. Calvete3, Davinia Pla3 Nicholas R. Casewell1, Simon C. Wagstaff2, Robert A. Harrison1
1Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
2Bioinformatics Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
3Lab de Venómica Estructural y Funcional Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, 46010 Valencia, Spain
Using venom to acquire complete venom protein cDNA sequences and assemble partial venom gland transcriptomes
Cassandra M. Modahl and Stephen P. Mackessy
University of Northern Colorado, School of Biological Sciences, Colorado, USA
Venom glands transcriptomics
Sergey Kozlov and Eugene Grishin
Shemyakin-Ovchinnikov Inst of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, Moscow, Russia
First insights about comparative Bumblebees high-throughput transcriptomes and proteomes
Marion Verdenaud1, Michel Degueldre2, Garikoitz Legarda3, Miguel Cabo3, Raquel Rodriguez3, Edwin De Pauw2, Loic Quinton2, Rebeca Minambres3, Frederic Ducancel4
1iBiTEc-S/SPI, CEA, Gif-sur-Yvette, France.
2Laboratory of mass spectrometry, Department of Chemistry, ULg, Liege, Belgium
3Sistemas Genomicos Ltd, Valencia, Spain
4IMETI/SIV, CEA, Fontenay-aux-Roses, France
A large scale survey of toxin and toxin-like genes in transcriptomes reveals the molecular tool-kit of scorpion venom evolution
Ricardo C Rodríguez de la Vega1, David Morgenstern2, Tatiana Giraud1
1Univeristy Paris-Sud/CNRS; Lab Ecologie, Systématique, Evolution; Equipe Génétique et Ecologie Evolutives; Orsay, FRANCE
2New York University, Proteomics Resource Center, Langone Medical Center, New York, NY, USA
Session 5: Ion channel toxins
29th September AM
Session Chairs/Organisers: Eddie Rowan | Jan Tytgat | Isabel Bermudez-Diaz
DNA sequencing … and other applications of pore-forming toxins
Hagan Bayley (Plenary)
Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK
Spider peptide neurotoxins as positive allosteric modulators of insect nicotinic acetylcholine receptors
Monique J Windley and Graham M Nicholson
Neurotoxin Res Group, School of Medical & Molecular Biosciences, University of Technology Sydney, NSW 2007, Australia
The folding of an ion channel revealed by toxin binding
Neil V Marrion
School of Physiology & Pharmacology, Medical and Veterinary Sciences, University of Bristol, Bristol, UK
Use of concatamers to identify and map the binding site of pharmacologically active compounds on Cys-loop ligand-gated ion channels
Isabel Bermudez-Diaz
Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK
What are nicotinic acetylcholine receptor blockers in venoms of Viperidae snakes?
Yuri N. Utkin1, Ekaterina A. Vulfius2, Igor E. Kasheverov1, Vladislav G. Starkov1, Alexey V. Osipov1, Tatyana V. Andreeva1, Victor I. Tsetlin1
1Shemyakin-Ovchinnikov Inst of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia
2Institute of Cell Biophysics, Russian Academy of Sciences, Ul. Institutskaya 3, Pushchino, Moscow Region, Russia
What’s common between animal toxins and plant defence peptides?
Alexander A Vassilevski
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Micrurotoxins MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity
Jean-Pierre Rosso1,#, Jürgen R. Schwarz2,#, Marcelo Diaz-Bustamante3,#, Brigitte Céard1, José María Gutiérrez4, Matthias Kneussel2, Olaf Pongs5, Frank Bosmans6, 7, Pierre E Bougis1
1Aix Marseille Université, CNRS, CRN2M UMR7286, 13344, Marseille, France
2Institute of Molecular Neurogenetics, ZMNH, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany
3Lieber Institute for Brain Development, Johns Hopkins University – School of Medicine, Baltimore, MD 21205 USA
4Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San Jose, Costa Rica
5Institut für Physiologie, Universität des Saarlandes, 66424, Homburg, Germany
6Department of Physiology, Johns Hopkins University – School of Medicine, Baltimore, MD 21205, USA
7Solomon H. Snyder Dept of Neuroscience, Johns Hopkins University – School of Medicine, Baltimore, MD 21205, USA
Defensins, a novel kind of potassium channel inhibitors
Yingliang Wu
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
Three-finger toxic and non-toxic proteins, old and new tools for research on neuroreceptors
Victor I Tsetlin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
Session 6: Conotoxins and other pain-inducing toxins
29th September PM
Session Chairs/Organisers: Richard Lewis | Sebastien Dutertre | Sulan Luo
Using animal toxins to explore neurological diseases: where would we be without them?
Angela Vincent (Plenary)
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK
Evolution of new function in conotoxins
Richard J Lewis
IMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia
Novel insights into cone snail venom-ecology relationships
Sébastien Dutertre
Inst des Biomolécules Max Mousseron, UMR 5247, Univ Montpellier – CNRS, Montpellier, France
A new Hainan Conotoxin Potently Blocks α9α10 Nicotinic Acetylcholine Receptors
Sulan Luo1, Dongting Zhangsun1, Peta J. Harvey2, Quentin Kaas2, Yong Wu1, Xiaopeng Zhu1, Yuanyan Hu1, Xiaodan Li1, Victor Tsetlin3，Melissa McIntyre4, Cheryl Dowell4, James C. Baxter5, Keith S Elmslie5, David J. Craik2, and J. Michael McIntosh4
1Key Lab of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou Hainan, China
2Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072 Australia
3Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
4George E. Wahlen Veterans Affairs Medical Center & Depts of Biology and Psychiatry, Univ of Utah, Salt Lake City, UT, USA
5Department of Pharmacology, Kirksville College of Osteopathic Medicine, AT Still University, Kirksville, MO, USA
Inhibition of acid-sensing ion channel 1a by a novel double-knot spider toxin provides neuroprotection after stroke with a large therapeutic window
Irène R Chassagnon1, Yanni Chin1, Sandy S Pineda1, Mehdi Mobli2, Claudia McCarthy3, Robert E Widdop3, Lachlan D Rash1, Glenn F King1
1Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
2Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD 4072, Australia
3Department of Pharmacology, Monash University, Clayton, VIC 3800, Australia
Cono-RFamide from Conus textile modulates proton-activated ASIC3 currents and alters sensory neuron excitability
Catharina Reimers1, Hubert Kalbacher2, Yuemin Tian1, Stefan Stevanović3, Silke Kauferstein4, Dietrich Mebs4, Stefan Gründer1
1Institute of Physiology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany
2Interfaculty Institute for Biochemistry, Medical & Natural Sciences Research Center, Univ of Tübingen, Tübingen, Germany
3Department of Immunology, Institute for Cell Biology, University of Tübingen, 72076 Tübingen, Germany
4Institute of Legal Medicine, University of Frankfurt, 60596 Frankfurt, Germany
Naja atra venom peptide selectively blocks voltage-gated sodium channel Nav1.8 to abolish pain
Fan Zhang, Zhonghua Liu, Songping Liang
College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
When cone snails and spiders meet: design of selective and potent cyclized sodium channel inhibitors
Steve Peigneur1, Christina I. Schroeder2, Mohitosh Maiti3, Eveline Lescrinier3, Piet Herdewyn3, David J. Craik2, Jan Tytgat1
1Toxicology and Pharmacology, University of Leuven (KU Leuven), Campus Gasthuisberg, Herestraat, Leuven, Belgium
2Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia
3Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium
Rational design and synthesis of a novel NaV1.8 selective inhibitor
Christina I. Schroeder1, Jennifer Deuis1,2, Zoltan Dekan1, Sónia Troeira Henriques1, David J. Craik1, Paul F. Alewood1, Richard J. Lewis1 and Irina Vetter1,2
1Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia
2School of Pharmacy, University of Queensland, Woolloongabba, Queensland, 4102, Australia
Session 7: Snake venom metalloproteinases, phospholipases and other toxins mediating inflammation
30th September AM
Session Chairs/Organisers: Jay Fox | José María Gutiérrez | Ana Maria Moura de Silva
Oxygen sensing in animals: the new physiology of hypoxia
Peter J Ratcliffe (Plenary)
Henry Wellcome Building for Molecular Physiology, University of Oxford, UK
Correlating Snake Envenomation Mechanisms and Pathophysiology with Wound Exudate Proteomics Over Time and Space
Jessica K. A. Macêdo1,2, Alexandra Rucavado3, Teresa Escalante3, José M. Gutiérrez3, Jay W. Fox1
1University of Virginia School of Medicine, Charlottesville, VA 22908, USA
2Brazilian Center for Protein Research, Department of Cell Biology, University of Brasilia, Brasilia/DF, Brazil
3Instituto Clodomiro Picado, School of Microbiology, University of Costa Rica, San José, Costa Rica
Understanding the mechanisms of microvascular damage induced by snake venom hemorrhagic metalloproteinases
José María Gutiérrez1, Cristina Herrera1,2, Teresa Escalante1, Mathieu-Benoit Voisin3, Erika Camacho1, Sussan Nourshargh3, Jay W. Fox4, Alexandra Rucavado1
1Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
2Facultad de Farmacia, Universidad de Costa Rica, San José, Costa Rica
3William Harvey Res Inst, Barts & The London School of Medicine and Dentistry, Queen Mary Univ of London, London, UK
4University of Virginia School of Medicine, Charlottesville, VA, USA
Protein disulphide isomerase in the retrograde cell transport of ammodytoxin and the structurally related mammalian secreted phospholipases A2
Igor Križaj1,2, Jernej Oberčkal1, Lidija Kovačič1, Adrijana Leonardi1, Jernej Šribar1
1Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia
2Dept of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia
Animal presynaptic neurotoxins provide a relevant model of motor axon terminal degeneration followed by regeneration
Michela Rigoni1, Elisa Duregotti1, Samuele Negro1, Michele Scorzeto1, Irene Zornetta1, Bryan C. Dickinson2,3, Chris J. Chang2,3, and Cesare Montecucco1,4
1Department of Biomedical Sciences, University of Padua, Padua 35131, Italy
2Department of Chemistry and Molecular and Cell Biology, and
3Howard Hughes Medical Institute, University of California, Berkeley, CA, USA
4Italian National Research Council Institute of Neuroscience, Padua 35131, Italy
Structural determinants of the interaction between snake venom metallopeptidase and its natural inhibitors
Ana G C Neves-Ferreira1 ; Surza L G Rocha1; Viviane A Bastos1; Francisco Gomes-Neto1; Eladio O F Sanchez2; Teresa Escalante3; Alexandra Rucavado3; Richard H Valente1; Jonas Perales1
1Laboratório de Toxinologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil
2Centro de Pesquisa e Desenvolvimento, Instituto Ezequiel Dias, Belo Horizonte, Brazil
3Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
Bothrops lanceolatus venom: Potential mechanisms involved in envenoming
Marie Delafontaine1, 2, Isadora M. Villas Boas1, Laurence Mathieu2, Joël Blomet2, Denise V. Tambourgi1
1Immunochemistry Laboratory, Butantan Institute, Av. Prof. Vital Brazil, São Paulo, Brazil
2Prevor Laboratory, Moulin de Verville, 95760 Valmondois, France
Session 8: Antivenom-1: Innovation and commercialisation
26th September AM
Session Chairs/Organisers: José María Gutiérrez | Philippe Billiald
Improving the distribution of antivenoms through a knowledge-based approach: a neglected aspect of innovation
José María Gutiérrez
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
An update on the use of antibodies against envenomings
Philippe Billiald1, Larissa M. Alvarenga1,2, Matthieu Juste3, Julien Muzard1, Nicolas Aubrey3, Juliana De Moura2
1University Paris-Sud & MNHN-CNRS UMR7245, Paris, France
2Laboratorio de Imunoquimica, Departamento de Patologia Basica, Universidade Federal do Parana, Curitiba, PR, Brazil
3Université de Tours-INRA UMR 1282, 31 Avenue Monge, Tours, 37042, France
Cost-effectiveness of Antivenoms for Snakebite Envenoming in 16 countries in West Africa
Abdulrazaq G Habib1, Andreas Kuznik1, Hamza Muhammad1, Maryam I Abdullahi1, Mohammed Lamorde2, Jean-Philippe Chippaux3, David A Warrell4
1Venom Antivenom Research Group (VASP), College of Health of Sciences, Bayero University, Kano, Nigeria
2Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda
3Institute de Recherche Pour Le Development, Cotonou, Benin Republic
4Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK
Approaches to improve the snake-species, dose and local tissue-necrosis efficacy of snakebite treatment: Next Generation Snakebite Therapies
Robert A Harrison1, Camilla M Renjifo1, Ullrich Wernery2, Simon C Wagstaff1, Nicholas R Casewell1
1Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
2Central Veterinary Research Laboratory, Dubai, United Arab Emirates
Papua New Guinea’s innovative Snakebite Research & Training Project: an international collaboration for sustainable change
David J Williams1,2
1Australian Venom Res Unit, Department of Pharmacology and Therapeutics, Univ of Melbourne, Parkville, VIC, Australia
2Charles Campbell Toxinology Centre, School of Medicine & Health Sciences, Univ of Papua New Guinea, Papua New Guinea
Reducing costs in antivenom production: present and future
Jorge Kalil
Instituto Butantan, Av. Vital Brasil, 1500, Butantã, 05503-900, São Paulo/SP, Brazil
The future of antivenoms: Oligoclonal mixtures of recombinant, human(ized) antibodies
Andreas H Laustsen
Dept of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Neutralization of Snake Venom Myotoxins with a Chemically-Modified DNA Aptamer: An Approach to the Development of a Universal Antivenom
Elda E. Sánchez1,2, Montamas Suntravat1, Sara E. Lucena1, Curtis Lam3, Nancy Ward3, Mark Shumbera3, David Gorenstein3, Peter Davies4
1National Natural Toxins Research Center, Texas A&M University-Kingsville, Kingsville, Texas USA
2Department of Chemistry, Texas A&M University-Kingsville, Kingsville, Texas USA
3AM Biotechnologies, LLC, Houston, Texas, USA
4Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA
Session 9: Antivenom-2: Pre-clinical and clinical assessment
26th September PM
Session Chairs/Organisers: David Williams | David Lalloo | Fan Hui Wen
Clinical trials of a new Papuan taipan antivenom in Papua New Guinea: opportunities, challenges and rewards
David J Williams1,2
1Australian Venom Res Unit, Department of Pharmacology and Therapeutics, Univ of Melbourne, Parkville, VIC, Australia
2Charles Campbell Toxinology Centre, School of Medicine & Health Sciences, Univ of Papua New Guinea, Papua New Guinea
Clinical evaluation of interventions in envenoming; the challenges
David G Lalloo
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA
Evidence versus experience; an antivenom dilemma
Julian White and Scott A Weinstein
Department of Toxinology, Women’s and Children’s Hospital, North Adelaide, South Australia
Refinement of the WHO-recommended preclinical tests of antivenom efficacy
Fiona M S Bolton and Robert A Harrison
Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
The development of a new polyspecific antivenom for snake envenoming in Sri Lanka: A new model of international research collaboration
Dan E Keyler1,2, Indika Gawarammana3, Mauren Villalta4, Guillermo León4, Kolitha H Sellahewa5, Kim McWhorter1, Roy Malleappah1, Scott A Weistein6, José María Gutiérrez4
1Animal Venom Research International (AVRI), California, USA
2Department of Experimental and Clinical Pharmacology, University of Minnesota, USA
3Department of Medicine and South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Sri Lanka
4Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica
5Former Chairman of the Snakebite Committee of Sri Lanka Medical Association, Sri Lanka
6Women’s and Children’s Hospital, Adelaide, Australia
Engineered antibody fragments for the detection, quantification and neutralization of Loxosceles intermedia toxins
Larissa M Alvarenga1, Nicolas Aubrey2, Sabrina K Silva1, Carlos C Olortegui3, Juliana De Moura1, Philippe Billiald4
1Lab de Imunoquimica, Departamento de Patologia Basica, Universidade Federal do Parana, Curitiba CEP, PR, Brazil
2Université de Tours-INRA UMR 1282, 31 Avenue Monge, Tours, 37042, France
3Dept de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Univ Federal de Minas Gerais, Belo Horizonte, MG, Brazil
4Muséum National d’Histoire Naturelle, UMR MNHN-CNRS 7245, 12 rue Buffon, Paris, 75231, France
A prospective, multicenter, double-blind, randomized, controlled, clinical trial comparing Crotalinae Equine Immune F(ab’)2 and Crotalidae Polyvalent Immune Fab (ovine) for the treatment of US Crotalinae envenomation
Sean P Bush6, Anne-Michelle Ruha1, Steven A Seifert5, David L Morgan8, Brandon J Lewis9, Thomas C Arnold10, Richard F Clark13, William J Meggs6, Eric A Toschlog6, Stephen Borron14, John Haynes14, Gary R Figge11, Dawn R Sollee12, Farshad M Shirazi7, Robert Wolk2, Dan Quan3, Walter Garcia-Ubbelohde4, Leslie V Boyer7
1Banner Good Samaritan Medical Center, Phoenix AZ, USA
2Tucson Medical Center, Tucson AZ, USA
3Maricopa Medical Center, Phoenix AZ, USA
4Instituto Bioclon, Mexico Distrito Federal, Mexico
5University of New Mexico Health Sciences Center, Albuquerque NM, USA
6Brody School of Medicine, Greenville NC, USA
7University of Arizona Health Sciences Center, Tucson AZ, USA
8Scott and White Memorial Hospital, Temple TX, USA
9Saint Joseph’s Hospital, College Station TX, USA
10Louisiana State University Health Sciences Center, Shreveport LA, USA
11Northwest Medical Center, Tucson AZ, USA
12University of Florida Health, Jacksonville FL, USA
13University of California San Diego Medical Center, San Diego CA, USA
14West Texas Poison Control Center, El Paso TX, USA
Session 10: Clinical-1: Snake-bites
28th September AM
Session Chairs/Organisers: Julian White | Steve Seifert
Far From Home: The Challenges of Non-Native Snake Envenomations
Steven A Seifert
University of New Mexico School of Medicine, New Mexico Poison Center, Albuquerque, NM, USA
Clinical evaluation of the 20 Minute Whole Blood Clotting Test (20WBCT) and reliability at different temperatures and types of glassware
Owen K Paiva1, Benjamin Bande1, Roseanne Power1, David J Williams1,2
1Australian Venom Res Unit, Department of Pharmacology and Therapeutics, Univ of Melbourne, Parkville, VIC, Australia
2Charles Campbell Toxinology Centre, School of Medicine & Health Sciences, Univ of Papua New Guinea, Papua New Guinea
Snakebites in Lao PDR: Community-based surveys disclose high incidence of an invisible public health problem
Inthanomchanh Vongphoumy1, Panom Phongmany1, Sengdao Sydala1, Nouda Prasith1, Ralf Reintjes3, Joerg Blessmann1,2
1Provincial Health Department Savannakhet, Lao PDR,
2Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
3Hamburg University of Applied Science, Hamburg, Germany
The Public Health Burden of Snakebite Envenoming in 16 Countries in West Africa
Abdulrazaq G Habib1, Andreas Kuznik1, Mohammed Lamorde2, Basheer A Chedi1, Isa S Abubakar1, Muhammad Y Gwarzo1, Jean-Philippe Chippaux3, David A Warrell4
1Venom Antivenom Res Group (VASP), College of Health of Sciences, Bayero University, Kano, Nigeria
2Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda
3Institute de Recherche Pour Le Development, Cotonou, Benin Republic
4Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK
Development and assessment of a brief psychological intervention for snakebite victims
Chamara Wijesinghe1, SS Williams1, A Kasturiratne1, N Dolawatta2, AKGP Wimalaratne2, B Wijewickrema1, SF Jayamanne1,3, GK Isbister3, A Dawson3, DG Lalloo4, HJ de Silva1
1Faculty of Medicine, University of Kelaniya, Ragama, and
2General Hospital, Polonnaruwa, Sri Lanka
3South Asian Clinical Toxicology Research Collaboration, and
4Liverpool School of Tropical Medicine, UK
Space, time and species trends in snake envenomation in the south of Vietnam 1997 – 2012
Phuong L Hoang1, Quyen K Le1, Nhan T Ho2, Trieu H Phan2, Ngan Nguyen1, Hung Q Le1, Binh Q Tran1, Jeremy N Day2, 3
1Department of Tropical Medicine,, Cho Ray Hospital, 201B Nguyễn Chí Thanh, Phường 12, Hồ Chí Minh, Vietnam
2Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet, Quan 5, Viet Nam
3Nuffield Department of Medicine, University of Oxford, Wellington Square, Oxford OX1 1AA, UK
A pharmacological approach to snakebite first aid
Dirk F van Helden1, Margaret A O’Leary2,3, Megan E Saul4, Paul A Thomas5, Peter J Dosen1, Ian M Whyte2,3, Sally A McFadden6, Geoff K Isbister2,3
1School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
2Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, NSW 2298, Australia
3School of Medicine and Public Health, University of Newcastle, Callaghan, NSW 2308, Australia
4Department of Nuclear Medicine, John Hunter Hospital, New Lambton, NSW 2305, Australia
5Department of Nuclear Medicine, Royal Brisbane and Women’s Hospital, Herston, QLD 4006, Australia
6School of Psychology, University of Newcastle, Callaghan, NSW 2308, Australia
Session 11: Clinical-2: Arthropod bites and stings
28th September PM
Session Chairs/Organisers: Fábio Bucaretchi | Rick Dart
Scorpion stings in Brazil
Fábio Bucaretchi1,2, Eduardo M De Capitani1,3, Stephen Hyslop1,4
1Campinas Poison Control Center, Faculty of Medical Sciences, State Univ of Campinas (UNICAMP), Campinas, SP, Brazil
2Department of Pediatrics, Faculty of Medical Sciences, State Univ of Campinas (UNICAMP), Campinas, Brazil
3Department of Clinical Medicine, Faculty of Medical Sciences, State Univ of Campinas (UNICAMP), Campinas, Brazil
4Department of Pharmacology, Faculty of Medical Sciences, State Univ of Campinas (UNICAMP), Campinas, Brazil
Efficacy of F(ab)2 Antivenom for the Treatment of Latrodectus mactans Envenoming in the United States
Victoria E Anderson1, Richard C Dart,1,2 for the Latrodectus antivenom study investigators
1Rocky Mountain Poison and Drug Center – Denver Health, Denver, CO, USA
2University of Colorado School of Medicine, Aurora, CO, USA
Severe neurotoxic scorpion envenoming (Parabuthus leiosoma) in East Africa
David A Warrell,1 David M Silverstein,2 Mauro Saio,2 Sean Dundas,3 Nigel Dundas3
1Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DW, UK
2Nairobi Hospital, Nairobi, Kenya
3Sean Dundas Safaris, Karen, Nairobi, Kenya
Hospitalisations and deaths due to venomous bites and stings in Australia from 2000 to 2013
Ronelle E Welton1, David J Williams1 and Danny Liew2
1Australian Venom Research Unit, Dept of Pharmacology and Therapeutics, Univ of Melbourne, Victoria, Australia
2Centre for Clinical Epidemiol, Biostatistics & Health Services Res, The Univ of Melbourne & Melbourne Health, Victoria, Australia
Use of emergency transport by patients with envenomation injury in Queensland, Australia: a retrospective longitudinal study from 2007 to 2014
Ronelle Welton1, John Rathbone2, Danny Liew3, David Williams1
1Australian Venom Res Unit, Dept of Pharmacology and Therapeutics, Univ of Melbourne, Victoria, Australia
2Queensland Ambulance Service, Australia3Centre for Clinical Epidemiol, Biostatistics & Health Services Res, The Univ of Melbourne & Melbourne Health, Victoria, Australia
“VAPAGuide – The free access Emergency Guide to Venomous and Poisonous Animals”
Mauro Bodio1 and Thomas Junghanss2
1Swiss Tropical & Public Health Institute, Basle, Switzerland
2Section Clinical Tropical Medicine, University Hospital, Heidelberg, Germany
Session 12: Discovering new toxins in unexpected taxa mammals, amphibians, annelids, crustaceans, ticks
29th September AM
Session Chairs/Organisers: Christopher Shaw | Bryan Fry | Pat Nuttall
Anorexigenic peptides in amphibian skin: unexpected or not?
Chris Shaw
School of Pharmacy, Queen’s University Belfast, UK
Ticks and toxins
Pat Nuttall
University of Oxford, Department of Zoology, The Tinbergen Building, South Parks Road, Oxford, UK
Evolution of venom toxins in bloodworms (Annelida: Polychaeta)
Lahcen I Campbell1, Bjoern M von Reumont1, Eivind A B Undheim2, 3, Sandy Richter4, Christoph Bleidorn4, 5, Ronald A Jenner1
1Department of Life Sciences, Natural History Museum, Cromwell Road, SW7 5BD London, UK
2Division of Chemistry and Structural Biology, Inst for Molecular Bioscience, The Univ of Queensland, Brisbane, Australia
3Venom Evolution Laboratory, School of Biological Sciences, The University of Queensland, St. Lucia, Brisbane, Australia
4Molecular Evolution and Systematics of Animals, Institute of Biology, University of Leipzig, Germany
5German Centre for Integrative Biodiversity Research (iDiv) Halle-Jane-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany
Novel natural and designed cholinergic ligands: the possibilities of fundamental and practical applications
Igor Kasheverov1, Denis Kudryavtsev1, Irina Shelukhina1, Igor Ivanov1, Valentin Stonik2, Yuri Utkin1, Anton Chugunov1, Roman Efremov1
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
2Pacific Institute of Bioorganic Chemistry RAS, Vladivostok, Russia
Pipa carvalhoi and Rhinella jimi: The non-peptidic anurans skin secretions
Douglas O C Mariano1, Hugo Vigerelli1, Juliana M Sciani1, Eduardo R Alves2, Carlos A G S Jared2, Marta M Antoniazzi2, Lydia F Yamaguchi3, Massuo J Kato3, Graciane M M Caporale4, Andréa C R da Silva4, Daniel C Pimenta1
1Laboratório de Bioquímica e Biofísica, and
2Laboratório de Biologia Celular, Instituto Butantan, São Paulo, Brazil
3Instituto de Química, Universidade de São Paulo, São Paulo, Brazil
4Laboratório de Sorologia, Instituto Pasteur, São Paulo, Brazil
Analysis of α-Glycerotoxin (GLTx) expression refines the view of the venom system in glycerid annelids
Sandy Richter1, Frédéric A Meunier2, Conrad Helm1, Lars Hering3, Stephan H Drukewitz1, Nico Fuhrmann1, Lahcen I Campbell4, Ronald A Jenner4, Giampietro Schiavo5, and Christoph Bleidorn1,6
1Molecular Evolution and Systematics of Animals, Institute of Biology, University of Leipzig, Germany
2Neuronal Trafficking Laboratory, Queensland Brain Institute, The University of Queensland, Australia
3Animal Evolution & Development, Institute of Biology, University of Leipzig, Germany
4Department of Life Sciences, The Natural History Museum, London, UK
5Sobell Dept of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London, UK
6German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany
The genes of the Antarctic heteronemertine Parborlasia corrugatus coding for toxic parborlysins
Matej Butala1, Daniel Šega1, Blaž Tomc1, Adrijana Leonardi2, Igor Križaj2,3,4, Frithjof C. Kuepper5 and Tom Turk1
1University of Ljubljana; Biotechnical Faculty; Department of Biology; 1000 Ljubljana; Slovenia
2Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
3Dept of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, Univ of Ljubljana, Ljubljana, Slovenia
4Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, 1000 Ljubljana, Slovenia
5Chair in Marine Biodiversity, Oceanlab, University of Aberdeen, Main Street, Newburgh AB41 6AA, Scotland, UK
Nicotinic Receptor Targeted Drug Design with a Nemertine Toxin
William Kem, Hong Xing and Ferenc Soti
Dept of Pharmacology & Therapeutics, Univ of Florida College of Medicine, 12oo Newell Drive, Gainesville, FL, USA
Dark Venomics: transcriptomics, proteomics and morphology enlight the first venomous crustacean, cave dwelling Remipedia
Björn M von Reumont1,2, Eivind Undheim3, Ronald A Jenner3
1Center of molecular Biodiversity, Research Museum Alexander Koenig, Bonn, Germany
2Department of Life Sciences, Natural History Museum, London, United Kingdom
3Center for Advanced Imaging, University of Queensland, Australia
Toad toxins and poisonous snakes: the bufadienolide universe and its mechanism of action with Na+/K+-ATPase
Holger Scheib1, Kim Roelants2, Kevin Messenger3,4, Bryan G Fry1,5
1Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia
2Amphibian Evolution Lab, Biology Department, Vrije Universiteit Brussel, Pleinlaan 2, Brussels B-1050, Belgium
3Alabama A & M University, Dept of Biological & Environmental Sciences, 4900 Meridian Street North, Normal, AL, USA
4Nanjing Forestry University, Department of Biology and Environmental Science, Nanjing, Jiangsu, China
5Institute for Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia
Session 13: Toxins in natural history and evolution
29th September PM
Session Chair/Organiser: Wolfgang Wüster
Snakes behaving badly: evolution of venom spitting in cobras in its historical context
Wolfgang Wüster1, Nicholas R. Casewell2, Robert A. Harrison2, Cara Hall1, Adam Heap1 and Harry W. Greene3
1Bangor University, School of Biological Sciences, Environment Centre Wales, Bangor LL57 2UW, UK
2Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
3Cornell University, Department of Ecology and Evolutionary Biology, E251 Corson Hall, Ithaca, NY 14853, USA
Extreme convergence in toxin resistance by predictable parallel molecular evolution
Beata Ujvari1,2, Nicholas R. Casewell3, Kartik Sunagar4, Kevin Arbuckle5, Wolfgang Wüster6, Nathan Lo7, Denis O’Meally8, Christa Beckmann1, Glenn F. King9, Evelyne Deplazes9, Thomas Madsen1,10,11
1Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin Univ, Geelong, Victoria 3216, Australia
2Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
3Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
4Dept of Ecology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
5Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK
6School of Biological Sciences, Bangor University, Bangor, LL57 2UW, UK
7School of Biological Sciences, University of Sydney, NSW 2006, Australia
8Institute for Applied Ecology, University of Canberra, ACT 2601, Australia
9Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
10School of Molecular Biosciences, University of Sydney, NSW 2006, Australia
11School of Biological Sciences, University of Wollongong, NSW 2522, Australia
The rise and fall of an evolutionary innovation
Kartik Sunagar and Yehu Moran
Dept of Ecology, The Alexander Silberman Institute for Life Sciences. Hebrew Univ of Jerusalem, Jerusalem, Israel
Limitations on a biochemical arsenal — do centipede venoms evolve under morphological constraint?
Eivind A.B. Undheim1,2, Brett R. Hamilton4, Nyoman Kurniawan2, Greg Bowlay4, Darren L. Brown1, Carsten H.G. Müller5, Andy Sombke5, Bronwen Cribb3, David Merritt3, Jenny L. Stow1, Deon J. Venter4,6, Bryan G. Fry3, and Glenn F. King1
1Institute for Molecular Bioscience, 2Centre for Advanced Imaging, and 3School of Biological Sciences, The University of Queensland, St. Lucia, QLD, Australia
4OMICS, Pathology Department, Mater Health Services, South Brisbane, QLD, Australia
5Ernst-Moritz-Arndt-Universität Greifswald, Zoologisches Institut und Museum, Greifswald, Germany
7School of Medicine, The University of Queensland, St. Lucia, QLD, Australia
Fluctuations of toxin levels in a chemically defended amphibian
Gary M. Bucciarelli1, H. Bradley Shaffer1, David B. Green2, Lee B. Kats2
1Department of Ecology and Evolutionary Biology, University California, Los Angeles, California USA
2Natural Sciences Division, Pepperdine University, Malibu, California, USA
Ontogenetic shifts in the diet of Pseudonaja sp. are paralleled by ontogenetic shifts in venom
Timothy N W Jackson, Bryan G Fry
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia
The dynamic diversification of the reptile venom system
Bryan G Fry
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia QLD, 4072 Australia
It’s Not Easy Being Mean: Consequences of Chemical Antipredator Defence for Ecology, Evolution, and Conservation
Kevin Arbuckle
Institute of Integrative Biology, Biosciences Building, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
Session 14: Venoms as an emerging evolutionary model
30th September AM
Session Chair/Organiser: Juan Calvete
Using The Molecular Diversity of Terebrid Snail Venom To Investigate Gene Evolution and Adaptive Change
Mandë Holford1,2
1Dept of Chemistry and Biochemistry, Hunter College Belfer Research Building and CUNY Graduate Center, NY, USA
2The American Museum of Natural History, NY, NY 10024, USA
Evolutionary diversity of sea anemone venom
Marymegan Daly and Jason Macrander
Department of Evolution, Ecology & Organismal Biology, The Ohio State University, Columbus OH USA
Tracking toxins in neglected venomous invertebrates
Ronald A Jenner1, Lahcen I Campbell1, Bjoern M von Reumont1, Christoph Bleidorn2, 3, Eivind A B Undheim4, 5
1Department of Life Sciences, Natural History Museum, Cromwell Road, SW7 5BD London, UK
2Molecular Evolution and Systematics of Animals, Institute of Biology, University of Leipzig, Germany
3German Centre for Integrative Biodiversity Research (iDiv) Halle-Jane-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany
4Division of Chemistry & Structural Biology, Institute for Molecular Bioscience, The Univ of Queensland, Brisbane, Australia
5Venom Evolution Laboratory, School of Biological Sciences, The University of Queensland, St. Lucia, Brisbane, Australia
Expression of venom gene homologs in diverse python tissues: a new model for the evolution of snake venom and a re-assessment of transcriptome-based definition of venoms
Jacobo Reyes-Velasco1, Daren C. Card1, Audra L. Andrew1, Kyle J. Shaney1, Richard H. Adams1, Drew R. Schield1, Nicholas R. Casewell2, Stephen P. Mackessy3, and Todd A. Castoe1
1Department of Biology, University of Texas at Arlington, USA
2Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
3School of Biological Sciences, University of Northern Colorado, Greeley, CO USA
Mechanisms of toxin evolution evaluated using the Phospholipase A2 gene family from pitvipers
Anita Malhotra1, Simon Creer1, Roger S Thorpe1, Reto Stöcklin2, John B Harris3
1School of Biological Sciences, College of Natural Sciences, Bangor University, Bangor, Gwynedd LL58 8NN, UK
2Atheris Laboratories, Case Postale 314, CH-1233 Bernex-Geneva, Switzerland
3School of Neurology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
Evidence for the Presence of an Endogenous Venom-Resistance Molecule in a Local Population of Deer Mouse (Peromyscus maniculatus)
Thomas M McCabe and Stephen P Mackessy
School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA
Session 15: Marine and freshwater algal and dinoflagellate toxins
28th September AM
Session Chair/Organiser: Brett Neilan
Saxitoxin: a trans-kingdom sodium channel-blocking purine alkaloid
Brett A Neilan1 and Ralf Kellmann2
1School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia
2Hormone Lab, Haukeland University Hospital and Department of Molecular Biology, University of Bergen, Bergen, Norway
Toxicological profiles of new palytoxins, a world wide problem for human health
Aurelia Tubaro and Marco Pelin
University of Trieste, Department of Life Science, Trieste, Italy
Characterization of the voltage-gated sodium channel in Crassostrea gigas: its sensitivity to paralytic shellfish toxins produced by Alexandrium minutum
Floriane Boullot1, Evelyne Benoit2, Justine Castrec1, Hélène Hégaret1, Pierre Boudry3, Philippe Soudant1 and Caroline Fabioux1
1UMR 6539 (CNRS/UBO/IRD/Ifremer), Inst Universitaire Européen de la Mer, rue Dumont d’Urville, 29280 Plouzané, France
2Neuro-PSI, Institut des Neurosciences Paris-Saclay, UMR 9197, CNRS, Bât. 32-33, and Service d’Ingénierie Moléculaire des Protéines (DSV/iBiTec-S/SIMOPRO), CEA de Saclay, Bât. 152, 91190 Gif sur Yvette, France
3Ifremer, UMR 6539 (CNRS/UBO/IRD/Ifremer), Centre de Bretagne, ZI de la Pointe du Diable, CS 10070, Plouzané, France
Xanthophyll Glycosides from Cyanobacteria are Teratogenic Pro-Retinoids with Potential Implications to Global Declines in Aquatic Vertebrates
Asha Jaja-Chimedza1, Miroslav Gantar2, Patrick D. L. Gibbs3, Michael C. Schmale3 and John P. Berry1
1Dept of Chemistry and Biochemistry, Florida International University, 3000 NE 151st Street, North Miami, FL 33181, USA
2Dept of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA3Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL, USA
Ciguatera: recent advances but the risk remains
Richard J Lewis
Institute for Molecular Bioscience, The University of Queensland, 4072, Australia
Session 16: Toxins and the haemostatic system
28th September PM
Session Chairs/Organisers: Manjunatha Kini | Kenneth Clemetson
Fasxiator: a Novel, Highly Specific Factor XIa Inhibitor from Krait Venom
R Manjunatha Kini
Dept of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 119260, Singapore
Toxins and their effects on platelets
Kenneth J. Clemetson
Haemostasis Research, Dept of Haematology, Dept Clinical Res, University of Bern, Inselspital, Bern, Switzerland
Phospholipids role on Amblyomin-X selectivity for tumor cells and on its antihemostatic activity
Ana Marisa Chudzinski-Tavassi1, Katia Morais1, Vania Goulart Branco1, Asif Iqbal1, Sonia Aparecida de Andrade1, Kerly F. M. Pasqualoto1, Evandro L. Duarte2, Maria Teresa Lamy2
1Laboratory of Biochemistry and Biophysics, Butantan Institute, Sao Paulo, SP, Brazil
2Institute of Physics, University of São Paulo, SP, Brazil
Regulation of expression of venom prothrombin activators
Xia Han1, Shiyang Kwong1, Rouwen Ge1, Prasanna Kolatkar2, and R Manjunatha Kini1
1Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
2Qatar Biomedical Research Institute, 5825, Doha, Qatar
Potential biomedical application of Kunitz-type protease inhibitors from Daboia russelii russelii venom
Ashis K Mukherjee1,2, Sumita Dutta1, Bhargab Kalita1, Stephen P Mackessy2
1,2Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India
2School of Biological Sciences, University of Northern Colorado, Greeley, COCO80639-0017, USA
Characterization and Molecular Cloning of Antithrombotic Activity of Nemopilema nomurai Jellyfish Venom
Seong kyeong Bae1, Young Chul Kwon1, Seungshic Yum2, Won Duk Yoon4 and Euikyung Kim1
1Dept of Pharmacology and Toxicology, College of Veterinary Medicine, Gyeongsang National University, Republic of Korea
2South Sea Research Institute, Korea Institute of Ocean Science and Technology (KIOST), Geoje, Republic of Korea
3Ballast Water Research Center, Korea Institute of Ocean Science and Technology (KIOST), Geoje, Republic of Korea
4Headquarters for Marine Environment, National Fisheries Research & Development Inst, Gijang-gun, Republic of Korea
Thrombin inhibitors from hematophagous animals
Janaki Krishnamoorthy Iyer and R Manjunatha Kini
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
Session 17: Biotoxins and bioterrorism
29th September AM
Session Chairs/Organisers: Daniel Gillet | P Gopalakrishnakone
Progress toward Developing a Safe and Efficacious Ricin Vaccine
Leonard A Smith
Office of Chief Scientist (HQ), U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
Inhibitors of Ricin and Shigatoxin Intracellular Trafficking Treat Mice with O104:H4 STEC Infection
Neetu Gupta1, Romain Noël2, Aurélien Michau1, Karen Hinsinger2, Valérie Pons2, Ayaka Shima3, Thomas Secher3, Daniela Garcia-Castillo4, Ludger Johannes4, Eric Oswald3, Jean-Christophe Cintrat2, Julien Barbier1, Daniel Gillet1
1SIMOPRO, Inst of Biology & Technology of Saclay, Atomic and Alternative Energies Commission, France – Team 11 Lermit
2SCBM, Institute of Biology & Technology of Saclay, Atomic and Alternative Energies Commission, France – Team 12 Lermit
3Inserm, UMR1043, CPTP, Toulouse, France
4Traffic, Signaling and Delivery, Curie Institute, 75005, Paris, France
Detection of Venoms and Toxins
P Gopalakrishnakone
Venom and Toxin Research Programme, Department of Anatomy, National University of Singapore, NUHS, Singapore
Chemical Weapons with Biological Toxins origin
Mahdi Balali-Mood
Medical Toxicology Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Exploring the toxinome of Staphylococcus aureus using targeted proteomics
Benoit Gilquin1,2,3, Florence Couzon4,5,6,7,8,9, Michel Jaquinod1,2,3, Mathilde Louwagie1,2,3, Myriam Ferro1,2,3, François Vandenesch4,5,6,7,8,9, Virginie Brun1,2,3
1University Grenoble Alpes, iRTSV-BGE, Grenoble, France
2CEA, iRTSV-BGE, Grenoble, France
3INSERM, BGE, Grenoble, France
4International Center for Infectiology Research, Université de Lyon, Lyon, France
5INSERM U1111, Lyon, France
6Ecole Normale Supérieure de Lyon, Lyon, France
7Université Lyon 1, Lyon, France
8CNRS, UMR5308, Lyon, France
9Hospices Civils de Lyon, Centre National de Référence des Staphylocoques, Lyon, France
Functional Characterization of a Novel Botulinum Neurotoxin Hybrid
Suzanne R. Kalb1 Jakub Baudys1, William H. Tepp2, Chistina Pier2, Sabine Pellett2, Brian H. Raphael1, Janet K. Dykes1, Carolina Lúquez1, Eric A. Johnson2, Susan E. Maslanka1, and John R. Barr1
1Centers for Disease Control and Prevention, Atlanta, GA, USA
2University of Wisconsin-Madison, Madison, WI, USA
Session 18: Advances in the understanding of bacterial and fungal toxins
29th September PM
(Including the ISN Symposium on “Medically-important bacterial neurotoxins affecting the nervous system”)
Session Chairs/Organisers: Cesare Montecucco | Len Smith
Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway
Marina de Bernard
Department of Biology, University of Padua, Padua, Italy
The new word of hundreds of different Botulinum Neurotoxins
Ornella Rossetto1, Marco Pirazzini1, Domenico Azarnia Tehran1, Giulia Zanetti1, Thomas Binz3, Clifford C. Shone4, Cesare Montecucco1,2
1Department of Biomedical Science University of Padova, Italy
2CNR Institute of Neuroscience, University of Padova, Italy
3Institut fur Biochemie, Medizinische Hochschule Germany
4Health Protection Agency, UK
The journey of tetanus and botulinum neurotoxins in the CNS
Giampietro Schiavo, Kinga Bercsenyi, Nathalie Schmieg J. Barney Bryson, Martin Wallace, Paola Caccin, Matthew Golding, Giuseppe Zanotti, Linda Greensmith, Roswitha Nischt
Sobell Dept of Motor Neuroscience & Movement Disorders, UCL-Inst of Neurology, University College London, London, UK
13,19-didesmethyl and 13-desmethyl spirolide-C neurotoxic actions are mainly due to interactions with nicotinic rather than muscarinic receptors
Rómulo Aráoz1,2, Gilles Ouanounou1, Bogdan I. Iorga3, Amélie Goudet2, Doria Alili2, Muriel Amar2, Evelyne Benoit1,2, Denis Servent2, Jordi Molgó1,2
1CNRS, Institut des Neurosciences Paris-Saclay, UMR 9197, 91190 Gif-sur-Yvette, France
2CEA, Service d’Ingénierie Moléculaire des Protéines (DSV/iBiTec-S/SIMOPRO), 91191 Gif-sur-Yvette, France
3CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198 Gif sur Yvette Cedex, France
New complexities of μ-Conotoxin actions are seen in their inhibition of “simple” prokaryotic sodium channels
Rocio K. Finol-Urdaneta1,2,3, Cristina Arrigoni4, Sun Huang1, Robert Glavica1, Denis McMaster1, Jeff R. McArthur1,3, Daniel Minor4, Robert J. French1
1Dept of Physiology & Pharmacology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
2MS 008 Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA
3Dept. of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
4Cardiovascular Res Inst, California Institute for Quantitative Biomedical Research, Univ of California, San Francisco, CA, USA
Session 19: Venom and toxin pharmacology
30th September AM
Session Chairs/Organisers: Denis Servent | Christine Wright
Aminergic Toxins interacting with GPCRs: Identification, pharmacological characterization, structural and engineering studies
Guillaume Blanchet, Arhamatoulaye Maïga, Gilles Mourier, Bernard Gilquin, Nicolas Gilles and Denis Servent
CEA, Institute of Biology and Technology (iBiTecS), Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), France
The cardiovascular pharmacology of the venom of the Papuan black snake Pseudechis papuanus
Christine E Wright1,2 and Makhala M Khammy1
1Cardiovascular Therapeutics Unit, Dept of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia
2Australian Venom Research Unit, Dept of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia
Using atomic force microscopy to characterise the mechanism of action of two antimicrobial peptides from the venom of Scorpio maurus palmatus
Patrick L Harrison1, G. Heath2, Abdel-Rahman M A1 3, SD Evens3, K. Miller1 & PN Strong1
1Biomedical Research Centre, Sheffield Hallam University, 1 Howard Street, Sheffield, S1 1WB, UK
2Department of Physics and Astronomy, Leeds University, Woodhouse Lane, Leeds, LS2 9JT, UK3Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt
Cytoskeleton participation on crotalfine-induced antinociception in inflammatory pain
Luciene M. Zanchetta1, Ana Carolina Almeida1, Vanessa Gutierrez1, Vanessa Zambelli1, Gisele Picolo1, Sandra Vessoni2, Marinilce Santos3, Yara Cury1
1LEDS, Instituto Butantan, USP, São Paulo, Brasil
2Fisiopatologia, Instituto Butantan, USP, São Paulo, Brasil
3Ciências Biomédicas, USP, São Paulo, Brasil
Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays
Fernanda C Cardoso, Volker Herzig, Glenn F King and Richard J Lewis
Institute for Molecular Bioscience, Queensland Bioscience Precinct, The University of Queensland, Brisbane, QLD, AU, 4072
Sudden cardiovascular collapse in snakebite: differing mechanisms of hypotension with a venom PLA2 compared to a prothrombin activator
Janeyuth Chaisakul1, 5, Geoffrey K. Isbister1, 2, Margaret A. O’Leary2, Helena C. Parkington3, Marianne Tare3, Sanjaya Kuruppu4, and Wayne C. Hodgson1
1Monash Venom Group, Department of Pharmacology, Monash University, VIC, 3800, Australia
2Department of Clinical Pharmacology and Toxicology, Calvary Mater, NSW, 2298, Australia
3Department of Physiology, Monash University, VIC, 3800, Australia
4Department of Biochemistry and Molecular Biology, Monash University, VIC, 3800, Australia
5Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand
Assessment of neurotoxic activity of an isolated toxin from Tityus bahiensis scorpion venom intrahippocampally injected in rats
Lucas A Freitas1, Alexandre K Kuniyoshi2, Daniela C Carvalho2, Aline V Auada3, Maria Eliza F V Paulo1, Ana Claudia M Sobral1, Ivo Lebrun3, Jorge C Flório4, Fernanda C V Portaro2, Valquiria A C Dorce1, Ana L A Nencioni1
1Laboratory of Pharmacology, Butantan Institute, São Paulo, Brazil
2Laboratory of Immunochemistry, Butantan Institute, São Paulo, Brazil
3Laboratory of Biochemistry, Butantan Institute, São Paulo, Brazil
4Departament of Pathology, Faculty of Veterinary Medicine and Zootechny, USP, São Paulo, Brazil
Session 20: Plant and mushroom poisoning
(This session is partially sponsored by the International Society on Toxinology)
30th September AM
Session Chairs/Organisers: Michael Eddleston | Julian White
Epidemiology and management of plant self-poisoning in South Asia
Michael Eddleston1,2
1Pharmacology, Toxicology & Therapeutics, University of Edinburgh, Edinburgh, UK
2National Poisons Information Service – Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
Mushroom poisoning: a proposed new clinical classification
Julian White1, Scott Weinstein1, Luc De Haro2, Regis Bédry3, Andreas Schaper4, Barry Rumack5, Thomas Zilker6
1Toxinology Dept., Women’s & Children’s Hospital, North Adelaide, Australia
2Marseille Poison Centre, Hopital Sainte Marguerite, Marseille, France
3Hospital Secure Unit, Pellegrin University Hospital, Bordeaux, France
4GIZ-Nord Poisons Centre, University Medical Center Göettingen, Göttingen, Germany
5University of Colorado School of Medicine, Aurora, Colorado, USA
6Dept for Clinical Toxicology at II, Med. Klinik, TU München, Munich, Germany
Challenges of diagnosis of fatal plant related acute intoxication in Bangladesh
M Abul Faiz1, Ariful Bashar2, Aniruddha Ghose3, Robed Amin4, Abdullah Abu Sayeed5, Quazi Tarikul Islam6
1Dev Care Foundation & Former Director General of Health Services, Dhanmondhi Residential Area, Dhaka, Bangladesh
2SK Hospital Mymenshing, Bangladesh 3Chittagong Medical College, Chittagong, Bangladesh 4Dhaka Medical College, Dhaka, Bangladesh5Rangunia Upazila Health Complex, Rangunia, Chittagong, Bangladesh6Popular Medical College, Dhaka, Bangladesh
Management of Amanita poisoning
Thomas R Zilker
Toxicological Department II.Med. Clinic Klinikum rechts der Isar (MRI) Technical University Munich (TUM), Germany
The ”new” mushroom syndromes
Régis Bédry
Hospital Interregional secured Unit, University Hospital Pellegrin, Place Amélie-Raba-Léon, 33000 Bordeaux, France
Session 21: Marine and freshwater stings and venoms
29th September AM
Session Chair/Organiser: David Warrell
Lethal factor and mechanism of the venom from Jellyfish Nemopilema nomurai (Stomolophus meleagris)
Rongfeng Li1, Huahua Yu1, Yang Yue1,2 and Pengcheng Li1
1Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
2University of Chinese Academy of Sciences, Beijing, 100039, China
State-of-the-art transgenic, genomic and microscopic approaches for characterizing venom and toxin producing cells in sea anemones
Yaara Shenkar, Kartik Sunagar and Yehu Moran
Dept of Ecology, Evolution & Behavior, Alexander Silberman Life Sci Inst, The Hebrew Univ of Jerusalem, Jerusalem, Israel
The lionfish in the New World: dissemination, ecological impact and risks to humans
Vidal Haddad Junior
Department of Dermatology, Botucatu Medical School, São Paulo State, Brazil
Unravelling the venom complexity of the jellyfish Chrysaora fuscescens (Cnidaria, Scyphozoa) by an integrated transcriptome and proteome approach
Dalia Ponce1, 2, Diane L. Brinkman3, Karen Luna-Ramírez1, Jeremy Potriquet4, Christine E. Wright1, 2, Jason Mulvenna4
1Australian Venom Research Unit, Department of Pharmacology and Therapeutics, Univ of Melbourne, Victoria, Australia
2Cardiovascular Therapeutics Unit, Dept of Pharmacology and Therapeutics, Univ of Melbourne, Victoria, Australia
3Australian Institute of Marine Science, P. M. B. No 3, Townsville Mail Centre, Townsville, Queensland, Australia
4QIMR Berghofer MRI, Infectious Diseases Program, Brisbane, Queensland, Australia
Cubozoan Envenomations: Pathogenetic Mechanisms and Clinical Management Implications
Angel A Yanagihara
Department of Tropical Medicine, John A. Burns School of Medicine, Univ of Hawaii at Manoa, Honolulu HI, USA
Presence of tetrodotoxin in an increasing number of vectors, and the real value of TEF (toxic equivalent factor)
Luis M Botana
Dept Pharmacology, Fac. Veterinary, University of Santiago de Compostela, Campus Lugo, 27002 Spain
Session 22: Clinical snake-bite cases
29th September 2015 PM
Session Chair/Organiser: David Warrell
**This session will start at 13.30hr**
Coral snake (Micrurus spp.) bites in Brazil: A review of literature reports over the last 147 years
Fábio Bucaretchi1,2, Eduardo M De Capitani1,3, Cinthia K Rodrigues4, Marlene Zannin4,5, Nelson J da SIlva Jr6, José Y Risk7, Luciana L Casais e Silva8, Stephen Hyslop1,9
1Campinas Poison Control Center, Faculty of Medical Sciences, State Univ of Campinas (UNICAMP), Campinas, SP, Brazil
2Dept of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil
3Dept of Clinical Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil
4Santa Catarina Poison Control Center, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil
5Department of Pathology, Health Science Center, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil
6Department of Biology, Pontifical Catholic University of Goiás, Goiânia, GO, Brazil
7Hospital Vital Brazil, Institute Butantan, São Paulo, SP, Brazil
8Institute of Health Sciences, Federal University of Bahia (UFBA), Salvador, BA, Brazil
9Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil
An instructive case of presumed brown snake (Pseudonaja spp.) envenoming
Judy Ou1, Adrian Foran1, Julian White2, Scott A Weinstein2
1Flinders Medical Centre, Bedford Park, Adelaide, South Australia
2Department of Toxinology, Women’s and Children’s Hospital, 72 King William St, North Adelaide, South Australia
The clinical presentation of an Aruban rattlesnake bite is comparable with bites by snakes belonging to the Crotalus durissus complex
Marieke A Dijkman1, Dorien E M Damhuis2, Irma de Vrie 1, Jan Meulenbelt1,3,4
1Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht, the Netherlands
2Emergency Department, Ziekenhuisgroep Twente (ZGT), Almelo, the Netherlands
3Department of Intensive Care Medicine, University Medical Centre Utrecht, the Netherlands
4Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands
Morbidity and Mortality Related to Capillary Leak Syndrome In Daboia russelli Bite
Joseph K Joseph1, Jaideep C Menon2, Manoj P Jose3, Pradip P Kendre4
1Senior Consultant Physician And Nephrologist, Little Flower Hospital And Research Centre, Angamaly, Kochi, Kerala, India
2Senior Cardiologist, MAGJ Hospital, Mookkannoor, Kochi, Kerala, India
3Senior consultant physician Little Flower Hospital And Research Centre, Angamaly, Kochi, Kerala, India
4Senior Resident, Little Flower Hospital And Research Centre Angamaly, Kochi, Kerala, India
“Size Does Matter”
Trevor S Cook1, Don Merrill1, Gus A Gross1,2, Katherine Lee1, Elizabeth Fun1, Jackie Bibby1, Christopher S Hall2
1Palacios Community Medical Center, Palacios, Texas, USA
2Matagorda Regional Medical Center, Bay City, Texas, USA
Epidemiology of Snakebites in Angola
Paula R Oliveira1, Arnaldo González2
1University Lueji A’Nkonde Malanje, Angola
2Research and Information of Drugs and Toxicology Center, Malanje, Angola
Snakebites in rural northern Bihar, India – A one year, prospective study on snakebite epidemiology and risk factors for bad outcomes
Lois Armstrong,1 Taka Longkumer1, Vishal Santra2, Philip Finny1
1Duncan Hospital, Raxaul, East Champaran District, Bihar, India
2Simultala Conservationists, Nalikul, Hooghly, West Bengal, India
Russell’s Viper (Daboia Russelii): A Newly Recognized Cause of Neuro-Myo-Renal toxic envenomation in Bangladesh
Aniruddha Ghose1, Mohammad R Amin2, Mohammad A Haq3, Atiqul Islam4, Fazle R Chowdhury5, Titu Miah2, Ulrich Kuch6, Mohammad A Faiz7, David Warrell8
1Department of Medicine, Chittagong Medical College, Bangladesh
2Department of Medicine, Dhaka Medical College, Bangladesh
3Department of Medicine, Rajshahi Medical College, Bangladesh
4Potuakhali Sadar Hospital, Potuakhali, Bangladesh
5Department of Medicine, Sylhet MAG Osmani Medical College, Bangladesh
6Department of Tropical Medicine and Public Health, Goethe University Frankfurt am Main, Germany
7Dev Care Foundation, Bangladesh
8Nuffield Department of Medicine, University of Oxford, Wellington Square, Oxford OX1 1AA, UK
Crusade against Snake Bite poisoning
Dileep P Punde1 and Gaurav D Punde2
1Senior Consultant Physician and Head, Punde Hospital Mukhed, Nanded, Maharashtra, India
2Senior Resident Mahatma Gandhi Mission Medical College, Aurangabad, Maharashtra, India
Snake Bite management experience in western Mah (INDIA)
Sadanand Raut and Pallavi Raut
Vighnahar Nursing Home Narayangaon Tal Junnar pune Mah, India
