Speakers & agenda
(subject to change)
Monday 10th April 2017 | Vernon Harcourt Room, The South Building | St Hilda’s College
0830: Registration, welcome coffee and networking
0900: Welcome and housekeeping
SESSION 1: Chemical design and modification – Chair Dr Mark Edbrooke, AstraZeneca, UK
0915: Professor Jesper Wengel
Center Director, BioNEC – A VKR Center of Excellence FKF – University of Southern Denmark, Denmark
Title: Lipo-LNA: Lipophilic 2’-amino-LNA derivatives for design of antisense oligonucleotides
0945: Professor Tom Brown
Professor of Nucleic Acid Chemistry, Department of Chemistry, University of Oxford, United Kingdom
Title: Chemical ligation of DNA, biocompatibility and applications of artificial backbones
1015: Dr Marcel Hollenstein
Group Leader, Institut Pasteur, Laboratory for Bioorganic Chemistry of Nucleic Acids, Department of Chemistry and Structural Biology, Paris, France
Title: Synthesis and biochemical characterization of modified nucleoside triphosphates for selection experiments
1045: Refreshment break, Exhibition, Posters (Dining Hall)
SESSION 2: Application – Chair Professor Dominic Wells, Royal Veterinary College, UK
1115: Professor Francesco Muntoni
Chair of Paediatric Neurology, UCL GOS Institute of Child Health, University College London, United Kingdom
Title: Antisense oligonucleotides to modify splicing in Duchenne muscular dystrophy and Spinal muscular atrophy
1145: Dr David Blakey
Chief Scientific Officer, MiNA Therapeutics, United Kingdom
Title: Mechanism and in vivo activity of a small activating RNA targeting CEBPA, a novel therapeutic in clinical trials for liver disease
1215: Professor Peter S Zammit
Randall Division of Cell and Molecular Biophysics, King’s College London, United Kingdom
Title: Ameliorating pathogenesis in Facioscapulohumeral muscular dystrophy by increasing SMCHD1 levels using saRNA
1245: Lunch (provided), Exhibition, Posters (Dining Hall)
SESSION 3: Delivery – Chair Professor Stefan Vogel, University of Southern Denmark, Denmark
1345: Dr Simon Richardson
Senior Lecturer, Biopharmaceutical Sciences, Faculty of Engineering & Science, University of Greenwich, London, United Kingdom
Title: A Further Evaluation of Attenuated Anthrax Toxin’s Application as an Antisense Delivery System
1415: Dr Manuela Aleku
Head of In-vivo Pharmacology – Drug Discovery, Silence Therapeutics GmbH, Berlin, Germany
Title: Therapeutic RNA delivery: into hepatocytes and beyond
1445: Professor Dominic J Wells
Department of Comparative Biomedical Sciences, Royal Veterinary College, United Kingdom
Title: Delivery of peptide conjugated PMO: effects of dose, age and steroids on muscle physiology in the mdx mouse
SESSION 4: Modelling, Labelling and Detection – Dr Daniel Schneider, SomaLogic, USA
1515: Dr Duncan Borthwick
Scientist, Dynamic Biosensors GmbH, Martinsried, Germany
Title: Modelling the Kinetics of Oligo Hybridisation and Ligase Activity Using A Regenerating Biochip, switchSENSE® Technology
1535: Refreshment break, Exhibition, Posters (Dining Hall)
1600: Dr Carlos Penedo
Principal Investigator, SUPA School of Physics and Astronomy, Biomedical Science Research Complex, University of St Andrews, United Kingdom
Title: Site-specific FRET-labelling of nascent RNA sequences within transcription complexes
1630: Dr Sylvain Ladame
Senior Lecturer and Deputy Director of Postgraduate Studies, Department of Bioengineering, Imperial College London, United Kingdom
Title: Subnanomolar Detection of Oligonucleotides via Templated Fluorogenic Reaction in Hydrogels: Controlling Diffusion to Improve Sensitivity
1700: Professor Andrew Miller
Professor of Biochemistry, King’s College London & Chief Scientific Officer at GlobalAcorn, London, United Kingdom
Title: Precision nanomedicines; the best of all possible worlds?
1730: Dr Julian A Tanner
Associate Professor and Coordinator of Education Division of Biochemistry, School of Biomedical Sciences at the University of Hong Kong, PR China
Title: Aptamers in DNA nanostructures as molecular sensing modules
1800: Discussion and close
