Conference Agenda & Distinguished Faculty
All presentations will be held in the Edward Boyle Auditorium, Jacqueline du Pré Music Building, St Hilda's College.
Day 1, 26th September
2.00-2.50pm: Registration and Coffee
2.50pm: Welcome and Housekeeping Announcements
Session 1: Chair Professor Christopher Reynolds
3.00pm: Dr Tom Davies
Associate Director of Structural Biology, Astex Pharmaceuticals, UK
Title: The use of fragment-based drug discovery to exploit alternative binding sites on proteins
3.30pm: Professor Mark Sansom - Keynote Address
Head of Biochemistry Department, University of Oxford, UK
Title: TBA
4.20pm: Refreshments, Networking and Posters
5.00pm: Dr Paul Finn
Chief Scientific Officer, Inhibox Ltd, UK
Title: Rapid and effective ligand-based virtual screening: Different tools for different jobs?
5.30pm: Dr Richard Law
Group Leader, Computational Chemistry, Evotec, UK
Title: Computational methods for fragment-based drug design
6.00pm: Dr Phil Biggin
Lecturer and Co-Director - Structural Bioinformatics and Computational Biochemistry Unit, University of Oxford, UK
Title: Insights into the mechanism of P-Glycoprotein from Molecular Dynamics Simulations
6.30pm: Close of Day 1
Day 2, 27th September
8.00-8.30am: Registration and Coffee
8.30am: Welcome and Housekeeping
Session 2: Chair Professor Robin Leatherbarrow
8.40am: Professor Isabel Bermudez-Diaz
Professor of Neuropharmacology, Oxford Brookes University, UK
Title: Non-orthosteric subunit interfaces and their role in alpha4beta2 nicotinic acetylcholine receptor properties
9.10am: Professor Klaus Müller - Keynote Address
Consultant, F Hoffmann-La Roche AG, Switzerland
Title: Polar lipocompatible units for property modulation in drug discovery
10.00am: Professor Barry Potter
Professor of Medicinal Chemistry, University of Bath, UK
Title: Approaches to drugging nucleotide Ca2+ - mobilizing second messengers
10.30am: Refreshments, Networking and Posters
11.10am: Dr Steven Thompson and Dr Manita Feenstra
Sigma Life Sciences, UK
Title: Bioactive Small Molecule Libraries in Screening and Generation of Downstream Platforms using Zinc Finger Nuclease Technology
11.30am: Dr Ijen Chen
Principal Scientist, Vernalis, UK
Title: Experiences in tackling protein-protein interaction targets for novel anti-cancer treatments
12.00pm: Professor Dr Dennis Servent
Institute of Biology and Technologies (iBiTEC-S), France
Title: Pharmacological, structural characterization and engineering of toxins interacting with GPCRs
12.30pm: Lunch
Session 3: Chair Professor Klaus Müller
3.00pm: Professor Christopher Reylonds - Keynote Address
Professor in Computational Chemistry, University of Essex, UK
Title: Computational approaches to GPCR structure
3.50pm: Professor Dr M Natalia DS Cordeiro
University of Porto, Portugal
Title: In silico multi-criteria virtual screening towards prioritising antibacterial peptidomimetics
4.20pm: Refreshments, Networking and Posters
5.00pm: Professor Robin Leatherbarrow
Imperial College London, UK
Title: Inhibitors of N-myristoyl transferases from Leishmania and Plasmodium as anti-parasite agents
5.30pm: Professor Ian Gilbert
University of Dundee, UK
Title: Drug discovery for neglected tropical diseases
6.00pm: Dr Pedro Ballester
Senior Researcher, EMBL-EBI, Wellcome Trust Genome Campus, Cambridge, UK
Title: Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit lead identification
6.30pm: Close of Day 2
7.15pm: Conference Dinner (By invitation or prior booking only)
Day 3, 28th September
Session 4: Chair Dr Phil Biggin
8.30am: Dr Giani
De Fabritiis
Acellera Ltd, Spain
Title: Fragment-based drug design using molecular dynamics
9.00am: Dr Luca Mannocci
Head of DNA-encoded Chemical Library and Drug Discovery Technologies,
Philochem AG, Switzerland
Title: DNA-encoded chemical libraries
9.30am: Dr Michael Bodkin
Research Advisor & CDD Group Leader, Medicinal Chemistry, Lilly, UK
Title: Targeting the Amyloid and Tau hypotheses by molecular design
10.00am: Refreshments and Networking
10.30am: Dr Zara Sands
Senior Scientists, UCB Pharma SA, Belgium
Title: Does molecular modeling have a place for driving drug design within a pharmaceutical setting?
11.00am: Dr Paul Bamborough
Principal Scientist, Galaxo-Smith-Kline, UK
Title: Playing the system: focused fragments for kinases and bromodomains
11.30am: Professor Dr Rob Leurs
Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, The Netherlands
Title: Fragment-based approaches towards GPCRs ligands
12.00pm: Dr Pratul Agarwal
CEO, Annavitas Biosciences, Knoxville, TN, and Computational Biology Institute, Oak Ridge National Laboratory, TN, USA
Title: Discovering and characterizing allosteric sites for novel drug design
12.20pm: Close of Academic Programme
12.30pm-1.00pm: Lunch and Close of Conference
